2023
DOI: 10.1111/jvim.16914
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Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses

Julianne M. White,
Aimee C. Colbath,
Harold C. Schott

Abstract: BackgroundTreatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX‐2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are unknown.HypothesisFurosemide‐induced diuresis after pretreatment with firocoxib or dipyrone is diminished to a lesser extent than after pretreatment with phenylbutazone.AnimalsEight healthy mares.MethodsEach mare received 4 treatments in a prospective experimental crossover stud… Show more

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