Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats

Trezza, Viviana; Campolongo, Patrizia; Cassano, Tommaso; Macheda, Teresa; Dipasquale, Pasqua; Carratù, Maria Rosaria; Gaetani, Silvana; Cuomo, V.

doi:10.1007/s00213-008-1162-3

Cited by 123 publications

(131 citation statements)

References 71 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…Exposed offspring showed reduced body weight at birth (Abel et al, 1981;Abel et al, 1980). As with humans, young rats exposed to THC throughout pre-and postnatal development had increased ultrasonic vocalizations (cries) when isolated, indicative of increased anxiety and potentially analogous to increased irritability in human infants (Trezza et al, 2008a). In this same study, rats showed deficits in social behaviors during adolescence and elevated anxiety in adulthood.…”

Section: Cannabis/delta-9-tetrahydrocannabinolmentioning

confidence: 78%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

327

241

View full text Add to dashboard Cite

Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, often differ from their effects on mature systems. In this review, we describe current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates (among other drugs) produce alterations in neurodevelopmental trajectory. We focus both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies. Early studies of fetal exposures focused on classic teratological methods that are insufficient for revealing more subtle effects that are nevertheless very behaviorally relevant. Modern mechanistic approaches have informed us greatly as to how to potentially ameliorate the induced deficits in brain formation and function, but conclude that better delineation of sensitive periods, dose-response relationships, and long-term longitudinal studies assessing future risk of offspring to exhibit learning disabilities, mental health disorders, and limited neural adaptations are crucial to limit the societal impact of these exposures.

show abstract

Section: Cannabis/delta-9-tetrahydrocannabinolmentioning

confidence: 78%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

327

241

View full text Add to dashboard Cite

show abstract

“…An increased retrospective perception of parents neglect in drug users may have been simply influenced by drug-induced psychological and emotional derangement [Rubino and Parolaro, 2008;Trezza et al, 2008]. In fact, SS genotype individuals may have underestimated their parents' care because of drugs effects.…”

Section: Discussionmentioning

confidence: 94%

Relevance of perceived childhood neglect, 5‐HTT gene variants and hypothalamus–pituitary–adrenal axis dysregulation to substance abuse susceptibility

Gerra

Zaimovic²,

Castaldini³

et al. 2009

American J of Med Genetics Pt B

View full text Add to dashboard Cite

The hypotheses of (1) gene x environment interaction in the susceptibility to experiment with drugs and (2) hypothalamus-pituitary-adrenal (HPA) axis involvement in mediating the effects of early adverse experiences and gene variants affecting serotonin function on substance abuse vulnerability were tested by investigating in 187 healthy adolescents the possible relevance of 5-HTT "S" polymorphism, childhood parental neglect reported retrospectively and HPA axis function to the susceptibility to experiment with illicit drugs. Higher frequency of the 5-HTT SS genotype seems to be associated with an increased susceptibility to use illegal psychotropic drugs among the adolescents. At the same time, reduced maternal care perception was found to represent a key intermediate factor of the association between SS polymorphism and drug use, suggesting that genetic factors and parental behavior concur to drug use susceptibility. Our results also confirm the relationship between basal plasma levels of cortisol and adrenocorticotropic hormone (ACTH) on the one hand, and retrospective measures of neglect during childhood: the higher the mother and father neglect CECA-Q scores, the higher the plasma levels of the two HPA hormones. Such positive relationship has been proved to be particularly effective and important when associated to the S-allele, both in homozygote and heterozygote individuals. However, when tested together with genotype and parental neglect, the effect of HPA hormones such as cortisol and ACTH was not found to improve significantly the explanatory power of the risk model.

show abstract

“…The animals in a pair did not differ more than 10 g in body weight; furthermore, they were housed in different cages and that therefore had no previous common social experience from the arrival in our Facility till the day of testing (File, 1980;Trezza et al, 2008).…”

Section: Behavioral Testsmentioning

confidence: 99%

Simvastatin Treatment Highlights a New Role for the Isoprenoid/Cholesterol Biosynthetic Pathway in the Modulation of Emotional Reactivity and Cognitive Performance in Rats

Segatto¹,

Manduca²,

Lecis³

et al. 2013

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. Three-month-old male Wistar rats treated for 21 days with simvastatin or vehicle were tested in the social interaction, elevated plus-maze, and inhibitory avoidance tasks; after behavioral testing, the amygdala, hippocampus, prefrontal cortex, dorsal, and ventral striatum were dissected out for biochemical assays. In order to delve deeper into the molecular mechanisms underlying the observed effects, primary rat hippocampal neurons were used. Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plusmaze test, and improves memory consolidation in the inhibitory avoidance task. These effects are accompanied by imbalances in the activity of specific prenylated proteins, Rab3 and RhoA, involved in neurotransmitter release, and synaptic plasticity, respectively. Taken together, the present findings indicate that the isoprenoid/cholesterol biosynthetic pathway is critically involved in the physiological modulation of both emotional and cognitive processes in rodents.

show abstract

Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats

Cited by 123 publications

References 71 publications

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Relevance of perceived childhood neglect, 5‐HTT gene variants and hypothalamus–pituitary–adrenal axis dysregulation to substance abuse susceptibility

Simvastatin Treatment Highlights a New Role for the Isoprenoid/Cholesterol Biosynthetic Pathway in the Modulation of Emotional Reactivity and Cognitive Performance in Rats

Contact Info

Product

Resources

About