Effects of perinatal undernourishment on neuronal development of the facial motor nucleus in the rat

Pérez-Torrero, Esther; Torrero, Carmen; Salas, Manuel

doi:10.1016/s0006-8993(01)02500-8

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…In this context our data agree with studies showing that distal dendritic branches are more related to the reception of stimuli underlying experience, while other neuronal regions are involved in cue integration, intracellular biochemical processes and generation of efferent axonal messages for interneuronal communication (Marin-Padilla,1975;Andrade et al, 1996;Perez-Torrero et al, 2001).…”

Section: Discussionsupporting

confidence: 91%

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

Rubio¹,

Torrero²,

Regalado³

et al. 2004

Nutritional Neuroscience

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Newborn of altricial species maintain functional gustatory communication with the mother because the neural substrate and the capacity to discriminate and promote gustofacial responses are already operating. Because little is known about the effects of perinatal food restriction upon gustatory neuronal brain stem structures, we characterized neuronal Golgi-Cox alterations of the solitary tract rostral portion (NSTr) where gustatory information is known to convey in neonatal Wistar rats. Pre-and neonatally undernourished rats exhibited a general reduction in the number and extension of distal dendrites particularly in small neurons but little effect upon perikarya measurements of the NSTr neuronal population. By contrast, in nutritional and sensory rehabilitated rats the number of distal dendrites increased, although the dendritic extensions were less affected compared to perinatally underfed and control subjects. The data indicate that perinatal food restriction interferes with the NSTr dendritic arbor organization, while nutritional and sensorial rehabilitation given by normally lactating dams induced plastic changes presumably modifying the integrative processes underlying early taste discriminative capabilities. Moreover, since perinatal food restriction is a powerful stressor influence and the NST forms a part of a complex system underlying adaptive stress responses, the neuronal alterations observed here may be partly due to this noxious perinatal influence.

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Section: Discussionsupporting

confidence: 91%

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

Rubio¹,

Torrero²,

Regalado³

et al. 2004

Nutritional Neuroscience

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“…The GFR alterations in response to tastants found in the present study are in line with neuronal hypoplasia and the disorganization of the dendritic tree and spines observed along the relay nuclei of the gustatory and motor facial nucleus [7,13,15,36,37]. In this regard, it is known that descending input from the insular cortex, lateral hypothalamus, and central amygdale modulate the brainstem sensory and motor mechanisms of the newborn to produce fluid and food intake, nipple attachment, and the GFR integration that seems to be disrupted in the UG animals studied here [19,[38][39][40][41].…”

Section: Discussionsupporting

confidence: 87%

“…Perinatal undernutrition mainly interferes with the anatomical organization of central nervous system (CNS) areas which undergo a phase of postnatal cell proliferation; these areas include the cerebral and cerebellar cortices, the hippocampus, central amygdaloid nucleus, olfactory bulb, and solitary tract nucleus, and they participate in the head movements, mouth opening and closing, chewing, food ingestion, and chemosensory CNS integration [8,[9][10][11][12][13]. Early undernutrition affects neuronal development by reducing the cell number and their dendritic branching, and by the formation of spines with small perikarya alterations that interfere with their connectivity and neuronal interactions [7,8,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Development of the Gusto Facial Reflex in Perinatally Undernourished Rats

Salas¹,

Torrero²,

Regalado³

et al. 2012

JBBS

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In the rat, the taste system plays a critical role in motivating the animal to consume nutrients and avoid toxic substances. In neonatal rat the orofacial movements can be modified by the application of sucrose and quinine in the mouth, producing ingestion or rejection responses, respectively, but there is no information available on the gusto facial reflexes (GFR) under perinatal fasting. The aim of the present study was to determine how undernutrition can affect the development of orofacial responses to sucrose, quinine, and NaCl during early development. Pregnant dams were undernourished by being given 50% of a balanced diet from G6 to G12, 60% from G13 -G18, and 100% from G 19-G21. On postpartum days 0 -9, prenatally underfed (UG) pups continued the undernourishment by remaining for 12 h with a foster dam and 12 h with a nipple-ligated mother. Stimuli were presented as a single droplet of sucrose (S), sodium chloride (NaCl), quinine hydrochloride (Q), and water (W) onto the lips at 1, 3, 5, 7, and 9 days of age, and mouth-opening frequency (MO) and lip-licking frequency (LL) were analyzed. The results show consistent effects associated with age, but not with diet, except in the cases of 0.01 M Q, which provoked in the UG subjects increased MO and the reduction of LL, and 0.1 M Q, which consistently reduced both responses. Moreover, S provoked increases in both MO and LL at 0.1 M while NaCl and water elicited minimal effects on GFR. These data suggest that perinatal undernutrition affects the basic components of the gustatory system necessary to produce GFR in the first postnatal days by possibly interfereing with the integration of taste input for food learning and the hedonic aspects of gustatory cues.

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“…After birth, these pups were fed by interchanging a pair of normally lactating mothers every 12 h as described elsewhere (Lynch 1976;Pérez-Torrero et al 2001). After weaning on day 25, pups had free access to water and solid food.…”

Section: Dietary Treatmentmentioning

confidence: 99%

“…During the perinatal period, nutritional deprivation produces neuronal and functional alterations that may remain throughout life (Leuba and Rabinowicz 1979;Barker and Clark 1997;Pérez-Torrero et al 2001Bedi 2003;Cordero et al 2003). This damage depends on the type of deprivation and stage of brain development, and it also seems to be specific for each mammalian species (Dobbing 1971;Dobbing and Sands 1979;Debassio and Kemper 1985;Royland et al 1991;Peeling and Smart 1994;Robinson et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Early undernourishment interferes with the maternal aggressive response triggered by an intruder entering the homing cage

Pérez-Torrero

Salas²

2007

Nutritional Neuroscience

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The maternal aggressive response (MAR) against intruders is temporarily expressed during lactation in association with the rearing and protection of offspring to promote their survival and growth in the nest. This normal component of maternal behaviour requires both the hormonal changes occurring at the end of pregnancy and the presence of pups for its establishment. Because early food restriction in the rat results in long-term maternal deficiencies, we analysed in Wistar rats the effects of perinatal undernutrition on the MAR to an intruder at days 1, 4, and 8 postpartum. The data showed that undernourished dams exhibited significant reductions of sniffing frequency on days 4 and 8 and significant increases of biting on day 4 and of lateral attacks on postpartum days 4 and 8. The finding of an altered MAR during the lactating period may be relevant for the survival and long-term behavioural development of the progeny.

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Effects of perinatal undernourishment on neuronal development of the facial motor nucleus in the rat

Cited by 17 publications

References 40 publications

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

Development of the Gusto Facial Reflex in Perinatally Undernourished Rats

Early undernourishment interferes with the maternal aggressive response triggered by an intruder entering the homing cage

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