Effects of partial cuts on gastric electrical control activity and its computer model

Sarna, S. K.; Daniel, E. E.; Kingma, Y.J.

doi:10.1152/ajplegacy.1972.223.2.332

Cited by 42 publications

(30 citation statements)

References 1 publication

(6 reference statements)

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“…Kelly and coworkers (18,19) used 6 -10 extracellular electrodes sutured to the stomach to determine the origin and the pattern of propagation of the gastric slow wave. Similar studies were performed with electrodes oriented in the longitudinal direction along the greater curvature, midway between the greater and the lesser curvature, and oriented in the circular direction (7,20,34,35). All of these studies have expanded on the original concept of a slow wave that seemingly originates from the mid-or the upper corpus, does not activate the fundus, and propagates aborally with gradually increasing velocity and amplitude (42).…”

mentioning

confidence: 99%

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system

Lammers¹,

Donck²,

Stephen³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

115

178

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Slow waves are known to originate orally in the stomach and to propagate toward the antrum, but the exact location of the pacemaker and the precise pattern of propagation have not yet been studied. Using assemblies of 240 extracellular electrodes, simultaneous recordings of electrical activity were made on the fundus, corpus, and antrum in open abdominal anesthetized dogs. The signals were analyzed off-line, pathways of slow wave propagation were reconstructed, and slow wave velocities and amplitudes were measured. The gastric pacemaker is located in the upper part of the fundus, along the greater curvature. Extracellularly recorded slow waves in the pacemaker area exhibited large amplitudes (1.8 +/- 1.0 mV) and rapid velocities (1.5 +/- 0.9 cm/s), whereas propagation in the remainder of the fundus and in the corpus was slow (0.5 +/- 0.2 cm/s) with low-amplitude waveforms (0.8 +/- 0.5 mV). In the antrum, slow wave propagation was fast (1.5 +/- 0.6 cm/s) with large amplitude deflections (2.0 +/- 1.3 mV). Two areas were identified where slow waves did not propagate, the first in the oral medial fundus and the second distal in the antrum. Finally, recordings from the entire ventral surface revealed the presence of three to five simultaneously propagating slow waves. High resolution mapping of the origin and propagation of the slow wave in the canine stomach revealed areas of high amplitude and rapid velocity, areas with fractionated low amplitude and low velocity, and areas with no propagation; all these components together constitute the elements of a gastric conduction system.

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confidence: 99%

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system

Lammers¹,

Donck²,

Stephen³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

115

178

View full text Add to dashboard Cite

show abstract

“…Since the 1960s, when the pacemaker role of ICC was still unclear, GI electrical activity has been modeled as a series of coupled Van der Pol relaxation oscillators [27]. This concept was further expanded to demonstrate entrainment in a network of bi-directionally coupled series of relaxation oscillators [28], and was used to simulate the effects of partial cuts in GI organs on the electrical activity [29]. More recently, a cellular automaton model was developed to investigate the effects of tissue degradation on the overall GI electrical activity propagation, with the degradation being modeled as randomly distributed nodes throughout the simulation grid [26].…”

Section: Discussionmentioning

confidence: 99%

A Stochastic Algorithm for Generating Realistic Virtual Interstitial Cell of Cajal Networks

Gao

Sathar

O’Grady

et al. 2015

IEEE Trans. Biomed. Eng.

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Interstitial cells of Cajal (ICC) play a central role in coordinating normal gastrointestinal (GI) motility. Depletion of ICC numbers and network integrity contributes to major functional GI motility disorders. However, the mechanisms relating ICC structure to GI function and dysfunction remains unclear, partly because there is a lack of large-scale ICC network imaging data across a spectrum of depletion levels to guide models. Experimental imaging of these large-scale networks remains challenging because of technical constraints, and hence, we propose the generation of realistic virtual ICC networks in silico using the single normal equation simulation (SNESIM) algorithm. ICC network imaging data obtained from wild-type (normal) and 5-HT2B serotonin receptor knockout (depleted ICC) mice were used to inform the algorithm, and the virtual networks generated were assessed using ICC network structural metrics and biophysically based computational modeling. When the virtual networks were compared to the original networks, there was less than 10% error for four out of five structural metrics and all four functional measures. The SNESIM algorithm was then modified to enable the generation of ICC networks across a spectrum of depletion levels, and as a proof-of-concept, virtual networks were successfully generated with a range of structural and functional properties. The SNESIM and modified SNESIM algorithms, therefore, offer an alternative strategy for obtaining the large-scale ICC network imaging data across a spectrum of depletion levels. These models can be applied to accurately inform the physiological consequences of ICC depletion.

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“…Mathematical models of intestinal slow waves were formulated as early as the 1970s, 32,33 and since that time the subsequent research and development of the mathematical models of GI slow waves have been steadily gaining complexity as more experimental evidence regarding the electrophysiological roles of the ICCs and SMCs have become known. State-of-the-art GI mathematical modeling has now been applied to represent the normal propagation of gastric slow waves, and to explain the effects of dysrhythmia of gastric slow waves in the form of electrical functional uncoupling in the human stomach.…”

Section: Mathematical Models Of Gastrointestinal Electrical Activitymentioning

confidence: 99%

“…32,33 Although the relaxation-oscillator models reproduced entrainment (referred to as “frequency pulling” in the original literature), the lack of a physiological basis strongly inhibited the application of these models as in silico hypothesis testing tools. Attempts have been made to develop phenomenological models with a stronger cellular basis.…”

Section: Mathematical Models Of Gastrointestinal Electrical Activitymentioning

confidence: 99%

Multiscale Modeling of Gastrointestinal Electrophysiology and Experimental Validation

O’Grady

Davidson

et al. 2010

Crit Rev Biomed Eng

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Normal gastrointestinal (GI) motility results from the coordinated interplay of multiple cooperating mechanisms, both intrinsic and extrinsic to the GI tract. A fundamental component of this activity is an omnipresent electrical activity termed slow waves, which is generated and propagated by the interstitial cells of Cajal (ICCs). The role of ICC loss and network degradation in GI motility disorders is a significant area of ongoing research. This review examines recent progress in the multiscale modeling framework for effectively integrating a vast range of experimental data in GI electrophysiology, and outlines the prospect of how modeling can provide new insights into GI function in health and disease. The review begins with an overview of the GI tract and its electrophysiology, and then focuses on recent work on modeling GI electrical activity, spanning from cell to body biophysical scales. Mathematical cell models of the ICCs and smooth muscle cell are presented. The continuum framework of monodomain and bidomain models for tissue and organ models are then considered, and the forward techniques used to model the resultant body surface potential and magnetic field are discussed. The review then outlines recent progress in experimental support and validation of modeling, and concludes with a discussion on potential future research directions in this field.

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Effects of partial cuts on gastric electrical control activity and its computer model

Cited by 42 publications

References 1 publication

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system

A Stochastic Algorithm for Generating Realistic Virtual Interstitial Cell of Cajal Networks

Multiscale Modeling of Gastrointestinal Electrophysiology and Experimental Validation

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