Effects of perineural opioids on nerve conduction of N. suralis in man

Abstract

In this study the effects of agonist acting drugs (morphine sulphate, fentanyl citrate and meperidine hydrochloride) on nerve conduction were studied in 43 healthy young volunteers divided into four groups randomly. According to analgesic equivalent doses, the first group received 2 mg morphine sulphate, the second group 0.02 mg fentanyl citrate, the third group 20 mg meperidine hydrochloride, and as control the fourth group received 2 ml of saline. The latencies, amplitudes of the responses and nerve conduction velocities were obtained immediately before and every 5 min after injections up to 30 min. No significant change was observed within or among the morphine sulphate, fentanyl citrate and saline groups whereas in the meperidine hydrochloride group the amplitudes diminished significantly and this finding was still apparent at 30 min. Four of the cases displayed complete blocks. Nerve conduction velocity did not change in the other 6 cases. The significant decrement of the amplitude of the compound nerve action potential in the meperidine hydrochloride group is probably due to local anesthetic‐like action of this drug. Morphine sulphate, fentanyl citrate or saline did not show this effect.

Use of a perfusion index to confirm the presence of sciatic nerve blockade in dogs

“…Both MNCV and CMAP have been used to validate the interruption of nerve conduction following the use of drugs that hinder nerve function, such as local anesthetics (Kaya et al. ; Dalkilic et al. ; Brenner et al.…”

“…In this study, MNCV was used to confirm anesthesia following deposition of bupivacaine around the sciatic nerve. Both MNCV and CMAP have been used to validate the interruption of nerve conduction following the use of drugs that hinder nerve function, such as local anesthetics (Kaya et al 1992;Dalkilic et al 2004;Brenner et al 2010). MNCV is also used clinically as a diagnostic tool to identify peripheral nerve conduction abnormalities (Gamstorp 1970;Tankisi et al 2005).…”

Transcutaneous electrical nerve stimulation of acupuncture points enhances therapeutic effects of oral lactulose solution on opioid-induced constipation

“…Opioids exert their pharmacological and physiological effects by binding to their endogenous receptors to modulate nerve conduction. 6 The opioid system also exerts analgesic effects by affecting central nervous system sites. 7 However, the combination of opioids and m-opioid receptors in the gastrointestinal tract hinders gastrointestinal motility, prevents gastric emptying, inhibits the secretion of bile and gastric juices, suppresses faecal excretion and leads to constipation.…”

Perineural meperidine blocks nerve conduction in a dose‐related manner: a randomized double‐blind study

“…However, the results of electroneurographic human studies on the blocking effect of meperidine are contradictory. When administered perineural to the sural nerve, which is composed of sensory fibres, the local anaesthetic effects of meperidine were demonstrated 11,12 . However, a similar effect was not observed in the median nerve, containing both sensory and motor fibres 13 …”