Effects of perioperative dextrose infusion on preventing postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials

Abstract

Objective The aim of this study was to systematically examine the literature and assess the effects of perioperative dextrose infusion on the prevention of postoperative nausea and vomiting (PONV) in patients following laparoscopic surgery under general anesthesia. Methods We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). Studies were eligible for inclusion if they evaluated the prevention of PONV with perioperative intravenous dextrose. Studies listed in PUBMED, Web of Science, and EMBASE databases published up to December 2020 were identified. Data were extracted and analyzed independently using a fixed-effects or random-effects model according to the heterogeneity. Results Six RCTs involving 526 patients were included. Our results showed that perioperative dextrose infusion not only reduced the incidence of PONV (risk ratio [RR] = 0.61, 95% confidence interval [CI]: 0.39–0.95; I2 = 59%) but also decreased the requirement for antiemetics compared with the control (RR = 0.53, 95% CI: 0.42–0.66; I2 = 32%). Furthermore, perioperative glucose infusion did not increase blood glucose levels compared with the control (mean difference [95% CI] = 74.55 [−20.64 to 169.73] mg/dL; I2 = 100%). Conclusion Our study reveals that perioperative dextrose infusion may reduce the risk of PONV after laparoscopic surgery. However, additional population-based RCTs are needed to confirm this finding.

The efficacy of transcutaneous electronic acupoint stimulation for improving postoperative recovery after gynecologic surgery: A systematic review and meta-analysis

“…Ultimately, 12 randomized controlled trials assessing the efficacy of TEAS in enhancing recovery for patients undergoing gynecologic surgery were included in the analysis. [18][19][20][21][22][23][24][25][26][27][28][29] Figure 1 illustrated the preferred reporting items for a systematic review and meta-analysis flow diagram in the study selection process.…”

Comparison of efficacy of intraoperative intravenous 5% dextrose versus intravenous ringer lactate for prevention of postoperative nausea and vomiting in patients undergoing elective laparoscopic cholecystectomy.

“…Laparoscopic cholecystectomy stands as the gold standard for removing the gallbladder in cases of symptomatic gallbladder disease and is the most commonly performed laparoscopic procedure globally. 1,2 It has been proved that in experienced hands laparoscopic cholecystectomy decreases hospital stay, postoperative ileus and morbidity as compare to open cholecystectomy. 2,3 The collective incidence of these complications is estimated to surpass 30% in the absence of prophylactic interventions.…”