Effects of parenteral structured lipid emulsion on modulating the inflammatory response in rats undergoing a total gastrectomy

Lin, Ming Tsan; Yeh, Sung Ling; Tsou, Sing-Hua; Wang, Ming Yang; Chen, Wei Jao

doi:10.1016/j.nut.2008.07.015

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…No significant differences in the respiratory quotient, energy expenditure, or glucose or triglyceride levels were observed between the LCT-and STs-treated groups (22). In a recent study, STs were observed to generate lower plasma levels of leukocyte integrin expression, indicating lower inflammatory effect (23). Furthermore, STs have no effect on mononuclear phagocytic system function, does not stimulate pro-inflammatory mediator production, and alters liver function to a lesser extent than LCT-and MCT-based emulsions (21,24).…”

Section: Evolution Of Parenteral Nutrition Emulsionsmentioning

confidence: 84%

Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

2010

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Injectable lipid emulsions, for decades, have been clinically used as an energy source for hospitalized patients by providing essential fatty acids and vitamins. Recent interest in utilizing lipid emulsions for delivering lipid soluble therapeutic agents, intravenously, has been continuously growing due to the biocompatible nature of the lipid-based delivery systems. Advancements in the area of novel lipids (olive oil and fish oil) have opened a new area for future clinical application of lipid-based injectable delivery systems that may provide a better safety profile over traditionally used long- and medium-chain triglycerides to critically ill patients. Formulation components and process parameters play critical role in the success of lipid injectable emulsions as drug delivery vehicles and hence need to be well integrated in the formulation development strategies. Physico-chemical properties of active therapeutic agents significantly impact pharmacokinetics and tissue disposition following intravenous administration of drug-containing lipid emulsion and hence need special attention while selecting such delivery vehicles. In summary, this review provides a broad overview of recent advancements in the field of novel lipids, opportunities for intravenous drug delivery, and challenges associated with injectable lipid emulsions.

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Section: Evolution Of Parenteral Nutrition Emulsionsmentioning

confidence: 84%

Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

2010

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“…The results indicated that STG emulsions can improve cellular and humoral immune function. Several clinical and experimental studies [ 15 ] have suggested that while fat emulsion provides essential fatty acids and energy, it can impair immune function and increase the risk of infection, and the mechanism by which it does this is mainly related to fatty acids. Fatty acids are an important component of cell membranes, and the carbon chain length and saturation of the fatty acids in cell membranes play important roles in immune cell interactions.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Structured Triglyceride versus Physical Mixture Medium- and Long-Chain Triglycerides for PN in Liver Resection Patients

Zhao

Wang

2017

BioMed Research International

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Background The use of total parenteral nutrition can affect liver function, causing a series of problems such as cholestasis. The aim of this meta-analysis was to compare structured triglyceride- (STG-) based lipid emulsions with physical medium-chain triglyceride (MCT)/long-chain triglyceride (LCT) mixtures in patients who had undergone liver surgery to identify any differences between these two types of parenteral nutrition. Methods We searched the databases of PubMed, the Cochrane Library, Web of Science, EMBASE, and Chinese Biomedicine Database from January 2007 to March 2017 and included studies that compared STG-based lipid emulsions with physical MCT/LCT mixtures for surgical patients with liver disease. Conclusion The STG was more beneficial than physical MCT/LCT on recovery of liver function and immune function. Therefore, STGs may represent a promising alternative to other types of lipid emulsions for hepatic surgery patients.

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“…Decreasing this acute effect in the postprandial plasma compartment may protect against chronic inflammation of adipose and other tissues, which can predispose patients to insulin resistance and diabetes. Results of several in vitro and animal studies suggest that dietary FA composition and availability can modulate inflammatory responsiveness (39,40,50). The differing availability of saturated LCFAs from interesterified fats compared with unmodified TGs has the potential to change postprandial inflammation, because palmitate and stearate are known to induce various inflammatory responses in vitro (40).…”

Section: Postprandial Inflammation Interest In the Postprandial Infla...mentioning

confidence: 99%

“…The in vivo relevance for humans is not currently known. Leukocyte activation markers were reduced in vivo when rats received parenteral MCFAs as structured TGs compared with unmodified TGs after gastrectomy surgery (50). However, monocyte chemotactic protein-1 and macrophage inflammatory protein-2 concentrations in peritoneal lavage fluid were elevated by consumption of the structured TG, leaving the relative risk or benefit open to discussion.…”

Section: Postprandial Inflammation Interest In the Postprandial Infla...mentioning

confidence: 99%

The Increasing Use of Interesterified Lipids in the Food Supply and Their Effects on Health Parameters

Mensink

Sanders

Baer

et al. 2016

Advances in Nutrition

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A variety of modified fats that provide different functionalities are used in processed foods to optimize product characteristics and nutrient composition. Partial hydrogenation results in the formation of trans FAs (TFAs) and was one of the most widely used modification processes of fats and oils. However, the negative effects of commercially produced TFAs on serum lipoproteins and risk for cardiovascular disease resulted in the Institute of Medicine and the 2010 US Dietary Guidelines for Americans both recommending that TFA intake be as low as possible. After its tentative 2013 determination that use of partially hydrogenated oils is not generally regarded as safe, the FDA released its final determination of the same in 2015. Many food technologists have turned to interesterified fat as a replacement. Interesterification rearranges FAs within and between a triglyceride molecule by use of either a chemical catalyst or an enzyme. Although there is clear utility of interesterified fats for retaining functional properties of food, the nutrition and health implications of long-term interesterified fat consumption are less well understood. The Technical Committee on Dietary Lipids of the North American Branch of the International Life Sciences Institute sponsored a workshop to discuss the health effects of interesterified fats, identify research needs, and outline considerations for the design of future studies. The consensus was that although interesterified fat production is a feasible and economically viable solution for replacing dietary TFAs, outstanding questions must be answered regarding the effects of interesterification on modifying certain aspects of lipid and glucose metabolism, inflammatory responses, hemostatic parameters, and satiety.

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Effects of parenteral structured lipid emulsion on modulating the inflammatory response in rats undergoing a total gastrectomy

Cited by 11 publications

References 30 publications

Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

Injectable Lipid Emulsions—Advancements, Opportunities and Challenges

Meta-Analysis of Structured Triglyceride versus Physical Mixture Medium- and Long-Chain Triglycerides for PN in Liver Resection Patients

The Increasing Use of Interesterified Lipids in the Food Supply and Their Effects on Health Parameters

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