Effects of Peptides of the Secretin‐Glucagon Family and Cyclic Nucleotides on Tyrosine Hydroxylase Activity in Sympathetic Nerve Endings

Schwarzschild, Michael A.; Zigmond, Richard E.

doi:10.1111/j.1471-4159.1991.tb08165.x

Cited by 19 publications

(10 citation statements)

References 31 publications

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“…The stimulatory effect of VIP on cAMP, cGMP, and AA-NAT is potentiated by ␣ 1 -AR agonists (Ho et al, 1987b;Yuwiler, 1987;Chik et al, 1988). However, it has been suggested that, in addition to its postsynaptic effects on pinealocytes, VIP may stimulate TH activity in the sympathetic nerve endings (Schwarzschild and Zigmond, 1991). A study comparing the effects of VIP and ISO on the same culture of rat pinealocytes has shown that VIP is very effective in stimulating MEL synthesis (EC 50 ϭ 0.11 nM), but that at optimal doses (1 to 10 nM) its effect is approximately 2 to 3 times lower than that induced by optimal doses (1 to 10 M) of a ␤ 1 -AR agonist .…”

mentioning

confidence: 98%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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mentioning

confidence: 98%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…Subsequently, STAT proteins translocate to the nucleus and bind to conserved genomic regulatory sequences to rapidly activate gene transcription [42], [43]. The cytokines also activate components of other intracellular signaling pathways, including Ras, mitogen-activated protein kinase (MAPK), and the Fos-Jun (AP-1) transcription factors [44]–[46], and activate direct interaction between STAT1 and AP-1 [47]. This supports our AP-1 motif detected by rGADEM in the STAT1 enriched regions.…”

Section: Resultsmentioning

confidence: 99%

An Integrated Pipeline for the Genome-Wide Analysis of Transcription Factor Binding Sites from ChIP-Seq

Mercier

Droit

et al. 2011

PLoS ONE

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ChIP-Seq has become the standard method for genome-wide profiling DNA association of transcription factors. To simplify analyzing and interpreting ChIP-Seq data, which typically involves using multiple applications, we describe an integrated, open source, R-based analysis pipeline. The pipeline addresses data input, peak detection, sequence and motif analysis, visualization, and data export, and can readily be extended via other R and Bioconductor packages. Using a standard multicore computer, it can be used with datasets consisting of tens of thousands of enriched regions. We demonstrate its effectiveness on published human ChIP-Seq datasets for FOXA1, ER, CTCF and STAT1, where it detected co-occurring motifs that were consistent with the literature but not detected by other methods. Our pipeline provides the first complete set of Bioconductor tools for sequence and motif analysis of ChIP-Seq and ChIP-chip data.

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“…It lowers the production of cGMP levels in a wide range of tissues, with negligible effect on cAMP levels (Mulsch et al 1988). 8-Bromoguanosine 3 0 ,5 0 -cyclic monophosphate sodium salt monohydrate (8-Br-cGMP) is a cell permeable nonhydrolyzable derivative of cGMP (Schwarzschild and Zigmond 1991). Staurosporine is a potent, cell permeable, broad spectrum inhibitor of protein kinases (Rüegg and Burgess 1989).…”

Section: Chemicalsmentioning

confidence: 99%

Mechanisms of xylanase-induced nitric oxide and phosphatidic acid production in tomato cells

Lanteri

Lamattina²,

Laxalt³

2011

Planta

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The second messenger nitric oxide (NO), phosphatidic acid (PA) and reactive oxygen species (ROS) are involved in the plant defense response during plant-pathogen interactions. NO has been shown to participate in PA production in response to the pathogen-associated molecular pattern xylanase in tomato cell suspensions. Defense responses downstream of PA include ROS production. The goal of this work was to study the signaling mechanisms involved in PA production during the defense responses triggered by xylanase and mediated by NO in the suspension-cultured tomato cells. We analyzed the participation of protein kinases, guanylate cyclase and the NO-mediated posttranslational modification S-nitrosylation, by means of pharmacology and biochemistry. We showed that NO, PA and ROS levels are significantly diminished by treatment with the general protein kinase inhibitor staurosporine. This indicates that xylanase-induced protein phosphorylation events might be the important components leading to NO formation, and hence for the downstream regulation of PA and ROS levels. When assayed, a guanylate cyclase inhibitor or a cGMP analog did not alter the PA accumulation. These results suggest that a cGMP-mediated pathway is not involved in xylanase-induced PA formation. Finally, the inhibition of protein S-nitrosylation did not affect NO formation but compromised PA and ROS production. Data collectively indicate that upon xylanase perception, cells activate a protein kinase pathway required for NO formation and that, S-nitrosylation-dependent mechanisms are involved in downstream signaling leading to PA and ROS.

show abstract

Effects of Peptides of the Secretin‐Glucagon Family and Cyclic Nucleotides on Tyrosine Hydroxylase Activity in Sympathetic Nerve Endings

Cited by 19 publications

References 31 publications

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

An Integrated Pipeline for the Genome-Wide Analysis of Transcription Factor Binding Sites from ChIP-Seq

Mechanisms of xylanase-induced nitric oxide and phosphatidic acid production in tomato cells

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