Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats

Kiss, P.; Szogyi, Donat; Reglődi, Dóra; Horváth, Gábor; Farkas, József; Lubics, Andrea; Tamás, Andrea; Atlasz, Tamás; Szabadfi, Krisztina; Babai, Norbert; Gábriel, Róbert; Koppán, Miklós

doi:10.1016/j.brainres.2008.12.018

Cited by 32 publications

(33 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Samples for measurements derived from at least six tissue blocks prepared from at least three animals (n=2-5 measurements from one tissue block). Since regional differences have been described in light-induced retinal lesions (Tanito et al 2008), we standardized the area for measurements for within 1 mm from the optic disc, according to our earlier studies (Kiss et al 2009). The following parameters were measured: (1) cross-section of the retina from the outer limiting membrane to the inner limiting membrane (OLM-ILM); (2) the width of the outer and inner nuclear and outer and inner plexiform layers (ONL, INL, OPL, and IPL, respectively); (3) the number of cells in the ONL/500 µm 2 ; (4) the number of cells in the INL/500 µm 2 ; (5) the number of cells/100-µm-section length in the ganglion cell layer (GCL).…”

Section: Methodsmentioning

confidence: 99%

Effects of PACAP in UV-A Radiation-Induced Retinal Degeneration Models in Rats

et al. 2010

Self Cite

View full text Add to dashboard Cite

The retina is constantly exposed to ultraviolet (UV) light with different wavelengths, which may lead to chronic UV-induced retinal injury. In our previous studies, we have shown the protective effects of pituitary adenylate cyclase activating polypeptide (PACAP) in toxic and ischemic retinal injuries. The aim of the present study was to investigate the effects of PACAP in UV-A-induced retinal lesion. We used diffuse UV-A radiation (315-400 nm) to induce acute retinal damage over a short period of exposure. Using standard histological (morphological and morphometrical) analysis, we assessed the actions of intravitreal PACAP (100 pmol/5 µl) treatment on acute UV-A-induced retinal damage. We measured the thickness of nuclear and plexiform layers as well as the number of cells in the outer nuclear and inner nuclear layers and in the ganglion cell layer. Outer limiting membrane-inner limiting membrane distances in the cross-section of the retina were also examined. Our results show that UV-A light-induced retinal damage led to severe degeneration in the photoreceptor layer, and in the outer and inner nuclear layers. Alteration in the plexiform layers was also observed. We found that post-irradiation PACAP treatment significantly attenuated the UV-A-induced retinal damage. Our results provide the basis for future clinical application of PACAP treatment in retinal degeneration and may have clinical implications in several ophthalmic diseases.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of PACAP in UV-A Radiation-Induced Retinal Degeneration Models in Rats

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies have revealed that the chronic placental insufficiency (CPI) or umbilical cord occlusion to which fetus may be exposed to result in fatal hypoxenima [22] leading to synaptic dysfunction that triggers damage in neonates resulting in neurodegeneration [23]. Maternal hormonal disturbances also have adverse effect on fetus.…”

Section: Introductionmentioning

confidence: 99%

Role of early life exposure and environment on neurodegeneration: implications on brain disorders

Modgil

Lahiri

Sharma

et al. 2014

Transl Neurodegener

109

View full text Add to dashboard Cite

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively and varying molecular mechanisms have been proposed for onset of such diseases. Although genetic analysis of these diseases has also been described, yet the mechanisms governing the extent of vulnerability to such diseases remains unresolved. Recent studies have, therefore, focused on the role of environmental exposure in progression of such diseases especially in the context of prenatal and postnatal life, explaining how molecular mechanisms mediate epigenetic changes leading to degenerative diseases. This review summarizes both the animal and human studies describing various environmental stimuli to which an individual or an animal is exposed during in-utero and postnatal period and mechanisms that promote neurodegeneration. The SNPs mediating gene environment interaction are also described. Further, preventive and therapeutic strategies are suggested for effective intervention.

show abstract

“…Using the same battery of tests, we are able to make comparative analysis based on experiments carried out in the last 10 years [38]. We found that neonatal hypoxia and asphyxia led to extremely severe retardations in our developmental model [31,33]. Rats undergoing perinatal asphyxia or exposure to hypoxic environment after unilateral carotid ligation had marked delays in the appearance of most reflexes and even 4-5 days delay in the appearance of some maturation signs.…”

Section: Discussionmentioning

confidence: 96%

“…Possible gender differences were also evaluated. Tests were based on previous descriptions [31,32,34]. Weight was measured daily until 3 weeks of age.…”

Section: Neurobehavioral Testingmentioning

confidence: 99%

“…It has been shown that reflex ontogeny in rodents is influenced by several factors such as undernutrition, maternal care, toxic agents, environmental enrichment, genetic background [22][23][24][25][26][27][28][29][30]. We have previously described that perinatal hypoxic and toxic injuries remarkably delay the neurobehavioral development but 3-hr-long maternal separation induces only slight changes [31][32][33][34]. Ten et al reported for the first time that short-term neuro-functional performance correlate with long-term functional deficits and suggested the predictive value of early evaluation [35].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation