Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity

Mao, Qing-Qiu; Ip, Siu‐Po; Ko, Kam-Ming; Tsai, Sam-Hip; Xian, Yan‐Fang; Che, Chun‐Tao

doi:10.1016/j.jep.2009.04.019

Cited by 53 publications

(54 citation statements)

References 33 publications

(40 reference statements)

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“…Using this model, our findings indicated that mice subjected to 6-week CUMS procedure consumed less sucrose solution when compared with nonstressed controls (Mao et al, 2009b). Long-term treatment with a glycoside-rich extract of peony (80 or 160 mg/kg/day) during the 6 weeks of CUMS exposure significantly increased sucrose consumption, as compared with the vehicle-treated CUMSmice (Mao et al, 2009b). Similar results were obtained in another study using rats.…”

Section: Anti-depressant-like Effects Of Peonysupporting

confidence: 83%

“…Several studies have suggested that CUMS can induce long-term behavioral disturbances resembling the clinical symptoms observed in patients suffered from depression (Katz et al, 1981;Willner, 1997Willner, , 2005, and that the CUMS model is useful for evaluating the efficacy of anti-depressant drug candidates through behavioral tests such as the tail suspension test, sucrose preference test, and open-field test (Katz et al, 1981;Willner, 1997Willner, , 2005. In this regard, our results indicated that a 24-day CUMS exposure significantly prolonged the immobilization time of mice in the tail suspension test, while treatment with a glycoside-rich extract of peony (80 or 160 mg/kg/day) during the course of CUMS resulted in a significant reversal of the changes in immobilization time (Mao et al, 2009b). Wang et al, (2010) reported similar observations on the anti-depressant effect of peony root.…”

Section: Anti-depressant-like Effects Of Peonymentioning

confidence: 59%

“…Anhedonia, a core symptom of human major depression, can be mimicked by inducing a decrease in responsiveness to rewards reflected by a reduced consumption and/or preference of sweetened solutions. Using this model, our findings indicated that mice subjected to 6-week CUMS procedure consumed less sucrose solution when compared with nonstressed controls (Mao et al, 2009b). Long-term treatment with a glycoside-rich extract of peony (80 or 160 mg/kg/day) during the 6 weeks of CUMS exposure significantly increased sucrose consumption, as compared with the vehicle-treated CUMSmice (Mao et al, 2009b).…”

Section: Anti-depressant-like Effects Of Peonymentioning

confidence: 77%

See 2 more Smart Citations

Anti-depressant-like effect of peony: a mini-review

Mao¹,

Ip²,

Xian³

et al. 2011

Pharmaceutical Biology

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Section: Anti-depressant-like Effects Of Peonysupporting

confidence: 83%

Section: Anti-depressant-like Effects Of Peonymentioning

confidence: 59%

Section: Anti-depressant-like Effects Of Peonymentioning

confidence: 77%

See 1 more Smart Citation

Anti-depressant-like effect of peony: a mini-review

Mao¹,

Ip²,

Xian³

et al. 2011

Pharmaceutical Biology

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“…6B, lane 6 versus lane 5), further supporting that KLF11 regulates MAO A gene expression through Sp/KLF-binding sites. Transfection of the GR increased dexamethasone-induced GRE-containing promoter activity 2.0-fold (Fig.…”

Section: Glucocorticoid Exposure Activates the Expression And Nuclearmentioning

confidence: 67%

“…Chronic stress increases the levels of blood glucocorticoids (1-3) and brain monoamine oxidase (MAO) 3 A (4,5). Monoamine oxidases (MAO) are catalytic enzymes prevalent in the brain and peripheral tissue (6).…”

mentioning

confidence: 99%

Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression

Grunewald

Johnson

et al. 2012

Journal of Biological Chemistry

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Background:The function of KLF11/TIEG2 under stressful conditions is undefined. Results: KLF11 increases brain MAO expression through its promoter and a chromatin partner, which can be enhanced by stress. Conclusion: This is the first elucidation of mechanisms underlying stress-induced KLF11-MAO up-regulation. Significance: This novel KLF11-MAO pathway may play an important role in stress-related brain disorders.

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Peoniflorin prevents the adhesion between inflammatory endothelial cells and leukocytes through inhibiting the activation of MAPKs and NF‐κB

Gao

Song

et al. 2010

Drug Development Research

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The vascular endothelium can be activated by multiple factors, including lipopolysaccharide (LPS) functioning as a key component of the inflammatory response. Activated endothelium promotes the recruitment of leukocytes mainly by releasing various adhesion molecules and amplifies inflammation via a feedback loop. Peoniflorin, the main active constituent of the roots of Paeonia lactiora Pall., possesses anti-inammatory, anti-infective, and anti-platelet aggregative properties. To elucidate the anti-inammatory mechanism of peoniflorin, the present study was conducted to address its effects on the adhesion of inflammatory endothelial cells to leukocytes. Peoniflorin substantially reduced adhesion of either human acute monocytic leukemia cells (THP-1) or human acute promyelocytic leukemia cells (HL-60) to LPS-stimulated human umbilical vein endothelial cells (HUVECs). It also markedly down-regulated the expression of E-selectin at both the gene and protein levels. However, peoniflorin only slightly reduced expression of intercellular adhesion molecule-1 (ICAM-1). Signal pathway analysis indicated that peoniflorin reduced phosphorylation of c-Jun NH 2 -terminal kinase (JNK) and p38 kinase, as well as the phosphorylation and degradation of IkB-a in HUVECs. These findings suggest that prevention of the adhesion between inflammatory endothelial cells and leukocytes contributes, at least partially, to the anti-inflammation action of peoniflorin. The anti-adhesion Abbreviations used: LPS, lipopolysaccharide; GPL, glycosides isolated from the roots of Paeonia lactiora Pall.; HUVECs, human umbilical vein endothelial cells; HL-60, human acute promyelocytic leukemia cell line; THP-1, human acute monocytic leukemia cell line; MAPK, mitogen-activated protein kinase; JNK, c-Jun NH 2 -terminal kinase; ERK, extracellular signal-regulated kinase; NF-kB, nuclear factor-kappa B; ICAM-1, intercellular adhesion molecule-1; BCECF-AM, Bis-carboxyethyl-carboxyfluorescein acetoxy-methyl; DEX, dexamethasone; NBCS, newborn calf serum; TLR4, toll-like receptor 4; MD2, myeloid differentiation protein-2; IkB, inhibitor of kB.c 2010 Wiley-Liss, Inc.mechanisms of peoniflorin were involved in the down-regulation of the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kB), and a reduction of adhesion molecule expressions in endothelial cells. Drug Dev Res 71: 275-284, 2010.

show abstract

Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity

Cited by 53 publications

References 33 publications

Anti-depressant-like effect of peony: a mini-review

Anti-depressant-like effect of peony: a mini-review

Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression

Peoniflorin prevents the adhesion between inflammatory endothelial cells and leukocytes through inhibiting the activation of MAPKs and NF‐κB

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