Effects of pectin structure and crosslinking method on the properties of crosslinked pectin nanofibers

Cui, Sisi; Yao, Bing; Gao, Meijiao; Sun, Xiaofeng; Gou, Dongxia; Hu, Junli; Zhou, Yifa; Liu, Yichun

doi:10.1016/j.carbpol.2016.10.052

Cited by 91 publications

(38 citation statements)

References 29 publications

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“…Some of these lead to hydrolysis and deamidation of peptide bonds. The control pectin hydrogel (PH) also exhibited mass loss of only around 40% at temperatures between 150 and 300 °C, which is similar to that found by Cui et al, 22 while the loaded PH presented two mass losses, one at around 8% (150 to 188 °C) and the other at 29% (190 to 300 °C) (Figure 1c). Thence, the loaded pectin hydrogel presented the greatest thermal stability.…”

Section: Hydrogels Characterizationsupporting

confidence: 84%

Preparation and Delayed Release Study on Pancreatin Encapsulated into Alginate, Carrageenan and Pectin Hydrogels

Olímpio

Mendes

Trevisan

et al. 2020

J. Braz. Chem. Soc.

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In this study, biopolymer-based pH-sensitive hydrogels have been successfully prepared using alginate, κ-carrageenan and pectin aimed at the encapsulation of pancreatin (hydrolytic enzymes like α-amylase, lipase and protease) so as to preserve enzymatic activities. Hydrogels have been characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), swelling degree and swelling profile. Encapsulation efficiency and in vitro studies on delayed release have also been evaluated. All hydrogels presented low swelling degree and enzyme release in a gastric medium. On the other hand, high swelling degree and enzyme release were observed in an intestinal medium. Alginate hydrogel achieved optimal results concerning encapsulation efficiency (18, 68 and 53% for α-amylase, lipase and protease, respectively) and delayed release (363, 7,673 and 17,497 U for α-amylase, lipase and protease, respectively) which has been afterwards compared to a commercial pancreatin formulation (Creon TM 10,000). Thus, it presented better performance than its commercial formulation, mainly in respect of lipase.

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Section: Hydrogels Characterizationsupporting

confidence: 84%

Preparation and Delayed Release Study on Pancreatin Encapsulated into Alginate, Carrageenan and Pectin Hydrogels

Olímpio

Mendes

Trevisan

et al. 2020

J. Braz. Chem. Soc.

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“…The elastic modulus (G') of pectin may be finely tuned through adjustments in polymer and/or crosslinker concentration, thus allowing for the biomechanical mimicry of a broad range of native human tissue types. Ionic crosslinking with CaCl 2 also results in a substantial increase in yield stress (τ y) and therefore significantly augments the extrudability of the hydrogel and shape fidelity of the printed construct (Cui et al, 2017).…”

Section: Pectinmentioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

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“…Moreover, cross-linking of pectin molecules within the nanofibers is essential to increase their stability in aqueous solutions. Since pectin is composed of galacturonic acid with carboxyl groups, divalent cations, such as Ca 2+ , can be used as cross-linkers (Cui et al 2017). This is very similar to the polysaccharide alginate (Bonino et al 2011;Feng et al 2017).…”

Section: Introductionmentioning

confidence: 98%

“…When electrospinning pectin alone, forming nanofibers remains challenging. A synthetic polymer such as poly(ethylene oxide) (PEO) or poly(vinyl alcohol) (PVA) is blended in with the pectin to improve its ability to be electrospun into fibers ( , Cui et al 2017). Moreover, cross-linking of pectin molecules within the nanofibers is essential to increase their stability in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning pectin-based nanofibers: a parametric and cross-linker study

et al. 2018

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Pectin, a natural biopolymer mainly derived from citrus fruits and apple peels, shows excellent biodegradable and biocompatible properties. This study investigated the electrospinning of pectin-based nanofibers. The parameters, pectin:PEO (polyethylene oxide) ratio, surfactant concentration, voltage, and flow rate, were studied to optimize the electrospinning process for generating the pectin-based nanofibers. Oligochitosan, as a novel and nonionic cross-liker of pectin, was also researched. Nanofibers were characterized by using AFM, SEM, and FTIR spectroscopy. The results showed that oligochitosan was preferred over Ca 2+ because it cross-linked pectin molecules without negatively affecting the nanofiber morphology. Moreover, oligochitosan treatment produced a positive surface charge of nanofibers, determined by zeta potential measurement, which is desired for tissue engineering applications.

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Effects of pectin structure and crosslinking method on the properties of crosslinked pectin nanofibers

Cited by 91 publications

References 29 publications

Preparation and Delayed Release Study on Pancreatin Encapsulated into Alginate, Carrageenan and Pectin Hydrogels

Preparation and Delayed Release Study on Pancreatin Encapsulated into Alginate, Carrageenan and Pectin Hydrogels

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Electrospinning pectin-based nanofibers: a parametric and cross-linker study

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