Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats

Wu, Cuishuan; Wang, Xueqing; Meng, Meng; Li, Ming-Guang; Zhang, Hua; Zhang, Xuan; Wang, Jiancheng; Wu, Tianxiao; Nie, Wen-hui; Zhang, Qiang

doi:10.3109/02652040903059163

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…It was observed that the nanoparticles decreased the distribution and adhesion of Rho in the stomach but increased these values in the intestine. Additionally, these nanocarriers were reported to control the drug release sites and release rate in the GI tract [103]. Scientists have also investigated the potential of ES 100 to improve oral delivery of HIV-1 protease inhibitors in dogs [104].…”

Section: Published By Woodhead Publishing Limited 2012mentioning

confidence: 99%

Nanoparticulate systems as drug carriers: the need

Patravale¹,

Dandekar²,

Jain³

2012

Nanoparticulate Drug Delivery

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Section: Published By Woodhead Publishing Limited 2012mentioning

confidence: 99%

Nanoparticulate systems as drug carriers: the need

Patravale¹,

Dandekar²,

Jain³

2012

Nanoparticulate Drug Delivery

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“…The choice of a hydrophilic brush surface is motivated by the common use of brushes to prevent fouling on biomedical devices, on membranes, and within diagnostic systems. , Hydrogen bonding to brushy surfaces may, however, control particle capture and delivery in the gut, − and at the level of single cells, hydrogen bonds may contribute to selectin-mediated neutrophil rolling. − Particles coated with engineered brushes also comprise important delivery vehicles. , …”

Section: Introductionmentioning

confidence: 99%

Near-Surface Motion and Dynamic Adhesion during Silica Microparticle Capture on a Polymer (Solvated PEG) Brush via Hydrogen Bonding

Kalasin

Santore

2015

Macromolecules

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Surface modification by “polymer brushes” (dense end-tethered chains) is a strategy to create a steric barrier against colloidal aggregation or bioadhesion or to facilitate lubrication. The approach requires good brush solvation; however, even in a good solvent, brush chains can adhere certain objects. An important example is the hydrogen bonding of silica to PEG (poly(ethylene glycol)) chains in water. To probe how hydrogen bonding at the brush periphery facilitates adhesive capture of flowing particles, we employ a model system comprising silica microspheres on biorepellant PEG brushes sufficiently thick to screen interactions with the underlying substrate. We find that capture of silica spheres on PEG brushes is slower and less efficient than the transport-limited rate and can be hindered by the addition of salt and by flow, up to wall shears at least 500 s–1. Individual flowing silica microparticles adhere gradually to the PEG brush (presumably by increasing the numbers of H-bonds), so that the particle motion slows prior to arrest. The deceleration length is on the order of tens of microns and is salt- and shear-dependent. By contrast, capture of the same particles on electrostatically attractive surfaces is transport-limited and occurs when particles “jump” tens of nanometers to the surface within a fraction of a second rather than translating near the surface. These distinctly different near-surface motion signatures may result from fundamental differences in interactions: PEG–silica hydrogen bonding is short-range and requires registry of interacting groups, while electrostatic attractions are long-range. These differences in interactions likely translate to a slower forward binding constant for hydrogen bonding compared with the diffusion-limited rate of particle capture in an electrostatically attractive well. The adhesion of silica particles to a PEG brush comprises a model for other particles containing H-bond donor surface functionality (silanols, alcohols, amines) and provides a powerful example of lubrication versus adhesion at a surface presenting nanoscale deformability.

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