Effects of pentagastrin, histamine, carbamylcholine and catecholamines on gastric secretion, motility and emptying in the rat

Tani, Shigemasa; Muto, Norio

doi:10.1016/0006-2952(82)90629-3

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…Acetylcholine contracts the stomach in rats, rabbits, dogs, and humans 20 . The cholinergic agonist carbachol contracts gastric smooth muscle in rats and mice 21,22 . In this study, carbachol decreased intragastric volume.…”

Section: Discussionsupporting

confidence: 51%

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Central vagal stimulation evokes gastric volume changes in mice: a novel technique using a miniaturized barostat

Monroe

Hornby

Partosoedarso

2004

Neurogastroenterology Motil

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We have developed a novel technique to measure gastric volume in vivo in mice; this will be invaluable for revealing gastric alterations in genetically modified mice models, thus expanding our understanding of the mechanisms underlying functional disorders. Experimental data on gastric tone currently available has focused on rats using isovolumetric techniques to measure pressure changes, whereas clinical studies use barostatic techniques to measure volume changes. For better translational approaches, we assessed the feasibility of using a miniaturized barostat to measure gastric volume changes in urethane-anaesthetized and unanaesthetized-decerebrate mice. Additionally, we assessed whether central vagal stimulation alters gastric volume in urethane-anaesthetized mice. Nitric oxide donor sodium nitroprusside (1mg kg-1 i.p.) increased gastric volume (+134 +/- 20 microL), whereas the cholinergic agonist carbachol (3 microg kg-1 i.p.) decreased gastric volume (-153 +/- 20 microL). Similar responses were obtained in urethane-anaesthetized and unanaesthetized-decerebrate animals. Microinjection of L-glutamate (25 nmol) into dorsal motor nucleus of the vagus (DMV) altered gastric volume; microinjection into rostral DMV led to gastric contraction (-83 +/- 18 microL) while stimulation of caudal DMV resulted in gastric relaxation (+95 +/- 16 microL). This reveals a functional organization of DMV in mice. This study validates barostatic techniques for application to mice. An understanding of gastric contractility and tone is clinically relevant as impaired gastric accommodation reflex may be an underlying cause of functional dyspepsia.

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Section: Discussionsupporting

confidence: 51%

“…20 The cholinergic agonist carbachol contracts gastric smooth muscle in rats and mice. 21,22 In this study, carbachol decreased intragastric volume. Thus, the small but significant changes in gastric volume evoked by systemic agents demonstrate that the method is valid for use in the mice.…”

Section: Discussionsupporting

confidence: 46%

Central vagal stimulation evokes gastric volume changes in mice: a novel technique using a miniaturized barostat

Monroe

Hornby

Partosoedarso

2004

Neurogastroenterology Motil

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“…These results partly agree with the classical idea that HI-receptors induce contraction and Hzreceptors relaxation of smooth muscle; however, with inhibition also being antagonized by chlorpheniramine, it is likely that histamine causes contraction by acting on HI-receptors and relaxation by acting at both HI-and Hz-receptors. These results are in agreement with studies performed in in-vivo models refering to gastric motility of anaesthetized rats (Tani & Muto 1982); but they disagree with other results with invitro preparations of guinea-pig ileum showing that stimulation of histamine H2-receptors mediates the release of contractile agents (Barker & Ebersole 1982) and may potentiate the contractile response to acetylcholine (Zavecz & Yellin 1982). However, the motor effects induced by histamine do not seem to be secondary to a stimulated gastric acid secretion since cirnetidine fails to antagonize these effects.…”

Section: Discussionsupporting

confidence: 76%

Involvement of Different Receptors in the Central and Peripheral Effects of Histamine on Intestinal Motility in the Rat

Fargeas¹,

Fioramonti²,

Buéno³

1989

Journal of Pharmacy and Pharmacology

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The effects of histamine on intestinal motility have been investigated in conscious rats, fed or fasted, using an electromyographic method. Histamine peripherally administered (10 mg kg-1) in 15 h fasted rats induced an inhibition followed by a period of irregular spiking activity disrupting the duodenojejunal migrating myoelectric complexes (MMC) and suppressed the postprandial motor spiking activity when administered 50 min after a meal. The selective agonist of the H1-receptors, 2-pyridylethylamine (2-PEA) induced an irregular spiking activity while dimaprit acting on H2-receptors, inhibited the MMC pattern. Effects of peripherally administered histamine were antagonized by previous administration of chlorpheniramine (0.5 mg kg-1 i.p.) and in a lesser extent by cimetidine (10 mg kg-1 i.p.). Histamine (1-10 micrograms) administered intracerebroventricularly (i.c.v.) in fasted rats increased the motor cycle frequency and immediately restored the MMC pattern when given to fed rats. Among the three agonists of the H1- H2- and H3-receptors (2-PEA, dimaprit and R-alpha-methylhistamine, respectively) only R-alpha-methylhistamine (1-10 micrograms i.c.v.) was able to reproduce this effect. It is concluded that the effects of histamine on intestinal motility were centrally and peripherally mediated involving mainly H1-receptors at the peripheral level and H3-receptors at the CNS level.

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“…It is well-known that peripherally administered nicotine enhances the release of catecholamines from adrenal glands and sympathetic nerve terminals. Both the catecholamines released from adrenal glands and those released via activation of the sympathetic nerve are associated with the inhibition of gastric motility (3)(4)(5)(6)(7). Nicotine has both stimulatory and inhibitory actions on autonomic ganglia.…”

Section: Abstract-effectsmentioning

confidence: 99%

Central inhibition of gastric motility by intravenously administered nicotine in rats.

Nagata¹,

Osumi²

1990

Jpn.J.Pharmacol

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Abstract-Effects of intravenously (i.v.) administered nicotine on gastric motility were investigated in urethane-anesthetized rats in which an intragastric balloon had been placed.I.v. administered nicotine at 75-300 nmole/kg dose-dependently decreased gastric motility.Decrease in gastric motility induced by nicotine at the dose of 300 nmole/kg was inhibited by intracisternally administered hexamethonium. Gastric motility was also decreased by intracisternally applied nicotine (1-10 nmole). These doses were much smaller than those by the intracerebroventricular route in our previous report.

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Effects of pentagastrin, histamine, carbamylcholine and catecholamines on gastric secretion, motility and emptying in the rat

Cited by 11 publications

References 22 publications

Central vagal stimulation evokes gastric volume changes in mice: a novel technique using a miniaturized barostat

Central vagal stimulation evokes gastric volume changes in mice: a novel technique using a miniaturized barostat

Involvement of Different Receptors in the Central and Peripheral Effects of Histamine on Intestinal Motility in the Rat

Central inhibition of gastric motility by intravenously administered nicotine in rats.

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