Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study

Girolamo, Enrico Di; Iorio, Cesare Di; Sabatini, Panfilo; Leonzio, Luigi; Barbone, Carmela; Barsotti, Antonio

doi:10.1016/s0735-1097(98)00694-9

Cited by 279 publications

(108 citation statements)

References 22 publications

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“…There is no clinical evidence supporting the use of B-blockers (27) or paroxetine. (28) Cardiac pacing: a meta-analysis found contradictory evidence for the effect of cardiac pacing on neurally mediated syncope. (29) Pacing is very effective for sinus node disease (30) and in AV heart block, LVF and prolonged QRS.…”

Section: Psychogenic and Hyperventilation Syncopementioning

confidence: 99%

Syncope

2017

AGEMS

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Section: Psychogenic and Hyperventilation Syncopementioning

confidence: 99%

Syncope

2017

AGEMS

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“…[70][71][72] Results have been mixed and there remains considerable uncertainty about the effectiveness these drugs in preventing syncope.…”

Section: Selective Serotonin Reuptake Inhibitorsmentioning

confidence: 99%

Management of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncope

Raj

Sheldon

2016

Arrhythmia &Amp; Electrophysiology Review

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Postural tachycardia syndrome (POTS), inappropriate sinus tachycardia (IST) and vasovagal syncope (VVS) are relatively common clinical syndromes that are seen by physicians in several disciplines. They are often not well recognised and are poorly understood by physicians, are associated with significant morbidity and cause significant frustration for both patients and their physicians. The2015 Heart Rhythm Society Expert Consensus Statement on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncopeprovides physicians with an introduction to these disorders and initial recommendations on their investigation and treatment. Here we summarise the consensus statement to help physicians in the management of patients with these frequently distressing problems

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“…This change is postulated to prevent overstimulation of the postsynaptic area by a surge of serotonin. 30 Paroxetine, 31 fluoxetine, 32 and sertraline 33 are selective seroto-nin reuptake inhibitors useful in treating NMS. Although generally well tolerated, these drugs may cause anxiety, headache, or insomnia in some patients.…”

Section: Treatmentmentioning

confidence: 99%