Effects of phenol peeling on dermal endothelial cells

Yamamoto, Yuki; Yonei, Nozomi; Kaminaka, Chikako; Kishioka, Akiko; Uede, Koji; Furukawa, Fukumi

doi:10.1016/j.jdermsci.2004.03.007

Cited by 14 publications

(15 citation statements)

References 8 publications

(6 reference statements)

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“…[56] Burning sensation for approximately 60 s, followed by a transient period and pain returning after 10 min, with a lesser intensity that lasts from minutes to hours, is known. Post-operative care should include delicate cleaning of the gingiva with saline and prescribed antibiotic regimen.…”

Section: Discussionmentioning

confidence: 99%

Split mouth de-epithelization techniques for gingival depigmentation: A case series and review of literature

Kathariya

Pradeep

2011

J Indian Soc Periodontol

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Gingival melanin pigmentation occurs in all races of mankind. Although clinical melanin pigmentation does neither present itself as a medical problem nor a disease entity, it is a major esthetic concern for many people, especially Asians. Esthetic gingival depigmentation procedures can be performed in such patients with excellent results. This case series presents a split mouth de-epithelization procedure using popular surgical techniques such as scalpel, bur abrasion or electrosurgery. These techniques were successfully used to treat gingival hyperpigmentation. Although we found that electrosurgery increased the efficacy of our work, giving a cleaner and neater work field, it required a lot of precision. In contrast, scalpel de-epithelization was easy and technique-friendly, giving excellent results and patient satisfaction. However, the cases are being followed-up to study the factors affecting the rate and length of time required for repigmentation and to study the repigmentation patterns. This case series also reviews the advantages and disadvantages of various techniques available for depigmentation, and reiterates that the scalpel technique still serves as a gold standard for depigmentation.

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Section: Discussionmentioning

confidence: 99%

Split mouth de-epithelization techniques for gingival depigmentation: A case series and review of literature

Kathariya

Pradeep

2011

J Indian Soc Periodontol

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“…The depth of penetration depends on the strength and/or amount of phenol applied, the tumor thickness, and tumor location. Our previous studies have indicated that phenol penetrates into the skin quickly and induces histologic changes in endothelial cells via apoptosis 7,8 . It is probable that apoptosis of endothelial cells in the dermis induces ischemic changes, eventually resulting in epidermal necrosis 7,8 .…”

Section: Discussionmentioning

confidence: 99%

“…Our previous results have suggested that phenol quickly penetrates the skin and induces endothelial cell damage more rapidly than keratinocyte damage 5,6 . It is probable that apoptosis of the endothelial cells in the dermis induces ischemic changes and necrotic changes throughout the epidermis 7,8 . Cutaneous angiosarcoma (AS) is a rare, aggressive endothelial sarcoma that arises most commonly on the head and neck of elderly people 9 .…”

Section: Introductionmentioning

confidence: 99%

“…5,6 It is probable that apoptosis of the endothelial cells in the dermis induces ischemic changes and necrotic changes throughout the epidermis. 7,8 Cutaneous angiosarcoma (AS) is a rare, aggressive endothelial sarcoma that arises most commonly on the head and neck of elderly people. 9 Based on the finding that the origin of AS is an endothelial cell, it is conceivable that the antiangiogenic activity of phenol is the mechanism con-tributing to the therapeutic efficacy against AS; however, few clinical studies have suggested the involvement of apoptosis in tumor cell death after phenol application.…”

Section: Introductionmentioning

confidence: 99%

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Phenol application to angiosarcomas: implications and histologic studies

et al. 2009

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“…7,8 It is likely that the apoptosis of endothelial cells in the dermis induce ischemic changes, eventually resulting in epidermal necrosis. 9,10 When absorbed systemically, phenol may cause serious side effects such as cardiac toxicity, liver and kidney damage, and respiratory depression. 11 These side effects highly correlate with the duration of the procedure and peeled surface area.…”

mentioning

confidence: 99%