Effects of phenylpropanolamine on regulatory and nonregulatory ingestion in adult rats

Protracted ‘Pro-Addictive’ Phenotype Produced in Mice by Pre-Adolescent Phenylpropanolamine

“…As spontaneous locomotion, as well as drug-induced changes in motor hyperactivity, can depend upon the age of animal (eg, Bolanos et al, 1998;Carlezon and Konradi, 2004;Dafny and Yang, 2006;Niculescu et al, 2005;Spear and Brake, 1983), we examined for changes in the locomotor activity of juvenile mice in response to repeated PPA administration. Consistent with earlier reports for the locomotor effects of PPA in adult rats (Eisenberg et al, 1987;Mittleman et al, 1993), PPA administration to juvenile mice did not elicit motor hyperactivity, but rather suppressed locomotion in a doseindependent manner, relative to saline controls (Figure 1b). The earlier report by Mittleman et al (1993) implicated the locomotor-suppressive effects of even low doses of PPA (ie, 5 mg/kg) in the anorectic properties of this drug.…”

“…injection was estimated to be approximately 1.5-2 h (Figure 1a). Although sympathomimetic drugs can exert psychomotor-activating effects (eg, Eisenberg et al, 1987;Miller et al, 1999;Mittleman et al, 1993), earlier reports for PPA conducted in adult rats failed to observe hyperactivity in response to systemic injections of PPA (Eisenberg et al, 1987;Mittleman et al, 1993). As spontaneous locomotion, as well as drug-induced changes in motor hyperactivity, can depend upon the age of animal (eg, Bolanos et al, 1998;Carlezon and Konradi, 2004;Dafny and Yang, 2006;Niculescu et al, 2005;Spear and Brake, 1983), we examined for changes in the locomotor activity of juvenile mice in response to repeated PPA administration.…”

“…These doses of PPA are in the range of those used previously to examine the behavioral or neurochemical effects of PPA in adult rodents (Eisenberg et al, 1987;Mariathasan and Stolerman, 1992;Mittleman et al, 1993;Rushing et al, 1993;McMahon and Wellman, 1996). As PPA is an anorectic (eg, Eisenberg et al, 1987;Mittleman et al, 1993;Wellman, 1990), body weight was recorded daily before each injection. All injections, behavioral and neurochemical testing occurred during the light phase of the circadian cycle, between 0900 and 1600 h. Statistical analysis of the behavioral and neurochemical data revealed no main effects of, or interactions with, the sex factor.…”

“…PPA is an anorectic (Eisenberg et al, 1987;Mittleman et al, 1993;Wellman, 1990). Thus, we analyzed for the effects of PPA on weight gain in male and female pups during repeated treatment.…”

“…Despite its prevalence and sympathomimetic profile, the biopsychological effects of PPA have received very little experimental attention. Whereas PPA does not elicit locomotor hyperactivity in rats or maintain self-administration behavior in monkeys trained to selfadministered cocaine (Eisenberg et al, 1987;Mittleman et al, 1993;Woolverton et al, 1986), it substitutes for amphetamine in rat self-administration studies (Wellman et al, 1989). Moreover, PPA substitutes for illicit psychomotor stimulants in drug discrimination studies employing both human and nonhuman primates, as well as rodents (Chait et al, 1988;Lee et al, 1989;Mariathasan and Stolerman, 1992;Woolverton et al, 1986).…”