Three groups of 12 rats received 25 pretraining trials to each future discriminandum employed in a subsequent differential brightness conditioning problem. Groups NR and RN received partial reinforcement (PRF) pretraining either with or without, respectively, transitions from nonrewarded to rewarded trials (N-R transitions). Group CRF received consistent reinforcement during pretraining. A fourth group (n=12), Group NP, received no pretraining. During discrimination learning, one-half of the rats in each group received all their daily S+ trials preceding their daily S-trials (+-sequence); the remainder of the rats received an intermixed sequence of trials to S+ and S-(+-+ sequence). Discrimination learning was faster under the +-sequence than under the +-+ condition, and discrimination learning was retarded in Group NR relative to the other three groups, which did not differ from one another, under both the +-and +-+ discrimination sequence conditions. The results are discussed with reference to previous experiments demonstrating N-R transition effects on discrimination learning, a theoretical extension of sequential theory to discrimination learning, and the effects of nondifferential reinforcement prior to discrimination learning on learned irrelevance.Discrimination learning is retarded in groups given an intermixed sequence of trials to the positive (S+ ) and negative (S-) stimuli, which contains transitions from nonrewarded trials in S-to rewarded trials in S+ (N-R transitions), relative to groups given all of their daily S+ trials preceding their daily S-trials (Haggbloom, 1978;Haggbloom & Tillman, 1980). Partial reinforcement (PRF) administered within S+ also retards discrimination learning, but only if the S+ PRF schedule containsN-Rtransitions (Haggbloom, 1980a(Haggbloom, , 1980b(Haggbloom, , 1980c(Haggbloom, , 1981b McHose & Blackwell, (197S). These effects of N-R transitions on discrimination learning are due primarily to retarded extinction of responding to S-, a behavior termed resistance to discrimination (Haggbloom, 1980b).The effect of N-R transitions on resistance to discrimination parallels the effect of that variable on resistance to extinction following conventional PRF (e.g., Capaldi, 1966). And both effects appear to be due to the behavioral control acquired by SN, the memory of nonreward. In discrimination learning, SN enters into a stimulus compound with the nominally relevant discriminanda (e.g., brightness cues) and can control behavior in a way that either interferes with or complements the control exercised by