Effects of pH and surface pressure on morphology of glycine crystals formed beneath the phospholipid Langmuir monolayers

Ye, Mu; Xiao, Fei; Zhang, Ren‐Jie; Li, Hongying; Huang, Wei; Feng, Xi; Liu, Hong-Guo

doi:10.1016/j.jcrysgro.2005.08.010

Cited by 8 publications

(1 citation statement)

References 30 publications

(53 reference statements)

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“…As such, the model may be applied to investigate the chemical complementarity between APIs/biologically relevant molecules at the alveolar air‐liquid interface. Indeed, the potential of Langmuir monolayers to stimulate crystal formation was successfully demonstrated by Mu and co‐workers during 2005, whereby the group employed DPPC monolayers to induce and control glycine crystal development . Various operating parameters were noted to influence resultant crystal habits; including for instance the pH of the subphase and monolayer surface pressure.…”

Section: Introductionmentioning

confidence: 99%

Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung‐specific additives

Davies

Taylor

Leach

et al. 2017

Surface & Interface Analysis

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8Pain is a prevalent condition that can have a serious impact upon the socioeconomic function of a population. 9Numerous methods exist to administer analgesic medication (e.g. aspirin) to the body however inherent 10 drawbacks limit patient acceptability. The inhaled route offers promise to facilitate the administration of 11 medication to the body. Here, we consider the crystallisation behaviour of aspirin, our model therapeutic 12 agent, when in contact with material of relevance to the lung. Thus, our approach aims to better understand 13 the interaction between drug substances and the respiratory tract. Langmuir monolayers composed of a 14 mixed surfactant system were supported on an aqueous subphase containing aspirin (7.5mg/ml). The 27Inhaled drug delivery, Langmuir monolayers, aspirin, antisolvent crystallisation, X-ray diffraction (XRD) and 28 scanning electron microscopy (SEM).

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Section: Introductionmentioning

confidence: 99%

Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung‐specific additives

Davies

Taylor

Leach

et al. 2017

Surface & Interface Analysis

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Crystallization of β‐glycine by spray drying

Sander

Penović

Šipušić

2011

Cryst. Res. Technol.

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Glycine crystallization during spray drying has been investigated on a laboratory scale. In order to obtain different polymorphs the experiments have been performed at different hot air temperatures, concentrations, different flow of the solution and spraying air. The obtained crystals were analyzed by means of X-ray powder diffractometry, differential scanning calorimetry and the Fourier transform infrared spectrometry. Crystallization mostly resulted with a mixture of α-and β-glycine with a small amount of γ-glycine. The glycine polymorphism is affected by the drying air temperature, concentration and the flow of the solution, as well as the spraying air flow. Decrease of the drying air temperature and increase of the solution flow rate causes the increase of the quantity of β-glycine. At room conditions, β-glycine spontaneously transforms into thermodynamically more stable α-glycine.

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Structural, dielectric, thermal and antibacterial properties of a ferroelectric single crystal: bis-glycine cobalt sulphate pentahydrate

Balakrishnan

Revathi

Krishnaveni

et al. 2018

J Mater Sci: Mater Electron

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Effects of pH and surface pressure on morphology of glycine crystals formed beneath the phospholipid Langmuir monolayers

Cited by 8 publications

References 30 publications

Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung‐specific additives

Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung‐specific additives

Crystallization of β‐glycine by spray drying

Structural, dielectric, thermal and antibacterial properties of a ferroelectric single crystal: bis-glycine cobalt sulphate pentahydrate

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