Effects of peppermint oil and caraway oil on gastroduodenal motility

Micklefield, G. H.; Greving, I.; May, B.

doi:10.1002/(sici)1099-1573(200002)14:1<20::aid-ptr542>3.0.co;2-z

Cited by 80 publications

(75 citation statements)

References 12 publications

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“…In physiological testing, ginger increases fasting antral contractions and the gastric motor response to eating (Micklefield et al, 1999). Furthermore, ginger reverses cisplatin-induced delays in gastric emptying in animal models (Sharma and Gupta, 1998).…”

Section: Discussionmentioning

confidence: 99%

Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins

Gonlachanvit

Chen

Hasler³

et al. 2003

J Pharmacol Exp Ther

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Acute hyperglycemia evokes gastric slow wave dysrhythmias via endogenous prostaglandin generation. Ginger exhibits slow wave antiarrhythmic effects in other models, but its actions on hyperglycemia-evoked gastric dysrhythmias are unexplored. We hypothesized that ginger prevents disruption of slow wave rhythm by acute hyperglycemia via inhibition of prostaglandin production but not its actions. Twenty-two healthy humans underwent fasting electrogastrography during hyperglycemic clamping to 250 to 290 mg/dl after double-blind placebo or ginger root (1 g). Responses were compared with the prostaglandin E 1 analog misoprostol (400 g). Dominant frequencies (DF) and the percentage of recording times in the bradygastric [0.5-2 cycles/min (cpm)], normal (2-4 cpm), and tachygastric (4 -9 cpm) frequency ranges were analyzed. After placebo, hyperglycemia reduced normal 2 to 4 cpm activity from 94.4 Ϯ 2.6 to 66.0 Ϯ 10.4%, increased the DF from 2.96 Ϯ 0.04 to 4.09 Ϯ 0.45 cpm, and increased tachygastria from 2.0 Ϯ 1.4 to 29.3 Ϯ 10.7% (P Ͻ 0.05). Hyperglycemia effects on normal activity (77.3 Ϯ 8.3%), DF (3.46 Ϯ 0.37 cpm), and tachygastria (15.6 Ϯ 8.6%) were significantly reduced by ginger (P Ͻ 0.05). Misoprostol evoked decreases in normal activity from 95.4 Ϯ 2.0 to 81.7 Ϯ 3.0% and increases in tachygastria from 3.1 Ϯ 1.6 to 11.2 Ϯ 2.4% (P Ͻ 0.05). However, ginger did not correct these abnormalities versus placebo (P ϭ N.S.). In conclusion, acute hyperglycemia evokes gastric slow wave dysrhythmias that are prevented by ginger root. Conversely, the compound has no effect on dysrhythmias elicited by a prostaglandin E 1 analog, indicating that ginger likely acts to blunt production of prostaglandins rather than inhibiting their action. These findings suggest novel mechanisms for the traditional Chinese herbal remedy ginger.

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Section: Discussionmentioning

confidence: 99%

Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins

Gonlachanvit

Chen

Hasler³

et al. 2003

J Pharmacol Exp Ther

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“…Peppermint oil and menthol are carminative and gastric sedative, which relax gastrointestinal muscle both in vitro and in vivo [16,17,18,19]. Using a receptor binding assay, Hawthorn et al [20] demonstrated competitive antagonism with L-menthol of [ 3 H]-nitrendipine and the dihydropyridine radioligand [ 3 H]-(+)-PN200-110 binding to cardiac, neuronal and intestinal smooth muscle.…”

Section: Discussionmentioning

confidence: 98%

Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers

Gelal

Guven

Balkan

et al. 2003

European Journal of Clinical Pharmacology

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Objectives: The present study was undertaken to determine whether a single oral dose of menthol affects the metabolism of caffeine, a cytochrome P 450 1A2 (CYP1A2) substrate, and pharmacological responses to caffeine in people. Methods: Eleven healthy female subjects participated in a randomized, double-blind, two-way crossover study, comparing the kinetics and effects of a single oral dose of caffeine (200 mg) in coffee taken together with a single oral dose of menthol (100 mg) or placebo capsules. Serum caffeine concentrations and cardiovascular and subjective parameters were measured throughout the study. Results: Co-administration of menthol resulted in an increase of caffeine t max values from 43.6±20.6 min (mean±SD) to 76.4±28.0 min (P<0.05). The C max values of caffeine were lower in the menthol phase than in the placebo phase, but this effect was not statistically significant (P=0.06). (AUC) 0-24 , (AUC) 0-¥ , terminal half-life and oral clearance were not affected by menthol.Only nine subjects' cardiovascular data were included in the analysis because of technical problems during the measurements. After caffeine, heart rate decreased in both treatment phases. The maximum decrease in heart rate was less in the menthol phase ()8.9±3.9 beats/min) than in the placebo phase ()13.1±2.1 beats/min) (P=0.024). There were no statistically significant differences in systolic and diastolic blood pressures between the two treatments. Conclusions: We conclude that a single oral dose of pure menthol (100 mg) delays caffeine absorption and blunts the heart-rate slowing effect of caffeine, but does not affect caffeine metabolism. The possibility that menthol slows the absorption of other drugs should be considered.

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“…In fact, PO is a well -known, harmless substance that inhibits GI smooth muscle contractility 15) . As its major constituent is menthol, PO relaxes GI smooth muscle tissues by reducing the influx of calcium into the muscle cells 16) .…”

Section: Ofmentioning

confidence: 99%

Utility of Peppermint Oil for Endoscopic Diagnosis of Gastric Tumors

Hikichi

Irisawa

Satō

et al. 2011

Fukushima J. Med. Sci.

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:We investigated whether peppermint oil (PO) is useful for endoscopic diagnosis of gastric tumors without magnifying endoscopy. Twenty -six patients diagnosed with gastric tumors were examined. Endoscopic images were recorded by white light (WL) and narrow band imaging (NBI) without magnifying endoscopy. After PO administration, images were recorded again by WL and NBI (PO+WL and PO+NBI). The clarity of tumor margins and the effect of PO on the clarity of tumor margins were scored. The mean scores for clarity of tumor margins were 3.6 points in WL, 4 in NBI, 4.3 in PO+WL, and 4.3 in PO+NBI. The scores of WL and NBI showed a tendency to rise by PO. The mean scores for the effect of PO on the clarity of tumor margins were 2.7 in WL and 2.5 in NBI. Therefore, we conclude that PO is useful for endoscopic diagnosis of the margin of gastric tumors.

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Effects of peppermint oil and caraway oil on gastroduodenal motility

Cited by 80 publications

References 12 publications

Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins

Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins

Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers

Utility of Peppermint Oil for Endoscopic Diagnosis of Gastric Tumors

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