Effects of phencyclidine on auditory gating in the rat hippocampus and the medial prefrontal cortex

Dissanayake, Dilshani W. N.; Zachariou, Margarita; Marsden, C.A.; Mason, Robert J.

doi:10.1016/j.brainres.2009.08.032

Cited by 14 publications

(10 citation statements)

References 55 publications

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“…Power density values were calculated by fast Fourier transformation (FFT) of artefact-free epochs under condition of 0.61 Hz resolution with a Hanning window for 5 min peri-ods before the auditory stimuli in the frequency range of delta (0.6-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and gamma1 (30-48 Hz), gamma2 (52-70 Hz) and gamma3 (71-100 Hz) bins/waves. Relative band powers were expressed as power ratios of each frequency band to the total (z-score).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, developing animal models with abnormal EEG activity may help in the clarification of the mechanisms in the background of this neuropsychiatric disease [10,11]. Previous studies using different rodent models of schizophrenia showed widely diversified alterations in the power of EEG oscillations and event related potentials (ERP) [12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological alterations in a complex rat model of schizophrenia

Horváth

Petrovszki

Kekesi

et al. 2016

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrophysiological alterations in a complex rat model of schizophrenia

Horváth

Petrovszki

Kekesi

et al. 2016

Behavioural Brain Research

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“…Likewise, the dopamine receptor agonist apomorphine dose-dependently reduced the amplitude response to S1 stimuli and thereby increased the S2/S1 ratio as well as the gating deficit in rats [110]. The antipsychotic clozapine prevented the auditory gating deficits induced by PCP in the CA3, dentate gyrus, and medial prefrontal cortex [111]. …”

Section: Pharmaco-event-related Potentialsmentioning

confidence: 99%

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Drinkenburg

Ruigt²,

Ahnaou

2015

Neuropsychobiology

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The contemporary value of animal pharmaco-electroencephalography (p-EEG)-based applications are strongly interlinked with progress in recording and neuroscience analysis methodology. While p-EEG in humans and animals has been shown to be closely related in terms of underlying neuronal substrates, both translational and back-translational approaches are being used to address extrapolation issues and optimize the translational validity of preclinical animal p-EEG paradigms and data. Present applications build further on animal p-EEG and pharmaco-sleep EEG findings, but also on stimulation protocols, more specifically pharmaco-event-related potentials. Pharmaceutical research into novel treatments for neurological and psychiatric diseases has employed an increasing number of pharmacological as well as transgenic models to assess the potential therapeutic involvement of different neurochemical systems and novel drug targets as well as underlying neuronal connectivity and synaptic function. Consequently, p-EEG studies, now also readily applied in modeled animals, continue to have an important role in drug discovery and development, with progressively more emphasis on its potential as a central readout for target engagement and as a (translational) functional marker of neuronal circuit processes underlying normal and pathological brain functioning. In a similar vein as was done for human p-EEG studies, the contribution of animal p-EEG studies can further benefit by adherence to guidelines for methodological standardization, which are presently under construction by the International Pharmaco-EEG Society (IPEG).

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“…EEG abnormalities are well characterized in schizophrenia (Cho et al, 2006;Hong et al, 2012;Rutter et al, 2009;Uhlhaas and Singer, 2010), bipolar disorder (Clementz et al, 1994), alcohol dependence (Costa and Bauer, 1997), and other psychiatric conditions. Previous studies have assessed EEG and evoked potentials in rodent models (Bickel et al, 2008;Broberg et al, 2010;Dissanayake et al, 2009;Ehrlichman et al, 2009b;Hakami et al, 2009;Vohs et al, 2009), and recent evidence suggests surface EEG is correlated with neural synchrony among local field potential (LFP) sites (Musall et al, 2014). However, the results are difficult to compare with human data due to very different approaches in how the signals are acquired and processed.…”

Section: Introductionmentioning

confidence: 99%

Reverse Translation of Clinical Electrophysiological Biomarkers in Behaving Rodents under Acute and Chronic NMDA Receptor Antagonism

Sullivan

Timi

Hong

et al. 2014

Neuropsychopharmacol

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Electroencephalogram (EEG) stands out as a highly translational tool for psychiatric research, yet rodent and human EEG are not typically obtained in the same way. In this study we developed a tool to record skull EEG in awake-behaving rats in a similar manner to how human EEG are obtained and then used this technique to test whether acute NMDA receptor antagonism alters rodent EEG signals in a similar manner as in humans. Acute MK-801 treatment elevated gamma power and reduced beta band power, which closely mirrored EEG data from healthy volunteers receiving acute ketamine. To explore the mechanisms behind these oscillatory changes, we examined the effects of GABA-A receptor blockade, finding that picrotoxin (PTX) recapitulated the decrease in sound-evoked beta oscillations observed with acute MK-801, but did not produce changes in gamma band power. Chronic treatment with either PTX or MK-801 did not affect frequency-specific oscillatory activity when tested 24 h after the last drug injection, but decreased total broadband oscillatory power. Overall, this study validated a novel platform for recording rodent EEG and demonstrated similar oscillatory changes after acute NMDA receptor antagonism in both humans and rodents, suggesting that skull EEG may be a powerful tool for further translational studies.

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Effects of phencyclidine on auditory gating in the rat hippocampus and the medial prefrontal cortex

Cited by 14 publications

References 55 publications

Electrophysiological alterations in a complex rat model of schizophrenia

Electrophysiological alterations in a complex rat model of schizophrenia

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Reverse Translation of Clinical Electrophysiological Biomarkers in Behaving Rodents under Acute and Chronic NMDA Receptor Antagonism

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