Effects of perindopril on cardiovascular remodeling

Differential expression of angiotensin receptors in human cutaneous wound healing

“…Looking at other organs, Ang II has been shown to be involved in mechanisms of remodelling and repair in various pathophysiological settings: in the heart it takes part in left ventricular hypertrophy caused by cardiomyopathy, hypertension or myocardial infarction, 43 in the vasculature in neointima formation, 22,44 arterial remodelling in response to hypertension 45 and in the process of atherosclerosis, 46 in the kidney in interstitial fibrosis originating from membranous nephropathy, diabetic nephropathy or IgA nephropathy, 47 and in fibrosis in the lung, liver and pancreas 48–50 …”

Prolonged treatment with the at1 receptor blocker, valsartan, increases small and large artery compliance in uncomplicated essential hypertension

“…Accumulating evidence suggests that abnormalities in arterial compliance can be used as early, subclinical markers for future development of cardiovascular events and are a useful tool to estimate the extent of arterial wall damage. 6 -10 Angiotensin II is a powerful factor in development of elevated BP and tissue damage 10 and its blockade should play a major role in remodeling of the vascular wall by reversing damage in patients with essential hypertension.…”

Angiotensin Receptor Blockade and Arterial Compliance in Chronic Kidney Disease: A Pilot Study

“…In the general population, agents that interrupt the RAAS, such as ACE-inhibitors and ARBs, seem to be especially beneficial [10, 11, 23, 24]. The favorable effects of inhibiting angiotensin II’s structural remodeling effects was shown in a study by Schiffrin et al [25] in which subjects with essential hypertension were randomized to either the ARB, losartan, or the β-blocker, atenolol.…”