Effects of Parenteral Nutrition Formulas on Plasma Lipid Profile in Children with Bone Marrow Transplantation

Abstract

Background/Aims: Children undergoing bone marrow transplantation (BMT) often require parenteral nutrition (PN). This is a comparative study of plasma lipid profiles in BMT children after fish oil or soybean PN. Methods: A total of 14 children with BMT requiring PN for at least 10 days were recruited during 24 months. They were randomized to receive a lipid emulsion enriched with ω3 polyunsaturated fatty acid, or soybean oil. Clinical monitoring was performed. Blood samples were collected before and after administration of PN to analyze the lipid profile. Results: There were no complications associated with PN. The increase in TG levels was more pronounced after administration of an enriched ω3 emulsion and the decrease in cHDL and apo A was greater after administration of soybean. The ω3 group showed an increase in eicosapentaenoic and a decrease in arachidonic acids compared to the soybean group. Both groups showed similar levels of linolenic acid. Conclusion: PN with soybean or ω3 emulsions for 10 days is safe in children. However, research in children are necessary in order to examine the impact of the duration of PN and the type of lipid formula used, and determine their health benefits in relation to the fatty acid profile.

Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation

“…As previously described, no statistically significant differences were found between the two groups in terms of patient age, sex, primary pathology, or type of HSCT [ 27 ]. In addition, patients in both groups showed different degrees of mucositis, GVHD, and VOD.…”

“…Our results did not show differences in the development of clinical complications between the groups. However, plasma levels of linoleic acid [ 27 ] and some inflammatory factors increased in the patients who received the soybean emulsion as compared with the FO group.…”

Inflammatory Response Using Different Lipid Parenteral Nutrition Formulas in Children After Hematopoietic Stem Cell Transplantation

“…To compare all these studies is a difficult exercise due to heterogeneity of methods used or population in terms of characteristics, age, and pathology. In our clinical trial, despite the limitations given the small sample size, both groups showed similar demographic characteristics and clinical complications (21), and received PN for equal number of days. Furthermore, all HSCT children were monitored conforming to the HSCT protocols of the procedure.…”

“…There were no statistically significant differences among the groups in terms of patient age, sex, primary pathology, type of HSCT, degrees of mucositis, GVHD, VOD, and also in the total days of PN or in the number of hospitalization days. These data are described in Table 1 (21).…”

The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation

“…Several studies have revised the effects of PN in children with HSCT [ 3 , 4 , 7 ]. However, only a few addressed the question of the potential effects of enriched FO lipid emulsions compared with standard lipid emulsions [ 17 , 18 , 19 ]. We have previously shown that PN containing SO or long-chain polyunsaturated (LC-PUFA) ω-3 FAs enriched emulsions for ten days is safe for children [ 17 ].…”