Effects of Persistent Atrial Fibrillation on Serum Galectin-3 Levels

Gürses, Kadri Murat; Yalçın, Muhammed Ulvi; Koçyiğit, Duygu; Canpınar, Hande; Evranos, Banu; Yorgun, Hikmet; Şahiner, Mehmet Levent; Kaya, Ergün Barış; Özer, Necla; Tokgözoğlu, Lâle; Oto, Mehmet Ali; Güç, Dicle; Aytemir, Kudret

doi:10.1016/j.amjcard.2014.12.021

Cited by 61 publications

(59 citation statements)

References 29 publications

(23 reference statements)

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“…Recent evidence has shown that galectin-3 is activated in fibrotic models and is abnormally increased in fibrotic diseases in general [37] and in the liver in particular [38, 39]. Concurrently, the evidence of the association between galectin-3 and cardiac fibrosis in the heart failure is convincing, [37] but the association of AF and galectin-3 is unclear: according to some reports, galectin-3 is just a bystander in the fibrinogenesis of the heart, with overall co-morbidity, particularly obesity, as the real promoter of fibrosis, whereas some reports point out that even ‘lone AF’, i.e., AF without co-morbidities, increases galectin-3 values [40–43]. Thereby, galectin-3 and NOX-4 may have a role in the fibrinogenesis of both the heart and liver.…”

Section: Discussionmentioning

confidence: 99%

Presence of atrial fibrillation is associated with liver stiffness in an elderly Finnish population

et al. 2017

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BackgroundChronic liver injury from different etiologies drives liver fibrosis. However, little is known about the associated factors, systemic factors in particular. Recently, non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation have been shown to be associated with each other. Thereby, we aimed to study the association between atrial fibrillation and liver stiffness.StudyExtensive clinical measurements including echocardiography of the heart, transient elastography (TE) of the liver and the presence of atrial fibrillation were determined in elderly Finnish study subjects (n = 76, mean age 73 years) from OPERA (Oulu Project Elucidating the Risk of Atherosclerosis) study cohort. Half of the study subjects had non-alcoholic fatty liver disease, whereas others did not have any known hepatic morbidity. The present study was cross-sectional by nature.ResultsThe subjects with atrial fibrillation had higher TE values (with atrial fibrillation TE = 9.3kPa, without atrial fibrillation TE = 6.3kPa, p = 0.018). When the cohort was divided to four subgroups (those without NAFLD or atrial fibrillation, with NAFLD but without atrial fibrillation, with both conditions, and with atrial fibrillation but without NAFLD), the TE value was the highest in the subjects with both conditions (5.3kPa, 7.4kPa, 10.8kPa and 7.8kPa, respectively, p = 0.019). Moreover, the higher the TE value, the more prevalent atrial fibrillation was (the atrial fibrillation prevalence by tertiles of TE 27% / 36% / 77%, p = 0.001). Likewise, the greater the TE value, the greater the left atrial diameter, a collateral of atrial fibrillation (left atrial diameters by tertiles of TE 39mm / 45mm / 48mm, p<0.001) was. All these p-values for continuous variables remained statistically significant even after adjustment for common clinically relevant risk factors.ConclusionsThere is an association between atrial fibrillation and liver stiffness. This novel association may have multiple explanations and mechanistic links, which are discussed here and need further studies, prospective studies in particular.

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Section: Discussionmentioning

confidence: 99%

Presence of atrial fibrillation is associated with liver stiffness in an elderly Finnish population

et al. 2017

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“…Gurses et al carried out a case-control study in patients with paroxysmal or persistent atrial fibrillation and preserved left ventricular systolic function. The serum levels of galectin-3 were found to be higher in patients with atrial fibrillation than in healthy control subjects [14]. Recently, Yalcin et al performed a nested-case control study including patients with paroxysmal AF who underwent delayed-enhancement magnetic resonance imaging prior to cryoballoon-based AF ablation.…”

Section: Discussionmentioning

confidence: 99%

“…Recent reports show higher circulating galectin-3 concentrations are associated with increased risk for AF development [13,14]. Although the association between AF and atrial fibrosis has been highlighted in the literature, the role of galectin-3 in the pathogenesis of these conditions has not yet been soundly elucidated [13,14]. The present study focused on determining whether serum galectin-3 levels were elevated in patients with paroxysmal AF and/or preserved left ventricular function.…”

mentioning

confidence: 99%

“…A number of studies have focused on the association between galectin-3 levels and cardiac fibrosis in heart failure [10][11] and another study has shown elevated plasma galectin-3 to be associated with incident heart failure [12]. Recent reports show higher circulating galectin-3 concentrations are associated with increased risk for AF development [13,14]. Although the association between AF and atrial fibrosis has been highlighted in the literature, the role of galectin-3 in the pathogenesis of these conditions has not yet been soundly elucidated [13,14].…”

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confidence: 99%

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Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?

Selçoki¹,

Aydın²,

Çelik³

et al. 2016

CIM

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Purpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF.Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age-and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA).Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p< 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2±3.0 mm vs. 39.6±3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p= 0.001).Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.SUPPLEMENT

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“…Gurses et al [24] showed that galectin-3 levels were higher in patients with persistent AF than in those with paroxysmal AF. The significant difference in galectin-3 levels between patients with persistent AF and those with paroxysmal AF may be due to the prominent structural remodeling of the left atrium in patients with persistent AF.…”

Section: Discussionmentioning

confidence: 99%

Galectin-3 in Acute Myocardial Infarction Patients with Atrial Fibrillation

et al. 2019

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Objective: Atrial fibrillation (AF) is common in acute myocardial infarction (AMI), and galectin-3 is possibly involved in its occurrence. Galectin-3 has been shown to play a central role in fibrosis and tissue remodeling and has a role in inflammatory and proliferative responses. The aim of our study was to measure galectin-3 levels in patients with myocardial infarction and to compare its levels in patients with or without AF, in order to investigate the potential predictive role of galectin-3 in this setting. Subjects and Methods: The study included 51 consecutive AMI patients with AF; 27 AMI patients (52.9%) had permanent/persistent AF, and 24 patients (47.1%) had paroxysmal AF. Thirty-eight consecutive AMI patients without AF were used as a control group. Blood samples were obtained from venous blood on the third day after reperfusion. Results: Patients with AF had higher levels of C-reactive protein (p < 0.01) and galectin-3 (p < 0.05) than those without AF. Patients with high galectin-3 had 4.4 times greater odds of having AF. Galectin-3 levels were lower in patients without AF (p < 0.01) than in those with permanent/persistent AF. Conclusion: AMI patients with AF had higher levels of galectin-3 than those without this arrhythmia. This biomarker of inflammation and fibrosis could be a potential target for treating AMI patients at high risk.

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Effects of Persistent Atrial Fibrillation on Serum Galectin-3 Levels

Cited by 61 publications

References 29 publications

Presence of atrial fibrillation is associated with liver stiffness in an elderly Finnish population

Presence of atrial fibrillation is associated with liver stiffness in an elderly Finnish population

Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?

Galectin-3 in Acute Myocardial Infarction Patients with Atrial Fibrillation

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