Effects of pentachlorophenol on hepatic drug-metabolizing enzymes and porphyria related to contamination with chlorinated dibenzo-p-dioxins and dibenzofurans

Goldstein, Joyce A.; Friesen, Marlin D.; Linder, Ralph E.; Hickman, Patricia; Hass, J. Ronald; Bergman, Hinda

doi:10.1016/0006-2952(77)90068-5

Cited by 105 publications

(25 citation statements)

References 33 publications

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“…The remaining otters with TCDD and TCDF above 1 ng kg −1 were usually located along the coast and away from industry, suggesting non-point sources. Some otters with higher concentrations of total H6CDD, total H7CDD and OCDD may have been exposed to PCP, a wood preservative from which higher chlorinated PCDDs and PCDFs are present as impurities (Schwetz et al 1974;Goldstein et al 1977;Elliott et al 1999). Elliott et al (1998) also reported a significant relationship between PCP and OCDD in osprey eggs from an area of heavy chlorophenolic use.…”

Section: Pcbsmentioning

confidence: 95%

Environmental contaminants in male river otters from Oregon and Washington, USA, 1994–1999

Grove

Henny

2007

Environ Monit Assess

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This study reports hepatic concentrations and distribution patterns of select metals, organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in 180 male river otters (Lontra canadensis) collected from Oregon and Washington, 1994-1999. Seven regional locations of western Oregon and Washington were delineated based on associations with major population centers, industry or agriculture. Cadmium (Cd) was not found above 0.5 microg g(-1), dry weight (dw) in juveniles, but increased with age in adults though concentrations were generally low (nd-1.18 microg g(-1), dw). Regional geometric means for total mercury (THg) ranged from 3.63 to 8.05 microg g(-1), dw in juveniles and 3.46-12.6 microg g(-1) (dw) in adults. The highest THg concentration was 148 microg g(-1), dw from an apparently healthy adult male from the Olympic Peninsula of Washington. Although THg increased with age in adult otters, the occurrence of the more toxic form methylmercury (MeHg) was not evaluated. Mean OC and PCB concentrations reported in this study declined dramatically from those reported in 1978-1979 from the lower Columbia River. Organochlorine pesticide and metabolite means for both juvenile and adult river otter males were all below 100 microg kg(-1), wet weight (ww), with only DDE, DDD and HCB having individual concentrations exceeding 500 microg kg(-1), ww. Mean SigmaPCB concentrations in both juvenile and adult male otters were below 1 microg g(-1) for all regional locations. Mean juvenile and adult concentrations of non-ortho substituted PCBs, PCDDs and PCDFs were in the low ng kg(-1) for all locations studied.

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Section: Pcbsmentioning

confidence: 95%

Environmental contaminants in male river otters from Oregon and Washington, USA, 1994–1999

Grove

Henny

2007

Environ Monit Assess

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“…In contrast, several studies comparing technical-grade with purified PCP showed the former to produce chloracne, significant liver damage, and altered biochemistry consistent with the presence of dibenzodioxins and dibenzofurans (Table 1.2) (8,9). Some (but not all) of these "neutral impurities" are extremely toxic, the most potent effects presently being associated with chlorination at the 2, 3, 7, and 8 positions (Table 1.3).…”

Section: Toxicity and Hazardmentioning

confidence: 99%

Environmental chemistry of pentachlorophenol

Crosby¹

1981

Pure and Applied Chemistry

322

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“…Subchronic health effects in laboratory animals administered PCP are an increase in liver and kidney weights (Johnson et ai. 1973), a decrease in body weight (Deichmann et al 1942, Goldstein et al 1977. and the development of liver and splenic tumors (Kerkvliet et al 1982a,b).…”

Section: Quantitative Description Of Health Effectsmentioning

confidence: 99%

Preliminary Risk Assessment for Eight Selected Study Areas. Volume II

ABINGDON¹

1996

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Effects of pentachlorophenol on hepatic drug-metabolizing enzymes and porphyria related to contamination with chlorinated dibenzo-p-dioxins and dibenzofurans

Cited by 105 publications

References 33 publications

Environmental contaminants in male river otters from Oregon and Washington, USA, 1994–1999

Environmental contaminants in male river otters from Oregon and Washington, USA, 1994–1999

Environmental chemistry of pentachlorophenol

Preliminary Risk Assessment for Eight Selected Study Areas. Volume II

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