Effects of Parecoxib on The Prevention of Postoperative Peritoneal Adhesions in Rats

Arung, Willy; Jehaes, F.; Cheramy, Jean-Paul; Defraigne, Jean-Olivier; Meurisse, Michel; Honoré, Pierre; Drion, Pierre; Detry, Olivier

doi:10.3109/08941939.2013.810316

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…31 Similarly, inhibition of COX-2 by the administration of parecoxib, celecoxib, rofecoxib and nimesulide has been shown to decrease adhesion formation in animal models. 32,33,34,35 Guvenal et al associated the effects of nimesulide in its study to its anti-prostaglandin activity and the reduction of the production of anti-angiogenic cytokines. 34 However, in a study by Keskin et al, where Meloxicam and Dexketoprofen were evaluated in a rat uterine horn surgical model, it was shown that Meloxicam decreased the development of inflammation.…”

Section: Original Articlementioning

confidence: 99%

Meloxicam Decreases the Formation of Peritoneal Adhesions in an Experimental Surgical Model in Rats

2017

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Background: Inflammatory adhesions result from an inflammatory response of the peritoneum during an intra-abdominal inflammatory process secondary to thermal or mechanical injury, infection, radiation, ischemia, dissection, abrasion or foreign body reaction. Adhesions produce consequences such as: infertility, intestinal obstruction, and pelvic-abdominal pain. The objective of this study is to evaluate the effects of Meloxicam, a selective cyclooxygenase-2 inhibitor, on the formation of postoperative peritoneal adhesions in an experimental animal model. Methods: Twenty female Wistar rats were submitted to laparotomy. Postoperative peritoneal adhesions were induced by scorching the serous surface of the colon. The animals were randomly divided into two experimental groups: one group received Meloxicam intramuscularly for 7 days, and the other served as a control group. They were sacrificed and evaluated at 15 days. Results: In the animals given Meloxicam, it was observed that a decrease in number (p = 0.018), severity (p = 0.004), extension (p = 0.011), density (p = 0.023), degree of inflammation (p = 0.002), vascular proliferation (p = 0.004) and fibrosis (p = 0.029) of adhesions, compared to the control group. Conclusion: In conclusion, this study demonstrated that the administration of Meloxicam intramuscularly significantly decreases the formation of postoperative peritoneal adhesions and, therefore, may be useful in their prevention. The effects of Meloxicam could not only be due to its anti-inflammatory action, but also to its effects on the expression of the Vascular Endothelial Growth Factor.

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Section: Original Articlementioning

confidence: 99%

Meloxicam Decreases the Formation of Peritoneal Adhesions in an Experimental Surgical Model in Rats

2017

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“…In addition, parecoxib administration did not cause healing defects or infectious complications, showing that, in these rat models, parecoxib might reduce adhesions formation and stimulate further investigation in other species [76]. …”

Section: Reviewmentioning

confidence: 99%

Peritoneal Response to Abdominal Surgery: The Role of Equine Abdominal Adhesions and Current Prophylactic Strategies

Alonso

Alves

Watanabe

et al. 2014

Veterinary Medicine International

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Intra-abdominal adhesions constitute a significant clinical and surgical problem that can lead to complications such as pain and bowel occlusion or subocclusion. These adhesions are frustrating and potentially fatal, representing a major postoperative complication in abdominal surgery. It is estimated that 32% of horses undergoing laparotomy will present clinical symptoms due to adhesions, but the true prevalence is not known because a large proportion of animals with postoperative recurrent colics are medically treated or submitted to euthanasia without necropsy. Adhesions are highly cellular, vascularized, dynamic structures that are influenced by complex signaling mechanisms. Understanding their pathogenesis could assist in applying better therapeutic strategies and in developing more effective antiadhesion products. Currently, there are no definitive strategies that prevent adhesion formation, and it is difficult to interpret the results of existing studies due to nonstandardization of an induction model and evaluation of their severity. The best clinical results have been obtained from using minimally traumatic surgical techniques, anti-inflammatory agents, antimicrobials, anticoagulants, and mechanical separation of serosal surfaces by viscous intraperitoneal solutions or physical barriers. This paper aims to review adhesion formation pathogenesis, guide the understanding of major products and drugs used to inhibit adhesion formation, and address their effectiveness in the equine species.

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“…[1,2] Several agents aimed at preventing postoperative peritoneal adhesions (PPAs) have been investigated in animal models. [3][4][5]. They might be effective in diminishing the inflammatory response, inhibiting collagen synthesis, activating fibrinolysis, hampering coagulation, or creating a barrier between adjacent wound surfaces.…”

Section: Introductionmentioning

confidence: 97%

Sepramesh and postoperative peritoneal adhesions in a rat model

Arung

Drion

Detry

2016

Acta Chirurgica Belgica

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Effects of Parecoxib on The Prevention of Postoperative Peritoneal Adhesions in Rats

Abstract: This study showed that, in these rat models, parecoxib might reduce PPA formation. Confirmation of the safety of parecoxib on intestinal anastomoses is required and should be investigated in further animal models.

Cited by 12 publications

References 28 publications

Meloxicam Decreases the Formation of Peritoneal Adhesions in an Experimental Surgical Model in Rats

Meloxicam Decreases the Formation of Peritoneal Adhesions in an Experimental Surgical Model in Rats

Peritoneal Response to Abdominal Surgery: The Role of Equine Abdominal Adhesions and Current Prophylactic Strategies

Sepramesh and postoperative peritoneal adhesions in a rat model

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