Effects of passive, moderate-level sound exposure on the mature auditory cortex: Spectral edges, spectrotemporal density, and real-world noise

Pienkowski, Martin; Munguia, Raymundo; Eggermont, Jos J.

doi:10.1016/j.heares.2012.11.006

Cited by 35 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The neural enhancement at the edge-frequencies of the spectral notch is reminiscent of the long-term central changes triggered by cochlear hearing loss, i.e., neural enhancement or even unmasking at the edge-frequency of hearing loss (Calford et al 1993;Noreña and Eggermont 2005;Robertson and Irvine 1989). In case of an extensive exposure (for a few weeks) to an acoustic environment with spectral notch, it can be speculated that the short-term changes reported in this study may be gradually converted into long-term changes (Noreña et al 2006;Pienkowski and Eggermont 2010;Pienkowski et al 2013). Our results further suggest that chronic exposure to an acoustic environment with a spectral contrast as small as 10 dB and presented at a moderate level (ϳ70 dB SPL) may be sufficient to produce chronic central changes.…”

Section: Discussionmentioning

confidence: 76%

Dynamic representation of spectral edges in guinea pig primary auditory cortex

Montejo

Noreña

2015

Journal of Neurophysiology

View full text Add to dashboard Cite

Montejo N, Noreña AJ. Dynamic representation of spectral edges in guinea pig primary auditory cortex. J Neurophysiol 113: 2998 -3012, 2015. First published March 5, 2015 doi:10.1152/jn.00785.2014.-The central representation of a given acoustic motif is thought to be strongly context dependent, i.e., to rely on the spectrotemporal past and present of the acoustic mixture in which it is embedded. The present study investigated the cortical representation of spectral edges (i.e., where stimulus energy changes abruptly over frequency) and its dependence on stimulus duration and depth of the spectral contrast in guinea pig. We devised a stimulus ensemble composed of random tone pips with or without an attenuated frequency band (AFB) of variable depth. Additionally, the multitone ensemble with AFB was interleaved with periods of silence or with multitone ensembles without AFB. We have shown that the representation of the frequencies near but outside the AFB is greatly enhanced, whereas the representation of frequencies near and inside the AFB is strongly suppressed. These cortical changes depend on the depth of the AFB: although they are maximal for the largest depth of the AFB, they are also statistically significant for depths as small as 10 dB. Finally, the cortical changes are quick, occurring within a few seconds of stimulus ensemble presentation with AFB, and are very labile, disappearing within a few seconds after the presentation without AFB. Overall, this study demonstrates that the representation of spectral edges is dynamically enhanced in the auditory centers. These central changes may have important functional implications, particularly in noisy environments where they could contribute to preserving the central representation of spectral edges.

show abstract

Section: Discussionmentioning

confidence: 76%

Dynamic representation of spectral edges in guinea pig primary auditory cortex

Montejo

Noreña

2015

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…These observations prompted a reconceptualization of developmental and adult plasticity as more accurately representing successive epochs of exposure-based and reinforcement-based plasticity, respectively [95, 96]. However, as the exception that ultimately proves the rule, Eggermont and colleagues have shown a surprising and profound tonotopic reorganization in adult cats passively exposed to moderate intensity acoustic stimuli that aggregate spectral energy into a restricted frequency band [97–102]. Though ostensibly at odds with findings that underscore the stability of the adult map, both sets of findings can be reconciled by a unified framework for topographic map plasticity founded on neurobiological mechanisms rather than teleological categories.…”

Section: Mechanisms Of Map Plasticitymentioning

confidence: 99%

Auditory map plasticity: diversity in causes and consequences

Schreiner

Polley

2014

Current Opinion in Neurobiology

View full text Add to dashboard Cite

Auditory cortical maps have been a long-standing focus of studies that assess the expression, mechanisms, and consequences of sensory plasticity. Here we discuss recent progress in understanding how auditory experience transforms spatially organized sound representations at higher levels of the central auditory pathways. New insights into the mechanisms underlying map changes have been achieved and more refined interpretations of various map plasticity effects and their consequences in terms of behavioral corollaries and learning as well as other cognitive aspects have been offered. The systematic organizational principles of cortical sound processing remains a key-aspect in studying and interpreting the role of plasticity in hearing.

show abstract

“…A large portion of these studies have been performed in cats (Eggermont and Komiya 2000, Pienkowski and Eggermont 2009, Pienkowski and Eggermont 2009, Pienkowski and Eggermont 2010, Pienkowski and Eggermont 2010, Pienkowski, Munguia et al 2011, Pienkowski and Eggermont 2012, Munguia, Pienkowski et al 2013, Pienkowski, Munguia et al 2013). Results from these studies indicate that sound-evoked local field potentials (LFPs), spike discharge rates (SDRs) and spontaneous firing rates in the primary auditory cortex (A1) become hypoactive to sound stimulation within the exposure frequency band (tone-pip ensembles, 68–72 dB SPL) and hyperactive to stimuli near the upper and lower edges of the exposure band (Pienkowski and Eggermont 2010, Pienkowski and Eggermont 2010, Munguia, Pienkowski et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Prolonged low-level noise-induced plasticity in the peripheral and central auditory system of rats

et al. 2017

View full text Add to dashboard Cite

Prolonged low-level noise exposure alters loudness perception in humans, presumably by decreasing the gain of the central auditory system. Here we test the central gain hypothesis by measuring the acute and chronic physiologic changes at the level of the cochlea and inferior colliculus (IC) after a 75 dB SPL, 10–20 kHz noise exposure for 5 weeks. The compound action potential (CAP) and summating potential (SP) were used to assess the functional status of the cochlea and 16 channel electrodes were used to measure the local field potentials (LFP) and multi-unit spike discharge rates (SDR) from the IC immediately after and one-week post-exposure. Measurements obtained immediately post-exposure demonstrated a significant reduction in supra-threshold CAP amplitudes. In contrast to the periphery, sound-evoked activity in the IC was enhanced in a frequency-dependent manner consistent with models of enhanced central gain. Surprisingly, one-week post-exposure supra-threshold responses from the cochlea had not only recovered, but were significantly larger than normal, and thresholds were significantly better than controls. Moreover, sound-evoked hyperactivity in the IC was sustained within the noise exposure frequency band but suppressed at higher frequencies. When response amplitudes representing the neural output of the cochlea and IC activity at one-week post exposure were compared with control animal responses, a central attenuation phenomenon becomes evident, which may play a key role in understanding why low-level noise can sometimes ameliorate tinnitus and hyperacusis percepts.

show abstract

Effects of passive, moderate-level sound exposure on the mature auditory cortex: Spectral edges, spectrotemporal density, and real-world noise

Cited by 35 publications

References 22 publications

Dynamic representation of spectral edges in guinea pig primary auditory cortex

Dynamic representation of spectral edges in guinea pig primary auditory cortex

Auditory map plasticity: diversity in causes and consequences

Prolonged low-level noise-induced plasticity in the peripheral and central auditory system of rats

Contact Info

Product

Resources

About