Effects of perinatal dioxin exposure on learning abilities of 8-year-old children in Vietnam

Ngoc, Thao Pham; Tong, Hoang Van; Nishijo, Muneko; Ngoc, Nghi Tran; Thi, Hoa Vu; Van, Luong Hoang; Hai, Anh Tran; Nishino, Yoshikazu; Nishijo, Hisao

doi:10.1016/j.ijheh.2019.09.010

Cited by 14 publications

(13 citation statements)

References 39 publications

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“…Nine articles published by our group on neurodevelopment in infants and children of various ages from the Da Nang cohort [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] are presented, with the age and sex of the subjects and evaluation methods in Table 1 for studies from 4 months to 3 years of age and in Table 2 for studies from 5 to 8 years of age.…”

Section: Resultsmentioning

confidence: 99%

“…In the follow-up studies of the Duisburg birth cohort, the authors used only TEQ-PCDD/Fs as dioxin exposure markers (13.55 of pg TEQ/g lipid of the GM and 12.45–14.75 pg TEQ/g lipid at 95% confidence intervals in blood samples) [ 17 ] and showed no association between TCDD and behavioral indices in children at 2 years [ 18 ], 6–8 years [ 19 ], or 9–10 years [ 17 , 20 ]. Only the Da Nang birth cohort studies that showed associations between neurodevelopmental markers and TCDD and other PCDD/F congeners in their follow-up studies until 8 years of age [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] were thus selected for the present review.…”

Section: Methodsmentioning

confidence: 99%

“…We therefore followed up infants whose mother’s milk samples were examined in our survey in Da Nang [ 1 ]. Our investigation of this Da Nang birth cohort, from 4 months to 8 years of age, identified adverse effects of dioxin exposure on infant and child neurodevelopment in several age groups, using standardized test batteries and parent rating scales for different aspects of neurodevelopment [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…At the same age, girls in the high TCDD group showed higher unusual behavioral scores, indicating increased autistic behavior associated with TCDD exposure, but not TEQ-PCDD/F exposure [ 10 ]. Moreover, at 8 years of age, boys with high TCDD showed reading learning disabilities, lower language achievement test scores, and poor reading skills [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental Effects of Perinatal TCDD Exposure Differ from Those of Other PCDD/Fs in Vietnamese Children Living near the Former US Air Base in Da Nang, Vietnam

Tran

Pham-The

Pham

et al. 2023

Toxics

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This study reports that children exposed to 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), the major toxin in Agent Orange, from the breast milk of mothers residing near the former Da Nang US air base in Vietnam may have specific alterations in higher brain functions, resulting in social and communication deficits, including autism spectrum disorder (ASD). After the age of 8 years, girls with high TCDD showed increased attention deficit hyperactivity disorder (ADHD)-like behaviors and altered mirror neuron activity, which is often observed in children with ASD. However, no significant relationship between autistic traits and toxic equivalency values of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (TEQ-PCDD/Fs) was found in these children. Notably, boys with high levels of TEQ-PCDD/Fs showed poor language and motor development in the first 3 years of life, although boys with high TCDD levels did not. However, at 8 years of age, boys with high TCDD showed reading learning difficulties, a neurodevelopmental disorder. These findings suggest that perinatal TCDD exposure impacts social–emotional cognitive functions, leading to sex-specific neurodevelopmental disorders—learning difficulty in boys and ADHD in girls. Future studies with a greater number of children exposed to high levels of TCDD are necessary to estimate the threshold values for neurodevelopmental effects.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental Effects of Perinatal TCDD Exposure Differ from Those of Other PCDD/Fs in Vietnamese Children Living near the Former US Air Base in Da Nang, Vietnam

Tran

Pham-The

Pham

et al. 2023

Toxics

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“…Exercise is a complex physiological stressor that is a function of optimal performance of the heart myocardium, made up of cardiomyocytes, to deliver energy and oxygen requirements to cells 78 . Notwithstanding other potential factors that affect exercise tolerance such as learning that may be influenced by TCDD 79 . Mitochondria are crucial for cardiomyocyte survival and function and make up 20–30% of the cell volume of cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood

Gannes

Koch

Puga

et al. 2021

Sci Rep

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Congenital heart disease (CHD) is the most common congenital abnormality. A precise etiology for CHD remains elusive, but likely results from interactions between genetic and environmental factors during development, when the heart adapts to physiological and pathophysiological conditions. Further, it has become clearer that early exposure to toxins that do not result in overt CHD may be associated with adverse cardiac outcomes that are not manifested until later life. Previously, interference with endogenous developmental functions of the aryl hydrocarbon receptor (AHR), either by gene ablation or by in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent AHR ligand, was shown to cause structural, molecular and functional cardiac abnormalities and altered heart physiology in mouse embryos. Here, we show that continuous exposure to TCDD from fertilization throughout adulthood caused male mice to underperform at exercise tolerance tests compared to their control and female counterparts, confirming previous observations of a sexually dimorphic phenotype. Renin-angiotensin stimulation by angiotensin II (Ang II) caused measurable increases in blood pressure and left ventricle mass, along with decreased end diastolic volume and preserved ejection fraction. Interestingly, TCDD exposure caused measurable reductions in the myocardial hypertrophic effects of Ang II, suggesting that endogenous AHR signaling present in adulthood may play a role in the pathogenesis of hypertrophy. Overall, the findings reported in this pilot study highlight the complex systems underlying TCDD exposure in the development of cardiac dysfunction in later life.

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Serum dioxin concentrations in military workers at three dioxin-contaminated airbases in Vietnam

et al. 2021

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Effects of perinatal dioxin exposure on learning abilities of 8-year-old children in Vietnam

Cited by 14 publications

References 39 publications

Neurodevelopmental Effects of Perinatal TCDD Exposure Differ from Those of Other PCDD/Fs in Vietnamese Children Living near the Former US Air Base in Da Nang, Vietnam

Neurodevelopmental Effects of Perinatal TCDD Exposure Differ from Those of Other PCDD/Fs in Vietnamese Children Living near the Former US Air Base in Da Nang, Vietnam

Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood

Serum dioxin concentrations in military workers at three dioxin-contaminated airbases in Vietnam

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