Effects of Parathyroid Hormonal Peptides on the Gut1

Cooper, Cary W.; Seitz, Patricia K.; McPherson, M. Blaire; Selvanayagam, Peter; Rajaraman, Srinivasan

doi:10.1159/000420154

Cited by 7 publications

(8 citation statements)

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“…Since PTHrP‐induced reduction in the basal tension was diminished by SQ22536, an AC inhibitor, this inhibitory action of PTHrP is likely attributed to the increase in intracellular cAMP. This is in concordance with previous studies demonstrating that PTHrP relaxes smooth muscle in gastric fundus by increasing cAMP levels . In the previous study, expression of PTH/PTHrPR mRNA was observed in the rat gastric fundus .…”

Section: Discussionsupporting

confidence: 93%

Mechanisms of PTHrP‐induced inhibition of smooth muscle contractility in the guinea pig gastric antrum

Ohguchi

Mitsui

Imaeda

et al. 2017

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 93%

Mechanisms of PTHrP‐induced inhibition of smooth muscle contractility in the guinea pig gastric antrum

Ohguchi

Mitsui

Imaeda

et al. 2017

Neurogastroenterology Motil

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“…The latter suggestion has been derived from observations reported in several case reports and one observational study that primary hyperparathyroidism, a medical condition that results in higher PTH concentration, is associated with colon cancer (2-5) and that both normal and malignant colonic cells express PTH receptors (6-9). It has been proposed that PTH may affect cancer risk directly via mitogenic and anti-apoptotic effects (1, 10), or indirectly via a number of different mechanisms (1).…”

Section: Introductionmentioning

confidence: 99%

Prediagnostic Circulating Parathyroid Hormone Concentration and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Fedirko

Riboli

Bueno‐de‐Mesquita³

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods A case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating pre-diagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95%CI) for the association between circulating PTH and CRC risk. Results In multivariate analyses (including adjustment for 25(OH)D concentration) with a priori defined cut-points, high levels of serum PTH (≥65ng/L) compared to medium PTH levels of 30–65 ng/L were associated with increased CRC risk (RR=1.41, 95%CI: 1.03-1.93). In analyses by sex, the CRC risk was 1.77 (95%CI: 1.14-2.75) and 1.15 (95%CI: 0.73-1.84) in men and women, respectively (Pheterogeneity=0.01). In sub-group analyses by anatomical sub-site, the risk for colon cancer was RR=1.56, 95%CI:1.03-2.34, and for rectal cancer RR=1.20, 95%CI:0.72-2.01 (Pheterogeneity=0.21). Effect modification by various risk factors was examined. Conclusions The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.

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“…6 In adult tissues, its production level is low and PTHrP mRNA has been demonstrated in the muscle layer along with a faint signal in the mucosa. 7 Contraction or distension of the stomach is a trigger for PTHrP mRNA synthesis. 6 Gene expression of the PTH/PTHrP receptor has also been demonstrated in many tissues 8 and PTHrP elicits physiological effects through the PTH/PTHrP receptor in an autocrine/paracrine fashion.…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of parathyroid hormone‐related peptide on stress‐induced gastric hypercontraction in the rat

Ito

Nakashima²,

Nakayama³

et al. 2002

J of Gastro and Hepatol

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Effects of Parathyroid Hormonal Peptides on the Gut1

Cited by 7 publications

References 0 publications

Mechanisms of PTHrP‐induced inhibition of smooth muscle contractility in the guinea pig gastric antrum

Mechanisms of PTHrP‐induced inhibition of smooth muscle contractility in the guinea pig gastric antrum

Prediagnostic Circulating Parathyroid Hormone Concentration and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Preventive effects of parathyroid hormone‐related peptide on stress‐induced gastric hypercontraction in the rat

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