Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact

Ventura, Sandra; Rodrigues, Márcio; Falcão, Amı́lcar; Alves, Gilberto

doi:10.1016/j.fct.2018.03.011

Cited by 20 publications

(12 citation statements)

References 35 publications

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“…First, Rodrigues et al [13] described that a significant reduction in the peak plasma concentration (73.2%) and in the extent of systemic exposure (57.8%) to amiodarone was found in rats simultaneously treated with guaraná. Latter, Ventura et al [14] found that the co-administration of P. cupana and lamotrigine resulted in a significant reduction of Cmax and AUC0-24 and prolonged the mean residence time of the antiepileptic agent. The same authors also stated that no significant effects were observed on lamotrigine pharmacokinetics following a 14-day pre-treatment period with the extract.…”

Section: Resultsmentioning

confidence: 99%

“…Briefly, 200 g of the powder was added to 1000 mL of distilled water and immersed for 20 min at room temperature, yielding a 20% (w/v) extract. A fresh preparation was used to administer to the animals using the dose protocol reported by Rodrigues et al [13] and Ventura et al [14]. The plant name Paullinia cupana Kunth has been checked with http://www.theplantlist.org and the levels of TPH and caffeine in the plant material assessed by HPLC were 1.9 and 20.0%, respectively.…”

Section: Preparation Of P Cupana Extractmentioning

confidence: 99%

“…Therefore, the possibility of herbal drug interactions prompted by guaraná was highlighted recently [12]. In this context, the effect of P. cupana on the kinetic disposition of amiodarone and lamotrigine was reported in rats [13,14]. Therefore, the aim of this research was to investigate the effects of the aqueous extract of P. cupana on the pharmacokinetics of theophylline, a drug with low therapeutic index, in rats.…”

Section: Introductionmentioning

confidence: 99%

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Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

Batista

Lima

Corrêa

et al. 2021

EJMP

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Aims: Paullinia cupana Kunth has been popularly used to prepare different beverages by the Amazonian inhabitants for a long time ago mainly due to its stimulant properties. Although the utilization of this herbal drug has been increasing lately, little is known regarding the possibility of drug interactions. Therefore, this research tried to investigate the effects of the aqueous extract of P. cupana on the pharmacokinetics of theophylline (TPH), a CYP1A marker in rats. Methodology: The extract was prepared according to the popular recipe and subjects received different once daily doses of extract (vehicle, 82.1 mg/Kg and 821 mg/Kg) by oral gavage during two weeks. Non-compartimental analysis was carried out to obtain the pharmacokinetic parameters. Results: Animals treated with P. cupana (AUC: 1,197.2 ± 284.4 and 346.6 ± 37.0 µg.h/mL for 82.1 and 821 mg/Kg, respectively) had lower exposition to TPH than controls (3,539.48 ± 278.4 µg.h/mL). On the other hand, drug clearance was higher in treated subjects (2.44 ± 0.4 and 7.27 ± 0.7 L/h/kg for 82.1 and 821 mg/Kg, respectively) than controls (0.71 ± 0.0 L/h/kg). Conclusion: Therefore, the multiple oral administration of an aqueous extract of P. cupana caused a significant effect on the pharmacokinetics of TPH in rats.

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Section: Resultsmentioning

confidence: 99%

Section: Preparation Of P Cupana Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

Batista

Lima

Corrêa

et al. 2021

EJMP

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“…Guarana flavanols-the main chemical component in guarana seeds aside from caffeine-have been seldom investigated regarding their involvement in pharmacokinetics and pharmacodynamic interactions. Ventura et al (2018) reported that the concurrent administration of lamotrigine (10 mg/kg), an antiepileptic drug, and guarana (821 mg/kg) negatively affected the rate of drug systemic exposure in rats. Therefore, pharmacological and toxicological studies are necessary to determine safe dosages and modes of administration.…”

Section: Toxicitymentioning

confidence: 99%

“…Ventura et al. (2018) reported that the concurrent administration of lamotrigine (10 mg/kg), an antiepileptic drug, and guarana (821 mg/kg) negatively affected the rate of drug systemic exposure in rats. Therefore, pharmacological and toxicological studies are necessary to determine safe dosages and modes of administration.…”

Section: Effects On Human Healthmentioning

confidence: 99%

Effects of the consumption of guarana on human health: A narrative review

Torres

Pinaffi-Langley

Figueira

et al. 2021

Comp Rev Food Sci Food Safe

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Guarana (Paullinia cupana) is a plant from the Amazon region with cultural importance. Despite its early ancestral use by indigenous tribes, the first reports regarding the benefits of guarana consumption for human health were published in the 19th century. Since then, the use of guarana seed in powder and extract forms has been studied for its diverse effects on human health, such as stimulating, anti-inflammatory, antioxidant, anticancer, hypocholesterolemic, and antiobesity effects. These effects are attributed to the high content of bioactive compounds found in guarana seeds, especially methylxanthines and flavonoids. In fact, the Brazilian Food Supplement Law has officially acknowledged guarana as a source of bioactive compounds. The number and diversity of studies focused on guarana and human health are increasing; thus, organizing and describing the available evidence on guarana and its applications is necessary to provide a framework for future studies. In this narrative review, we have organized the available information regarding guarana and its potential effects on human health. Guarana produces unique fruits with great potential for human health applications. However, the available evidence lacks human studies and mechanistic investigations. Future studies should be designed considering its applicability to human health, including intake levels and toxicity studies.

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Herb‐drug interactions: A short review on central and peripheral nervous system drugs

Bernardo,

Valentão

2024

Phytotherapy Research

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Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb‐drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self‐limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb‐drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems. Our work draws upon a broad range of evidence, encompassing preclinical data, animal studies, and clinical case reports. We delve into the intricate pharmacodynamics and pharmacokinetics underpinning each interaction, elucidating the mechanisms through which these interactions occur. One pressing issue that emerges from this analysis is the need for updated guidelines and sustained pharmacovigilance efforts. The topic of herb‐drug interactions often escapes the attention of both consumers and healthcare professionals. To ensure patient safety and informed decision‐making, it is imperative that we address this knowledge gap and establish a framework for continued monitoring and education. In conclusion, the use of herbal remedies alongside conventional medications is a practice replete with potential hazards. This review not only underscores the real and significant risks associated with herb‐drug interactions but also underscores the necessity for greater awareness, research, and vigilant oversight in this often‐overlooked domain of healthcare.

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Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact

Cited by 20 publications

References 35 publications

Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

Effects of the consumption of guarana on human health: A narrative review

Herb‐drug interactions: A short review on central and peripheral nervous system drugs

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