Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves

Mattioli, Guillermo Alberto; Rosa, Diana Esther; Turic, Esteban; Picco, Sebastián Julio; Raggio, Santiago José; Minervino, Antônio Humberto Hamad; Fazzio, Luis Emilio

doi:10.3390/ani10081298

Cited by 22 publications

(27 citation statements)

References 52 publications

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“…Although plasma TAS has been effective in evaluating the antioxidant capacity in dairy cows ( Castillo et al, 2006 ; Gong and Xiao, 2016 ), in trials with calf transport plasma TAS response has been inconsistent. In a trial in calves that received similar supplementation to the one evaluated in the current experiment, weaned on pasture with a fence-line system and without subsequent transport, plasma TAS was greater in supplemented calves compared with nonsupplemented calves ( Mattioli et al, 2020 ). On the other hand, Chirase et al (2004) observed that plasma TAS decreased by only 10% in weaned and transported calves for 1,930 km and 20 h in transit.…”

Section: Discussionmentioning

confidence: 84%

“…The steers were randomly assigned to four treatments: 1) MVS+PC, steers with MVS and preconditioned, n = 15; 2) N+PC, steers with no MVS and preconditioned, n = 15; 3) MVS+N, steers with MVS and not preconditioned, n = 15; and 4) N+N, steers with no MVS and preconditioned, n = 15. The number of animals was selected based on a power analysis, using results from a previous research with the use of a similar MVS ( Mattioli et al, 2020 ). The mineral and vitamin treatment was applied subcutaneously (s.c.) at a dose of 1 mL/50 kg of BW.…”

Section: Methodsmentioning

confidence: 99%

“…Treatment MVS+N and MVS+PC received a s.c. injection of the mineral solution at a dose of 1 mL/50 kg BW and another s.c. injection of vitamins solution at the same dose. The dose of minerals and vitamins used has been evaluated in two supplementation experiments with calves around weaning ( Bordignon et al, 2019 ; Mattioli et al, 2020 ). In both experiments, applications of treatments were separated by 7 to 30 d, and improvements in average daily gain ( ADG ), immune response, and antioxidant capacity in dairy and beef calves were reported.…”

Section: Methodsmentioning

confidence: 99%

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Effect of preshipment preconditioning and injectable antioxidant trace elements (Cu, Mn, Se, Zn) and vitamins (A, E) on plasma metabolite and hormone concentrations and growth in weaned beef cattle

Galarza

Lizarraga

Mattioli

et al. 2021

Translational Animal Science

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Weaning and transport represent a high stress time for calves. Preconditioning (PC) by weaning before the transport separate these stressors. The stressors generate oxidative stress, which can be reduced by mineral and vitamin supplementation (MVS) with an antioxidant capacity. Our objective was to evaluate the effect of PC and MVS on performance of steers. The experiment used a 2 × 2 factorial arrangement design, considering a 26-d PC treatment from weaning to transport to the feedlot (day 0), and injectable MVS on days −45, −26, and 0. The MVS consisted of Cu, Zn, Mn, Se, vitamin E (0.2, 0.8, 0.2, 0.1, and 1 mg/kg body weight [BW], respectively), and vitamin A (1,190 IU/kg). Sixty Angus-crossbred steers (186.4 ± 27.6 kg) were randomly assigned to the four treatments (MVS+PC; N+PC; MVS+N; N+N; n = 15 per treatment). BW was recorded on days −45, −26, 0, 8, 15, and 29. On day 0, an additional BW was taken 30 min after the 5-h transportation (day 0.5). Between days 0 and 29, dry matter intake (DMI) and average daily gain (ADG) to DMI ratio (G:F) were measured. Between days −26 and 29 plasma concentrations of glucose, nonesterified fatty acids (NEFA), cortisol, insulin, total antioxidant status (TAS), and thiobarbituric acid-reactive substances were evaluated. Data were analyzed using the MIXED procedure of SAS with repeated measures, using treatment, time, and treatment × time as fixed effects and steer as a random effect. Between days −26 and 0, there was an interaction of MVS × PC (P ˂ 0.01) for ADG. From days −26 to 0, N+N and N+PC had the greatest and lesser ADG, respectively. On day 0.5, no-PC steers tended to lose BW, whereas the PC steers tended to gain BW (P = 0.09). In the period days 0 to 8, there were no differences (P ≥ 0.27) in DMI, but the PC steers had greater G:F and ADG (P < 0.01) compared with no-PC steers. Plasma NEFA concentration on day 0 was affected by MVS × PC (P < 0.01) because MVS decreased plasma NEFA concentration in no-PC steers, but it increased in the PC steers. Plasma concentrations of glucose, insulin, and cortisol did not differ among treatments (P ≥ 0.23). There was an MVS × PC interaction (P = 0.09) for TAS on day 0; N+N had the greatest TAS concentrations and MVS+N had the lowest TAS concentrations. In conclusion, a 26-d PC decreased steers BW compared with no-PC steers. The BW loss during PC was not recovered 29 d after feedlot entry. Despite this BW loss, MVS treatment decreased BW loss in the steers allocated to PC treatment on the day of transport.

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Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effect of preshipment preconditioning and injectable antioxidant trace elements (Cu, Mn, Se, Zn) and vitamins (A, E) on plasma metabolite and hormone concentrations and growth in weaned beef cattle

Galarza

Lizarraga

Mattioli

et al. 2021

Translational Animal Science

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“…Elevated ROS production compromises genomic stability and disrupts protein and lipid structures (Koch and Hill, 2017), overwhelming cellular antioxidant defense system (Burton and Jauniaux, 2011). Supplemental antioxidants delay or inhibit oxidation of the oxidizable substrates (Betteridge, 2000) that play an important role for the immune defense and health of stressed cattle (McDowell, 2000;Mattioli et al, 2020). Antioxidants such as Vitamin E and β-carotene are considered chain-breaking antioxidant (Betteridge, 2000;McDowell, 2000;Baj et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidants such as Vitamin E and β-carotene are considered chain-breaking antioxidant (Betteridge, 2000;McDowell, 2000;Baj et al, 2019). Accordingly, these two vitamins are routinely supplemented in receiving diets to counteract pro-oxidant status, promoting both health and growth performance (Alosilla Jr et al, 2007;Abuelo et al, 2015;Mattioli et al, 2020). In vivo and in vitro Vitamin A and E evaluations indicate a greater efficiency of utilization when supplemented parenterally rather than orally (Rode et al, 1990;McDowell, 2000;Snider et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Vitamin A and E Forms Influence Differently the Plasma Vitamin Concentrations in Newly Received Calves

Buenabad¹,

Barreras²,

Plascencia³

et al. 2021

American Journal of Animal and Veterinary Sciences

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Ten Holstein steer calves (105±3 kg) were used to evaluate bioavailability of two Vitamin A or E forms, "natural" (EA1) or "synthetic" (EA2), based on plasma vitamin concentrations during a 3-d period post injection(subcutaneous). Plasma retinyl palmitate and plasma Vitamin A concentration (retinol equivalent of all forms) was greater 24 and 48 h (P<0.01) post injection of retinyl palmitate vs retinyl propionate. Likewise, plasma retinol was greater (P = 0.04) 72 h post injection of retinyl palmitate. Plasma retinyl propionate was undetected for either treatment, indicative that it is not absorbed as a parent compound. Plasma retinyl palmitate, retinol and total Vitamin A concentrations peaked 24 h (P<0.01) post injection, decreasing toward baseline levels by 72 h post injection. Plasma tocopherol concentration was greater 24 h post injection (P<0.01) for calves injected with D-α-tocopherol vs DL-α-tocopherol. Levels were not different among treatments 48 h post injection (P>0.10). Plasma tocopherol concentrations were maximal (P<0.01) 24 h post injection of D-α-tocopherol, promptly decreasing by 72 h post injection (a level comparable to that observed with DL-α-tocopherol injection). We concluded that based on plasma concentrations, bioavailability of parenterally supplemented retinyl palmitate and D-α-tocopherol are greater than that of retinyl propionate and DL-α-tocopherol under acute Vitamin A or E supplementation.

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Effect of injectable trace mineral at weaning on growth and physiology of Nellore calves under feed restriction

Zornitta

D’Oliveira

Bento

et al. 2021

Trop Anim Health Prod

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Calves are susceptible to a wide variety of stressors besides the seasoning low forage availability during their weaning phase. Thus, it is ideal if they receive adequate trace mineral supplementation during this period. This study evaluated the effect of injectable trace minerals (ITM) on performance, concentration of oxidative stress enzymes, and biochemical plasmatic parameters in Nellore calves during the weaning phase and under feed restriction. A total of 30 Nellore calves were used at the age of 7 ± 1 month and 176.23 ± 21.68 kg of initial body weight (BW). These animals were allocated in Urochloa decumbens pasture for 28 days and transferred to Urochloa brizantha cv Marandu pasture for another 28 days. The treatments were: Saline (saline solution; 0.9% NaCl) and ITM (Multimin®, providing: 15 mg Cu/mL, 60 mg Zn/mL, 10 mg Mn/ mL, and 5 mg Se/mL). Both treatments were applied subcutaneously in the ratio of 1 mL/45 kg of BW. At the end of the experiment (d 56), animals were lighter than on d 0 in both treatments (P < 0.05). However, calves that received the ITM treatment presented lower body weight (P < 0.05) on d 56, compared to those in the control group. No significant difference (P > 0.05) was observed on the concentrations of oxidative stress enzymes. Moreover, no significant difference (P > 0.05) was observed in the plasmatic parameters; these were at normal range or slightly below the concentrations described for the species. We concluded that, in a feed restriction condition, the use of ITM in weaned calves did not improve performance, and the concentration of oxidative stress enzymes, and biochemistry variables. Therefore, we do not recommend using injectable trace minerals in the concentrations used in this study in animals under such stressful conditions.

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Effects of Parenteral Supplementation with Minerals and Vitamins on Oxidative Stress and Humoral Immune Response of Weaning Calves

Cited by 22 publications

References 52 publications

Effect of preshipment preconditioning and injectable antioxidant trace elements (Cu, Mn, Se, Zn) and vitamins (A, E) on plasma metabolite and hormone concentrations and growth in weaned beef cattle

Effect of preshipment preconditioning and injectable antioxidant trace elements (Cu, Mn, Se, Zn) and vitamins (A, E) on plasma metabolite and hormone concentrations and growth in weaned beef cattle

The Vitamin A and E Forms Influence Differently the Plasma Vitamin Concentrations in Newly Received Calves

Effect of injectable trace mineral at weaning on growth and physiology of Nellore calves under feed restriction

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