Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study

Lin, Jing; Gu, Wei; Huang, He‐Feng

doi:10.3389/fendo.2022.826665

Cited by 20 publications

(21 citation statements)

References 79 publications

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“…In this study, we found that paternal obesity before pregnancy was significantly related to an increased risk of macrosomia in babies and pregnancy complications in mothers, including HDCP, cesarean delivery, and GWG over guidelines. It is similar to the results of Lin J et al (28). Moreover, the incidences of SGA in offspring were significantly higher in the underweight paternal groups.…”

Section: Discussionsupporting

confidence: 91%

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

et al. 2023

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ObjectiveThis study evaluated whether paternal body mass index (BMI) before pregnancy was a risk factor for maternal-neonatal outcomes and long-term prognosis in offspring.MethodsThis study included 29,518 participants from eight cities in Fujian, China using a stratified cluster random sampling method from May to September 2019. They were divided into four groups based on paternal BMI. Univariate and multivariate logistic regression were used to explore the relationship between paternal BMI groups, maternal-neonatal outcomes, and long-term prognosis in offspring. Further subgroup analysis was conducted to examine the stability of the risk. ResultsThe incidences of hypertensive disorder complicating pregnancy (HDCP), cesarean delivery, gestational weight gain (GWG) over guideline, and macrosomia were significantly higher in the paternal overweight and obesity group. Importantly, this study demonstrated that the incidence of asthma, hand-foot-and-mouth disease (HFMD), anemia, dental caries, and obesity of adolescents in paternal obesity increased. Furthermore, logistic regression and subgroup analysis confirm paternal obesity is a risk factor for HDCP, cesarean delivery, and macrosomia. It caused poor long-term prognosis in adolescents, including asthma, dental caries, and HFMD.ConclusionsPaternal obesity is a risk factor for adverse maternal-neonatal outcomes and poor long-term prognosis in adolescents. In addition to focusing on maternal weight, expectant fathers should pay more attention to weight management since BMI is a modifiable risk factor. Preventing paternal obesity can lead to better maternal and child outcomes. It would provide new opportunities for chronic diseases.

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Section: Discussionsupporting

confidence: 91%

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

et al. 2023

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“…Placentas derived from obese sires, like hypoxic placentas, exhibit changes in gene expression and altered angiogenesis, vasculature, and development (Binder et al, 2015, 2012; Jazwiec et al, 2022; Lin et al, 2022; McPherson et al, 2015; Mitchell et al, 2017). Hypoxia is a tightly regulated process during placental development which is essential for proper vascular formation.…”

Section: Resultsmentioning

confidence: 99%

“…In human studies, recurrent pregnancy loss is associated with increased seminal reactive oxygen species (ROS) and sperm DNA damage (Jayasena et al, 2019). Male partner metabolic syndrome and being overweight have been associated with an increased risk for pre-eclampsia and negative pregnancy outcomes (Lin, Gu, & Huang, 2022; Murugappan et al, 2021). Animal models suggest that pregnancy complications that have been associated with paternal metabolic complications may be a consequence of placental dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition

Pépin

Jazwiec

Dumeaux

et al. 2022

Preprint

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Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally driven gene expression in placenta function. To address this, we investigated paternal high-fat diet-induced obesity in relation to sperm epigenetic signatures, the placenta transcriptome and cellular composition. C57BL6/J males were fed either a control or high-fat diet for 10 weeks beginning at 6 weeks of age. Males were timed-mated with control-fed C57BL6/J females to generate pregnancies, followed by collection of sperm, and placentas at embryonic day (E)14.5. Chromatin immunoprecipitation targeting histone H3 lysine 4 tri-methylation (H3K4me3) followed by sequencing (ChIP-seq) was performed on sperm to define obesity-associated changes in enrichment. Paternal obesity corresponded with altered sperm H3K4me3 enrichment at imprinted genes, and at promoters of genes involved in metabolism and development. Notably, sperm altered H3K4me3 was localized at placental enhancers and genes implicated in placental development and function. Bulk RNA-sequencing on placentas detected paternal obesity-induced sex-specific changes in gene expression associated with hypoxic processes such as angiogenesis, nutrient transport and imprinted genes. Paternal obesity was also linked to placenta development; specifically, a deconvolution analysis revealed altered trophoblast cell lineage specification. These findings implicate paternal obesity-effects on placenta development and function as one mechanism underlying offspring metabolic disease.

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“…Despite this recommendation, almost 50% of women who were preparing for pregnancy were not taking folic acid, indicating a lack of understanding of the importance of preconception folic acid. Additionally, one of the main reasons given for why partners were not preparing was "We didn't know that they should be doing anything" suggesting that people are unaware of the impact that preconception paternal health can have (4,10,11).…”

Section: Discussionmentioning

confidence: 99%

“…Almost 50% of women in the UK are either overweight (BMI >25 kg/m 2) or obese (BMI >30 kg/m 2 ) when they become pregnant (1,6) which is associated with substantial risks for both mother and child, including sub-fertility, pregnancy complications, congenital fetal malformations and stillbirth (1,(7)(8)(9). However, it is not just maternal obesity that is an issue; paternal obesity has also been linked to impaired fertility, increased risk of adverse pregnancy outcomes and chronic disease risk in offspring (1,10,11). Despite the prevalence of overweight and obesity, micronutrient deficiencies continue to be a growing issue globally; studies have shown that many women of reproductive age will have dietary intakes below the recommend reference nutrient intake (RNI) for many micronutrients (1).…”

Section: Introductionmentioning

confidence: 99%

Pregnancy preparation amongst women and their partners in the UK; how common is it and what do people do?

Stewart

Hall

2022

Preprint

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Background Pregnancy preparation, to establish a healthy lifestyle within the preconception period, has been shown to reduce adverse maternal and neonatal outcomes. Despite its importance, we know very little about if and how people prepare for pregnancy in the UK. Methods As part of the P3 study, women in the UK were invited to complete an online survey about pregnancy preferences, including the Desire to Avoid Pregnancy (DAP) Scale. 274 participants were currently trying, thinking, or maybe thinking about getting pregnant and were asked about pregnancy preparations. The changes that women, and their partners, made in preparation for pregnancy, reasons for not preparing, and associations with sociodemographics were investigated in univariate and multivariate analyses. Results Of the 274 women, less than half (n=134, 49%) reported making any changes in preparation for pregnancy, with the most common changes being ′eating healthier′ (55%) and ′folic acid′ (54%). The main reason for not preparing was ′only thinking about getting pregnant′ (38%). 92 women answered questions about partner preparations; only 24% of partners were preparing, with the most common changes being ′eating healthier′ (64%) and ′reducing alcohol′ (50%). The main reason for partners not preparing was ′already healthy′ (51%). DAP score was the only significant factor affecting pregnancy preparation; every one-point increase in DAP score reduced the odds of a woman preparing for pregnancy by 78% (OR 0.22, 95%CI 0.15-0.34). Conclusion Interventions addressing pregnancy preparation for women, and their partners, are needed. These strategies should target women thinking about pregnancy, to ensure the full benefits of preconception care are received.

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Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study

Cited by 20 publications

References 79 publications

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

Effects of paternal obesity on maternal-neonatal outcomes and long-term prognosis in adolescents

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition

Pregnancy preparation amongst women and their partners in the UK; how common is it and what do people do?

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