Effects of pesticides on human physiology, genetics, and evolution

Karwal, Preeti; Mittal, Pooja; Nagar, Garima; Singh, Archana; Singh, Ishwar

doi:10.1016/b978-0-323-85160-2.00005-6

Cited by 3 publications

(1 citation statement)

References 93 publications

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“…Currently, the study of pollutants action on living organisms is the main goal of environmental monitoring, of which genetic monitoring is an integral part. Living organisms, including humans, are constantly exposed to a variety of environmentally hazardous factors of physical, chemical and biological nature, the vast majority of which, as has been shown in experimental studies, exhibit toxic, mutagenic and carcinogenic properties [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Study of the toxic and genotoxic activity of water of lake Kolsai, located on the territory of the Almaty region of the Republic of Kazakhstan

Zhadil

Lovinskaya

Kolumbayeva

et al. 2022

EJE

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An important step in assessing the state of natural environment is the identification of various environmentally hazardous factors that possess toxic, genotoxic and mutagenic activity. The appearance in the environment of a new pollutants and an increase in the concentration of already present physicochemical components that exhibit toxic and genotoxic properties contribute to environmental mutational load on biota. In recent decades, due to the intensification of economic activity and the development of the tourism sector, the anthropogenic load has significantly increased not only on terrestrial, in particular mountain ecosystems, but also on natural water reservoirs. In this regard, the purpose of this study was to investigate the genotoxic, mutagenic and toxic activity of surface water of the freshwater lake Nizhny Kolsai, located on the territory of national park "Kolsai kolderi" in the Kegen district of the Almaty region, Republic of Kazakhstan. For the first time, using a number of test systems (DNA comet method, cytogenetic test for accounting for chromosomal aberrations and biochemical analysis of lipid peroxidation products), water samples taken in 2018 and 2022 (spring-summer period) were studied at the Mus musculus model facility. It was found that water samples induced DNA breaks in cells of bone marrow and spleen of experimental mice, the level of which was significantly higher than in intact animals (p<0.001). Cytogenetic analysis of the bone marrow of mice treated with lake water also showed a statistically significant increase in the frequency of aberrant cells and the number of structural chromosome aberrations per 100 metaphases (p<0.05). A biochemical study of lipid peroxidation products (LPO) in the liver of experimental animals also revealed a statistically significant (p<0.05) increase in the level of lipid hydroperoxide (HPL) and malondialdehyde (MDA). The results obtained indicate the presence in the studied natural surface waters of chemicals with genotoxic, mutagenic and toxic activity.

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Section: Introductionmentioning

confidence: 99%

Study of the toxic and genotoxic activity of water of lake Kolsai, located on the territory of the Almaty region of the Republic of Kazakhstan

Zhadil

Lovinskaya

Kolumbayeva

et al. 2022

EJE

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Toxic effects of fenvalerate in tadpoles of Fejervarya limnocharis: a multiparametric study

Das,

Patar,

Singha

et al. 2024

Environ Sci Pollut Res

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Natural Plant Extracts: An Update about Novel Spraying as an Alternative of Chemical Pesticides to Extend the Postharvest Shelf Life of Fruits and Vegetables

et al. 2022

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Fresh fruits and vegetables, being the source of important vitamins, minerals, and other plant chemicals, are of boundless importance these days. Although in agriculture, the green revolution was a milestone, it was accompanied by the intensive utilization of chemical pesticides. However, chemical pesticides have hazardous effects on human health and the environment. Therefore, increasingly stimulating toward more eco-friendly and safer alternatives to prevent postharvest losses and lead to improving the shelf life of fresh fruits and vegetables. Proposed alternatives, natural plant extracts, are very promising due to their high efficacy. The plant-based extract is from a natural source and has no or few health concerns. Many researchers have elaborated on the harmful effects of synthetic chemicals on human life. People are now much more aware of safety and health concerns than ever before. In the present review, we discussed the latest research on natural alternatives for chemical synthetic pesticides. Considering that the use of plant-based extracts from aloe vera, lemongrass, or neem is non-chemical by-products of the fruits and vegetable industry, they are proved safe for human health and may be integrated with economic strategies. Such natural plant extracts can be a good alternative to chemical pesticides and preservatives.

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Effects of pesticides on human physiology, genetics, and evolution

Cited by 3 publications

References 93 publications

Study of the toxic and genotoxic activity of water of lake Kolsai, located on the territory of the Almaty region of the Republic of Kazakhstan

Study of the toxic and genotoxic activity of water of lake Kolsai, located on the territory of the Almaty region of the Republic of Kazakhstan

Toxic effects of fenvalerate in tadpoles of Fejervarya limnocharis: a multiparametric study

Natural Plant Extracts: An Update about Novel Spraying as an Alternative of Chemical Pesticides to Extend the Postharvest Shelf Life of Fruits and Vegetables

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