Effects of Particulate Matter and Antioxidant Dietary Intake on Blood Pressure

Schulz, Amy J.; Mentz, Graciela; Sampson, Natalie; Dvonch, J. Timothy; Reyes, Ángela; Izumi, Betty T.

doi:10.2105/ajph.2014.302176

Cited by 24 publications

(28 citation statements)

References 68 publications

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“…29, 30 One study from Detroit also reported that antioxidant intake may protect against cardiovascular effects of PM 2.5 . 31 Taken together, our study supported an intervention through increasing intake of fruit and vegetables to reduce the adverse effects of ambient PM 2.5 exposure.…”

Section: Discussionsupporting

confidence: 66%

Ambient PM _2.5 and Stroke

Lin

Guo

et al. 2017

Stroke

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Background and Purpose Short-term exposure to ambient fine particulate pollution (PM2.5) has been linked to increased stroke. Few studies, however, have examined the effects of long-term exposure. Methods A total of 45,625 participants were interviewed and included in this study, the participants came from the Study on Global AGEing and Adult Health, a prospective cohort in six low- and middle-income countries. Ambient PM2.5 levels were estimated for participants’ communities using satellite data. A multi-level logistic regression model was used to examine the association between long-term PM2.5 exposure and stroke. Potential effect modification by physical activity and consumption of fruit and vegetables was assessed. Results The odds of stroke were 1.13 (95% CI: 1.04, 1.22) for each 10 μg/m3 increase in PM2.5. This effect remained after adjustment for confounding factors including age, sex, smoking and indoor air pollution (adjusted OR=1.12, 95% CI: 1.04, 1.21). Further stratified analyses suggested that participants with higher levels of physical activity had greater odds of stroke, while those with higher consumption of fruit and vegetables had lower odds of stroke. These effects remained robust in sensitivity analyses. We further estimated that 6.55% (95% CI: 1.97%, 12.01%) of the stroke cases could be attributable to ambient PM2.5 in the study population. Conclusions This study suggests that ambient PM2.5 may increase the risk of stroke, and may be responsible for the astounding stroke burden in low- and middle-income countries. Additionally, greater physical activity may enhance, whereas greater consumption of fruit and vegetables may mitigate the effect.

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Section: Discussionsupporting

confidence: 66%

Ambient PM _2.5 and Stroke

Lin

Guo

et al. 2017

Stroke

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“…Results obtained in the current study generally provide evidence in support of the hypothesis that intake of micronutrients-rich diets may modify the adverse effects of PM 2.5 on BP as reported by Schulz et al (2015). For instance, in the joint effect model ( Supplementary Table 4), adequate Fe intake dampened the effects of exposure to higher levels of PM 2.5 on SBP after controlling for covariates in e-waste recyclers.…”

Section: Effects Of Dietary Micronutrient Intake On the Association Bsupporting

confidence: 86%

“…Several studies have reported the adverse effects of PM 2.5 on BP outcomes(Majkova et al, 2010;Nachvak et al, 2016;Schulz et al, 2015; Whyand et al, 2018), with few focusing on how intake of micronutrient-rich diets may ameliorate these effects. To the best of our knowledge, this study is the first-ever to examine the role of micronutrient-rich dietary intake in reducing the harmful effects of PM among e-waste recyclers.…”

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confidence: 99%

Micronutrient-rich dietary intake is associated with a reduction in the effects of particulate matter on blood pressure among electronic waste recyclers at Agbogbloshie, Ghana

Takyi

Basu

Arko‐Mensah

et al. 2020

Preprint

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Background: Informal recycling of electronic waste (e-waste) releases particulate matter (PM) into the ambient air. Human exposure to PM has been reported to induce adverse effects on cardiovascular health. However, the impact of PM on the cardiovascular health of e-waste recyclers in Ghana has not been studied. Although intake of micronutrient-rich diet is known to modify these PM-induced adverse health effects, no data are available on the relationship between micronutrient status of e-waste recyclers and the reported high-level exposure to PM.Objectives: We investigated whether intake of micronutrient-rich diets ameliorates the adverse effects of ambient exposure to PM2.5 on blood pressure (BP).Methods: This study was conducted from March 2017 to October 2018; involving the measurement of breathing zone PM2.5 using real-time monitor. Dietary micronutrient (Fe, Ca, Mg, Se, Zn, and Cu) intake was assessed using a 2-day 24-hour recall, whiles cardiovascular indices such as systolic BP (SBP) and diastolic BP (DBP) and pulse pressure (PP) were measured using a sphygmomanometer. Ordinary least-squares regression models were used to estimate the joint effects of ambient exposure to PM2.5 and dietary micronutrient intake on cardiovascular health outcomes. The results: Fe was consumed in adequate quantities. However, Ca, Se, Zn, Mg, and Cu were inadequately consumed among e-waste recyclers and controls. Dietary Ca and Fe intake were associated with reduced SBP and PP of e-waste recyclers. Although PM2.5 levels were higher in e-waste recyclers, the controls exceeded the WHO 24-hour guideline value (25µg/m3). Exposure to 1µg/m3 of PM2.5 was associated with increased HR of e-waste recyclers by 0.06 bpm; implying informal recycling of e-waste may be a risk factor for tachycardia. Also, dietary Fe intake was associated with a reduction in systolic blood pressure levels of e-waste recyclers.Conclusions: Consistent adequate dietary Fe intake was associated with reduced effects of PM2.5 on SBP of e-waste recyclers overtime. However, as all other micronutrients are essential in ameliorating adverse effects of PM on cardiovascular health, nutrition-related policy dialogues are necessary to educate informal e-waste recyclers and the general population on specific nutrients of concern and their impact on the exposure to ambient air pollutants.

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“…One study from Detroit also reported that dietary antioxidant intake may protect against the adverse cardiovascular effects of ambient PM 2.5 . 41 A cohort study in Mexico reported that a high intake of fruit could modulate the adverse effect of O 3 on lung function among children. 42 Studies from Spain and Denmark also suggested that intake of fruit was associated with decreased mental health effects of air pollution.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Ambient PM _2.5 on Hypertension and Blood Pressure and Attributable Risk Among Older Chinese Adults

et al. 2017

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Long-term exposure to ambient fine particulate pollution (PM2.5) has been associated with cardiovascular diseases. Hypertension, a major risk factor for cardiovascular diseases, has also been hypothesized to be linked to PM2.5. However, epidemiological evidence has been mixed. We examined long-term association between ambient PM2.5 and hypertension and blood pressure. We interviewed 12,665 participants aged 50 years and older and measured their blood pressures. Annual average PM2.5 concentrations were estimated for each community using satellite data. We applied two-level logistic regression models to examine the associations, and estimated hypertension burden attributable to ambient PM2.5. For each 10 μg/m3 increase in ambient PM2.5, the adjusted odds ratio of hypertension was 1.14 (95% confidence interval, 1.07, 1.22). Stratified analyses found that overweight and obesity could enhance the association, and consumption of fruit was associated with lower risk. We further estimated that 11.75% (95% confidence interval: 5.82%, 18.53%) of the hypertension cases (corresponding to 914, 95% confidence interval: 453, 1442 cases) could be attributable to ambient PM2.5 in the study population. Findings suggest that long-term exposure to ambient PM2.5 might be an important risk factor of hypertension, and is responsible for significant hypertension burden in adults in China. A higher consumption of fruit may mitigate, while overweight and obesity could enhance this effect.

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Effects of Particulate Matter and Antioxidant Dietary Intake on Blood Pressure

Cited by 24 publications

References 68 publications

Ambient PM _2.5 and Stroke

Ambient PM _2.5 and Stroke

Micronutrient-rich dietary intake is associated with a reduction in the effects of particulate matter on blood pressure among electronic waste recyclers at Agbogbloshie, Ghana

Long-Term Effects of Ambient PM _2.5 on Hypertension and Blood Pressure and Attributable Risk Among Older Chinese Adults

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Effects of Particulate Matter and Antioxidant Dietary Intake on Blood Pressure

Cited by 24 publications

References 68 publications

Ambient PM 2.5 and Stroke

Ambient PM 2.5 and Stroke

Micronutrient-rich dietary intake is associated with a reduction in the effects of particulate matter on blood pressure among electronic waste recyclers at Agbogbloshie, Ghana

Long-Term Effects of Ambient PM 2.5 on Hypertension and Blood Pressure and Attributable Risk Among Older Chinese Adults

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Ambient PM _2.5 and Stroke

Ambient PM _2.5 and Stroke

Long-Term Effects of Ambient PM _2.5 on Hypertension and Blood Pressure and Attributable Risk Among Older Chinese Adults