Effects of Parathyroid Hormone-Related Protein on Systemic and Regional Hemodynamics in Conscious Rats

Kishimoto, Hiroshi; Tsumura, Kei; Fujioka, Shoji; Uchimoto, Sadahiko; Yamashita, Naotoshi; Suzuki, Ryoko; Yoshimaru, Kiyomichi; Shimura, Masahiko; Sasakawa, Osamu; Morii, H

doi:10.1159/000420126

Cited by 3 publications

(4 citation statements)

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“…In accord, declines in mean arterial pressure in male Sprague Dawley rats to PTHrP 1-34 were markedly greater than those observed declines to PTH 1-34, representing a 3-fold differential response [39]. Vasodilator responsiveness to PTH 1-84, PTH 1-34, and PTHrP 1-34 can translate into physiological increases in blood flow and tissue perfusion [21,22,39,40]. For example, increases in mammary blood flow were observed subsequent to infusion of PTHrP 1-34 [41].…”

Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 60%

“…Similarly, vasodilation to PTHrP 1-34 was more robust than to PTH 1-34 in mouse portal vein preparations [37] and in rabbit renal arteries [38]. In accord, declines in mean arterial pressure in male Sprague Dawley rats to PTHrP 1-34 were markedly greater than those observed declines to PTH 1-34, representing a 3-fold differential response [39]. Vasodilator responsiveness to PTH 1-84, PTH 1-34, and PTHrP 1-34 can translate into physiological increases in blood flow and tissue perfusion [21,22,39,40].…”

Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 94%

“…While the actions of PTH and PTHrP on the systemic vasculature has been well documented [21,22,39,40,56], little information has been discerned regarding the vasodilator properties of PTH [9] and PTHrP on isolated bone blood vessels. We demonstrated, for the first time, vasodilator responsiveness of bone blood vessels to PTHrP 1-34.…”

Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 99%

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Mechanisms of vasodilation to PTH 1–84, PTH 1–34, and PTHrP 1–34 in rat bone resistance arteries

et al. 2016

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Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 60%

Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 94%

Section: Vasodilator Responses Of Intact and Denuded Femoral Pnas To Snpmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of vasodilation to PTH 1–84, PTH 1–34, and PTHrP 1–34 in rat bone resistance arteries

et al. 2016

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“…Both peptides inducing a prominent vasodilation and positive chronotropic and inotropic effects on the heart E5,6] appear to have an important role in regulating blood pressure and regional heraodynamics [7].…”

Section: Introductionmentioning

confidence: 99%

Hypercalcemia induced by acute norepinephrine infusion is not mediated by PTH nor PTHrP secretion in man

et al. 1994

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Abstract:Parathyroid hormone (PTH), when acutely infused, exerts potent cardiovascular action in man, such as: hypotension and positive chronotropic and inotropic effects. Parathyroid hormone-related protein (PTHrP) also induces hypotension and positive inotropic and chronotropic effect in the rat, and an influence of the adrenergic system on PTH and PTHrP secretion has been postulated. Therefore, the aim of the present study was to evaluate the effect of an acute norepinephrine (NE) infusion on blood pressure (BP), heart rate (HR), serum total (tCa) and ionized calcium (+ +Ca), cyclic 3'-5' AMP (cAMP), immunoreactive intact E1-84] PTH and PTHrP levels in 5 healthy normotensive subjects, before and after a pretreatment with a beta-blocking agent, pindolol. NE, when acutely infused for 10 rain, induced a significant increase in systolic and diastolic BP from the 10th to the 20th min, with a parallel significant decrease in HR, a significant increase in serum tCa and + +Ca and cAMP, with a parallel significant decrease in intact iPTH levels. Serum iPTHrP, during NE infusion, did not change from the baseline values. During pindolol, NE infusion did not induce any significant change in systolic and diastolic BP, in serum tCa and + + Ca, cAMP, intact iPTH and iPTHrP levels. Our results suggest that NE induces acute hypercalcemia which is not mediated by PTH nor PTHrP secretion. Hypercalcemic effect of NE seems to be mediated by adrenergic system, since it is abolished by a beta-blockingagent. Conversely, the significant decrease of serum intact iPTH is probably due to the hypercalcemic effect of NE. However, the involvement of other systems in the action of NE, like prostaglandin or RAA system, cannot be excluded.

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Age-related decrease in the effect of parathyroid hormone-related protein on cytosolic free calcium level and tension in rat aortic smooth muscle

Ishikawa

Ouchi

Akishita

et al. 1995

Naunyn-Schmiedeberg's Arch Pharmacol

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Age-related changes in the effect of parathyroid hormone-related protein (PTHrP) on the cytosolic free calcium level ([Ca2+]i) and on the tension in rat aortic smooth muscle were investigated. The possible involvement of cAMP, a second messenger of PTHrP, in such changes was also investigated. Spiral aortic strip preparations without endothelium from 8-weeks, 6-months, and 24-months old rats were treated with fura 2/AM, and the fluorescence ratio R340/380, an index of [Ca2+]i was measured. Simultaneously, the tension of the preparations was measured. PTHrP-(1-34) and dibutyryl cAMP produced concentration-dependent decreases in the tension and in R340/380 in aortas precontracted with phenylephrine (10(-7) M). These effects were significantly lower in the aortas of 24-months old rats than in the vessels of 8-weeks and 6-months old rats. The effects were similar in the aortas of 8-weeks and 6-months old rats. PTHrP-(1-34) concentration-dependently increased cAMP production in vascular smooth muscle cells (VSMCs) from 8-weeks old rats. However, the increase in cAMP production was significantly lower in cultured VSMCs from 6-months and 24-months old rats than in cells from 8-weeks old rats. These results suggest that the reduced cAMP production stimulated by PTHrP and the reduced effects of cAMP with aging might contribute to the age-related changes in the decreases in tension and [Ca2+]i in response to PTHrP in the rat aorta.

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Effects of Parathyroid Hormone-Related Protein on Systemic and Regional Hemodynamics in Conscious Rats

Cited by 3 publications

References 0 publications

Mechanisms of vasodilation to PTH 1–84, PTH 1–34, and PTHrP 1–34 in rat bone resistance arteries

Mechanisms of vasodilation to PTH 1–84, PTH 1–34, and PTHrP 1–34 in rat bone resistance arteries

Hypercalcemia induced by acute norepinephrine infusion is not mediated by PTH nor PTHrP secretion in man

Age-related decrease in the effect of parathyroid hormone-related protein on cytosolic free calcium level and tension in rat aortic smooth muscle

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