Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity

Pinello, Kátia Cristina; Fonseca, Evelise de Souza Monteiro; Akisue, Gokithi; Silva, Ana Paula; Oloris, Sı́lvia Catarina Salgado; Sakai, Mônica; Matsuzaki, Patrı́cia; Nagamine, Márcia Kazumi; Neto, José Pereira de Queiroz; Dagli, M.L.

doi:10.1016/j.lfs.2005.06.040

Cited by 24 publications

(15 citation statements)

References 37 publications

(32 reference statements)

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“…The development of the ascitic form of the Ehrlich tumor is tightly linked to the activity of the immune system (19) and particularly to the activation of resident macrophages (31). Indeed, macrophages are the prevalent mononuclear cell population that migrates to Ehrlich tumor focus where they operate at the tumor-host interface and modulate Ehrlich tumor growth (32).…”

Section: Discussionmentioning

confidence: 99%

Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice

Quinteiro-Filho

Righi

Palermo-Neto

2009

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice

Quinteiro-Filho

Righi

Palermo-Neto

2009

Braz J Med Biol Res

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“…They are bigger and display pronounced ruffling of the plasma membrane, and increased capacity for adherence and spreading on surfaces, increased formation of pseudopods, and increased number of picnotic vesicles, as well as functional differences. 31 The results obtained for spreading macrophages have shown that complex (1) presents an expressive value of 62.0% ± 22.81, different from that found in the tumour control group and similar to cis-DDP value of 78.4 % ± 16.82 (p<0.001), while complex (2) did not present the same effect: 37.4% ± 11.78.…”

Section: Biological Activitiesmentioning

confidence: 70%

Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

Rocha¹,

Santana²,

Ananias³

et al. 2007

J. Braz. Chem. Soc.

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Os ciclometalados de paládio(II) são compostos inorgânicos reativos empregados em vários estudos biológicos devido a seu potencial antitumoral e interação com o sistema imune. Neste estudo, a resposta imune e citotóxica induzida por dois complexos organopaladados: [{Pd(N,C-dmba)} 2 (μ-NCS) 2 ] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N'-dimetilbenzilamina, dppp = 1,3-bis(difenilfosfino)propano] e cisplatina (cis-DDP), como padrão, foram investigados em camundongos portadores do tumor ascítico de Ehrlich. Os camundongos foram divididos em cinco grupos e inoculados com (1) ou (2) ou cis-DDP ou apenas veículo ou solução salina tamponada de fosfatos (PBS). Diversos parâmetros foram avaliados, tais como a porcentagem de células tumorais presentes no exsudato peritoneal, os níveis de óxido nítrico (NO) e fator de necrose tumoral (TNF-α) séricos e o aumento na expectativa de vida. Os dados obtidos demonstram que o composto (2) apresentou atividade similar à da cis-DDP, como, por exemplo, aumento na expectativa de vida, diminuição dos níveis séricos de TNF-α e aumento da produção de NO.Cyclometallated palladium(II) complexes are reactive inorganic compounds employed in several biological studies because of their antitumour potential and interaction with immune system. In the present study, the immune and citotoxic response induced by two organopalladated complexes: [{Pd(N,C-dmba)} 2 (μ-NCS) 2 ] (1), [Pd(C-dmba)(NCS)(dppp)] (2) [dmba = N,N'-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphino)propane] and cisplatin (cis-DDP), as standard, were investigated in mice bearing Ehrlich ascites tumour. The mice were divided into five groups and inoculated with the compounds (1) or (2) or cisplatin, or only vehicle or phosphatebuffered saline (PBS). Many parameters were evaluated, such as tumour cell percentage in the peritoneal exsudate, levels of seric nitric oxide (NO) and tumour necrosis factor-alpha (TNF-α) and increase in life span. Analysis of all data revealed, for compound (2), an activity similar to that presented by cisplatin, resulting in increased life span, lower levels of seric TNF-α and increase in NO production.Keywords: palladium(II) complexes, Ehrlich ascites tumour, macrophages, nitric oxide, tumour necrosis factor-alpha. IntroductionCancer is a disease in which unremitting clonal expansion of somatic cells kills by invading, subverting, and eroding normal tissues. 1 Millions of people die every year from the metastatic spread of cancer that occurs through blood and lymphatic vessels or directly into tissues and body cavities. 2 Between the several types of cancer, breast cancer is the most common malignancy in women worldwide. 3 In some cases, immune cells constitute a prominent component of the host response to cancer, but their participation in tumour pathogenesis remains not completely understood. Dense intratumoral lymphocyte cis-Diamminedichloroplatinum(II), 9 a clinically important antitumour drug, acts like a classical alkylating agent in chemotherapy against some types of cancers. It is a potent ...

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“…A literatura científica não apresenta nenhum relato sobre a atividade hipocolesterolêmica desta espécie, sendo que as atividades farmacológicas deste gênero versam basicamente sobre a droga na forma de pó da raiz, com extrato bruto ou semi-purificado (Vigo et al, 2004). Um dos principais efeitos da P. paniculata se deve a atividade antitumoral do ácido fáfico e fafosídeos (Nishimoto, 1984;Pinello et al, 2006).…”

Section: Echinodorus Grandiflorus Bauhinia Forficata Tabebuia Avellunclassified

Plantas com possível atividade hipolipidêmica: uma revisão bibliográfica de livros editados no Brasil entre 1998 e 2008

Pizziolo

Brasileiro

Oliveira

et al. 2011

Rev. bras. plantas med.

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RESUMO:O objetivo deste trabalho foi realizar levantamento sobre as plantas medicinais indicadas para o tratamento da hiperlipidemia, hipercolesterolemia e/ou aterosclerose. Este estudo foi feito a partir da pesquisa bibliográfica em 32 livros publicados no Brasil entre 1998 e 2008, resultando em lista de 85 espécies distribuídas em 53 famílias, principalmente Asteraceae e Fabaceae, com 54 espécies exóticas e 31 nativas. As espécies mais citadas foram Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) e Curcuma zedoaria (Zingiberaceae). As espécies nativas, citadas em pelo menos 2 livros, foram investigadas para alguma evidencia científica relacionada a possíveis efeitos hipolipidêmico, hipocolesterolêmico e/ou contra aterosclerose. Somente foram encontrados estudos científicos, relacionados a estes efeitos, para as espécies nativas Cuphea carthagenensis e Echinodorus grandiflorum, indicando a necessidade de pesquisas que possam garantir a segurança e a eficácia do uso destas espécies.Palavras-chave: aterosclerose, hipercolesterolemia, hiperlipidemia, plantas medicinais ABSTRACT: Plants with possible hypolipidemic activity: a review of books published in Brazil between 1998 and 2008. The aim of this study was to survey medicinal plants indicated for the treatment of hyperlipidemia, hypercholesterolemia and/or atherosclerosis. This study was performed from a review of 32 books published in Brazil between 1998 and 2008, resulting in a list of 85 species belonging to 53 families, especially Asteraceae and Fabaceae, with 54 exotic and 31 native species. The species most often cited were Allium sativum (Alliaceae), Cynara scolymus (Asteraceae), Curcuma longa (Zingiberaceae), Allium cepa (Alliaceae), Echinodorus grandiflorus (Alismataceae), Taraxacum officinale (Asteraceae), Vernonia condensata (Asteraceae), Cuphea carthagenensis (Lythraceae) and Curcuma zedoaria (Zingiberaceae). Native species cited in at least 2 books were investigated for some scientific evidence related to possible hypolipidemic and hypocholesterolemic effects and/or action against atherosclerosis. Scientific studies related to these effects were found only for the native species Cuphea carthagenensis and Echinodorus grandiflorum, indicating the need for studies capable of assuring the safety and the efficacy as to the use of these species.Key words: atherosclerosis, hypercholesterolemia, hyperlipidemia, medicinal plants INTRODUÇÃOOs últimos 30 anos tem presenciado um declínio razoável da mortalidade por causas cardiovasculares em países desenvolvidos, enquanto que elevações rápidas e substanciais tem ocorrido em países em desenvolvimento, dentre eles o Brasil. De acordo com a OMS, esta tendência de aumento na doença cardiovascular tende a persistir, agravando ainda mais o quadro de morbidade e mortalidade elevadas nos países em desenvolviment...

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Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity

Cited by 24 publications

References 37 publications

Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice

Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice

Citotoxicity and immune response induced by organopalladium(II) compounds in mice bearing Ehrlich ascites tumour

Plantas com possível atividade hipolipidêmica: uma revisão bibliográfica de livros editados no Brasil entre 1998 e 2008

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