Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs

Abstract

The effect of enrofloxacin on the QT interval of the electrocardiogram was studied in 30 hospitalized dogs. The experimental group (n = 15) received enrofloxacin parenterally (subcutaneously) at a dose of 5 mg/kg twice daily and amoxicillin-clavulanate intravenously at a dose of 22 mg/kg three times daily. The control group (n = 15) received only amoxicillinclavulanate. Electrocardiography was carried out for 5 min once daily for 6 days. The QT interval was corrected by four different formulae. No differences were found between the two groups or within each group for the duration of the study. On the last day of the study the average QT interval for the control and experimental groups was 213.2 ms and 202.9 ms, respectively. Enrofloxacin did not cause prolongation of the QT or corrected QT intervals. We can conclude that the parenteral administration of enrofloxacin in non-cardiac dogs does not adversely affect the electrocardiographic indicators (no prolongation of the QT or corrected QT interval) and does not induce ventricular arrhythmias. Parenteral use of enrofloxacin is thus safe and effective in non-cardiac dogs.

Influence of long-term oral application of quinolones on the ECG curve in dogs

“…The authors did not calculate the QTc interval. Quinolones were administered for the longest period of time in the study by Agudelo-Ramirez et al (2012). In their study on dogs, they administered enrofloxacin twice a day subcutaneously at a dose of 5 mg/kg and carried out daily ECG examinations.…”

“…Therefore, we can observe a significant lengthening of this potential in the M cell layer without significant changes in the action potential in other layers. This leads to a notable increase of the transmural dispersion of repolarization (Antzelevitch 2004, Chanoit et al 2005, Agudelo-Ramirez et al 2012. TpTe/QT index is an even more sensitive indicator of the risk of arrhythmia as it eliminates the effect of distorting factors, such as the heart rhythm and the QT interval (Ghaffari and Parsamehr 2009).…”