Effects of petrochemical contamination on caged marine mussels using a multi-biomarker approach: Histological changes, neurotoxicity and hypoxic stress

Maisano, Maria; Cappello, Tiziana; Natalotto, Antonino; Vitale, Valeria; Parrino, Vincenzo; Giannetto, Alessia; Oliva, Sabrina; Mancini, Giuseppe; Cappello, Simone; Mauceri, Angela; Fasulo, Salvatore

doi:10.1016/j.marenvres.2016.03.008

Cited by 107 publications

(51 citation statements)

References 33 publications

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“…Nadir et al [21] reported that Mercury contamination has a direct influence on biomarkers in Donax trunculus. Other types of pollution can affect AChE activity, like wastewater [22], contamination by polycyclic aromatic hydrocarbons (PAHs), and organic chemicals [14,[40][41][42]. Our results corroborate those of Lagbouri [43] and Moukrim et al [16] in Anza beach (Agadir Bay) using the other sentinel species Donax trunculus.…”

Section: Discussionsupporting

confidence: 86%

A Multibiomarker Approach to Assess the Health State of Coastal Ecosystem Receiving Desalination Plants in Agadir Bay, Morocco

Elazzaoui

Moukrim

Lefrere

2019

The Scientific World Journal

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The present study aims to evaluate the initial health status of two stations receiving seawater desalination plants in Agadir Bay (Tifnit-Douira and Cap Ghir) and to assess their potential environmental impact on the marine ecosystem health. Six pairs of mussels (Mytilus galloprovincialis) were collected at six sampling sites on a monthly basis over two years. Each pair was homogenized to obtain the postmitochondrial fractions (S9). Toxicological effects were measured using a multibiomarker approach based on either acetylcholinesterase (AChE), glutathione S-transferase (GST), catalase (CAT), and malondialdehyde (MDA) rate. The results show a seasonal variation of the biomarkers: their activities increase in summer and decrease in spring and winter. High activities were recorded during summer in Cap Ghir (17.94 ± 0.88; 5.91 ± 052 nmol/min/mg of protein) for CAT and MDA, respectively. In Tifnit-Douira, low activities were recorded during winter for GST (3.74 ± 0.52 nmol/min/mg of protein) and during spring for the CAT (3.52 ± 0.45 nmol/min/mg of protein). The fluctuations in the activities of measured biomarkers could be attributed to different factors including the changes in environmental parameters, the influence of seasonal variation, and the contamination of the aquatic ecosystem. The data obtained in this study should be taken into account in the monitoring and management of the health of the ecosystems when the desalination plants are established.

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Section: Discussionsupporting

confidence: 86%

A Multibiomarker Approach to Assess the Health State of Coastal Ecosystem Receiving Desalination Plants in Agadir Bay, Morocco

Elazzaoui

Moukrim

Lefrere

2019

The Scientific World Journal

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“…In what regards to mussels' neurotoxic status, the present study demonstrated that La strongly induced the inhibition of the AChE enzyme, evidencing a clear neurotoxicity capacity of this pollutant. AChE is an enzyme responsible for the breakdown of acetylcholine and has been widely used as an indicator of neurotoxicity in aquatic ecotoxicology due to its high sensitivity to many neurotoxic compounds such as metals (Maisano et al, 2017). Several studies already demonstrated the neurotoxic capacity of metals by inhibition of AChE in bivalves, including in mussels (Attig et al, 2010;Chalkiadaki et al, 2014) and in clams (Liu et al,2011;Matozzo et al, 2005).…”

Section: Neurotoxicitymentioning

confidence: 99%

Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts

et al. 2019

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Highlights  Mytilus galloprovincialis bioaccumulated lanthanum  Mussels exposed to Lanthanum decreased their metabolic capacity  Contaminated mussels activated their antioxidant and biotransformation defences  Contaminated mussels showed increased lipid peroxidation and lower GSH/GSSG ratio  Neurotoxicity was induced in contaminated mussels  Histopathological alterations were induced by lanthanum Summary Inappropriate processing and disposal of electronic waste contributes to the contamination of aquatic systems by various types of pollutants such as the rare-earth elements (REE) in which lanthanum (La) is included. Knowledge on the toxicity of these elements in marine organisms is still scarce when compared to other metals such as mercury (Hg) and arsenic (As).

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“…Regarding detoxification of organic contaminants, the activity of glutathione S-transferase (GST), involved in phase II (conjugation), is a widely used biomarker in organisms exposed to PAHs (e.g., Kopecka et al 2006;Richardson et al 2008;Turja et al 2014b). Exposure to oil compounds has shown to cause neurotoxic effects, e.g., inhibition of acetylcholinesterase (AChE) enzyme activity (Maisano et al 2017). Moreover, severe geno-and cytotoxic effects have been reported in response to oil contamination, including the formation of micronuclei (MN) and other nuclear deformities (Baršienė et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Biomarker responses and accumulation of polycyclic aromatic hydrocarbons in Mytilus trossulus and Gammarus oceanicus during exposure to crude oil

Turja

Sanni

Stankevičiūtė

et al. 2020

Environ Sci Pollut Res

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In the brackish water Baltic Sea, oil pollution is an ever-present and significant environmental threat mainly due to the continuously increasing volume of oil transport in the area. In this study, effects of exposure to crude oil on two common Baltic Sea species, the mussel Mytilus trossulus and the amphipod Gammarus oceanicus, were investigated. The species were exposed for various time periods (M. trossulus 4, 7, and 14 days, G. oceanicus 4 and 11 days) to three oil concentrations (0.003, 0.04, and 0.30 mg L −1 based on water measurements, nominally aimed at 0.015, 0.120, and 0.750 mg L −1 ) obtained by mechanical dispersion (oil droplets). Biological effects of oil exposure were examined using a battery of biomarkers consisting of enzymes of the antioxidant defense system (ADS), lipid peroxidation, phase II detoxification (glutathione S-transferase), neurotoxicity (acetylcholinesterase inhibition), and geno-and cytotoxicity (micronuclei and other nuclear deformities). In mussels, the results on biomarker responses were examined in connection with data on the tissue accumulation of polycyclic aromatic hydrocarbons (PAH). In M. trossulus, during the first 4 days of exposure the accumulation of all PAHs in the two highest exposure concentrations was high and was thereafter reduced significantly. Significant increase in ADS responses was observed in M. trossulus at 4 and 7 days of exposure. At day 14, significantly elevated levels of geno-and cytotoxicity were detected in mussels. In G. oceanicus, the ADS responses followed a similar pattern to those recorded in M. trossulus at day 4; however, in G. oceanicus, the elevated ADS response was still maintained at day 11. Conclusively, the results obtained show marked biomarker responses in both study species under conceivable, environmentally realistic oil-in-seawater concentrations during an oil spill, and in mussels, they are related to the observed tissue accumulation of oil-derived compounds.

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Effects of petrochemical contamination on caged marine mussels using a multi-biomarker approach: Histological changes, neurotoxicity and hypoxic stress

Cited by 107 publications

References 33 publications

A Multibiomarker Approach to Assess the Health State of Coastal Ecosystem Receiving Desalination Plants in Agadir Bay, Morocco

A Multibiomarker Approach to Assess the Health State of Coastal Ecosystem Receiving Desalination Plants in Agadir Bay, Morocco

Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts

Biomarker responses and accumulation of polycyclic aromatic hydrocarbons in Mytilus trossulus and Gammarus oceanicus during exposure to crude oil

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