Effects of paradigm and inter-stimulus interval on age differences in eyeblink classical conditioning in rabbits

Woodruff-Pak, Diana S.; Seta, Susan E.; Roker, LaToya A.; Lehr, Melissa A.

doi:10.1101/lm.504107

Cited by 11 publications

(16 citation statements)

References 63 publications

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“…Previous work in our laboratory with the 750 ms ISI in New Zealand white rabbits (Woodruff-Pak et al, 2007) and the 500 ms ISI in C57BL/6 mice (Spath and Woodruff-Pak, 2004) indicated that when ISIs are matched in the trace and delay paradigms, acquisition in trace is slower and reaches a lower asymptote. ISI-matched delay and trace eyeblink conditioning tasks differentially engage forebrain circuitry associated with higher-order learning and memory paradigms (Moyer et al, 1990; Ivkovich and Stanton, 2001; Green and Arenos, 2007).…”

Section: Introductionmentioning

confidence: 87%

Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice

Brown¹,

Comalli²,

Biasi³

et al. 2010

Front. Behav. Neurosci.

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Nicotinic acetylcholine receptors (nAChRs) are essentially involved in learning and memory. A neurobiologically and behaviorally well-characterized measure of learning and memory, eyeblink classical conditioning, is sensitive to disruptions in acetylcholine neurotransmission. The two most common forms of eyeblink classical conditioning – the delay and trace paradigms – differentially engage forebrain areas densely-populated with nAChRs. The present study used genetically modified mice to investigate the effects of selective nAChR subunit deletion on delay and trace eyeblink classical conditioning. α7 and β2 nAChR subunit knockout (KO) mice and their wild-type littermates were trained for 10 daily sessions in a 500-ms delay or 500-ms trace eyeblink conditioning task, matched for the interstimulus interval between conditioned stimulus and unconditioned stimulus onset. Impairments in conditioned responding were found in α7 KO mice trained in trace – but not delay – eyeblink conditioning. Relative to littermate controls, β2 KO mice were unimpaired in the trace task but displayed higher levels of conditioned responding in delay eyeblink conditioning. Elevated conditioned response levels in delay-conditioned β2 KOs corresponded to elevated levels of alpha responding in this group. These findings suggest that α7 nAChRs play a role in normal acquisition of 500 ms trace eyeblink classical conditioning in mice. The prominent distribution of α7 nAChRs in the hippocampus and other forebrain regions may account for these genotype-specific acquisition effects in this hippocampus-dependent trace paradigm.

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Section: Introductionmentioning

confidence: 87%

Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice

Brown¹,

Comalli²,

Biasi³

et al. 2010

Front. Behav. Neurosci.

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“…We have also demonstrated that, in addition to increasing Aβ, cholesterol-enriched diets increase tau phosphorylation and oxidative stress in rabbits (Ghribi et al, 2006 a,b). Additionally, the eye blink classical conditioning that is impaired in AD patients is also impaired in the rabbit model (Woodruff-Pak et al, 2007. Schreurs et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

Marwarha

Ghribi

2015

Experimental Gerontology

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Alzheimer’s disease (AD), the most common form of dementia, is characterized histopathologically by the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles-containing hyperphosphorylated tau protein in the brain. Parkinson’s disease (PD), the most common movement disorder, is characterized by the aggregation of α-synuclein protein in Lewy body inclusions and the death of dopaminergic neurons in the substantia nigra. Based on their pathological signatures, AD and PD can be considered as two different disease entities. However, a subpopulation of PD patients also exhibit Aβ plaques, and AD patients exhibit α-synuclein aggregates. This overlap between PD and AD suggests that common pathological pathways exist for the two diseases. Identification of factors and cellular mechanisms by which these factors can trigger pathological hallmarks for AD/PD overlap may help in designing disease-modifying therapies that can reverse or stop the progression of AD and PD. For the last decade, work in our laboratory has shown that fluctuations in the levels of cholesterol oxidation products (oxysterols) may correlate with the onset of AD and PD. In this review, we will provide results from our laboratory and data from literature that converge to strongly suggest the involvement of cholesterol and cholesterol oxidation products in the pathogenesis of AD and PD. We will specifically delineate the role of and the underlying mechanisms by which increased levels of the oxysterol 27-hydroxycholesterol contribute to the pathogenesis of AD, PD, and AD/PD overlap.

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“…Many animals, ranging from worms to humans, show a decline in cognitive function with increasing chronological age (Marriott and Abelson, 1980;Grotewiel et al, 2005;Mell et al, 2005;Murakami and Murakami, 2005;Yu et al, 2006;Soei and Daum, 2008;Woodruff-Pak et al, 2008). In contrast to most animal species, honeybees normally show a strong relationship between chronological age and social role.…”

Section: Introductionmentioning

confidence: 99%

Impaired tactile learning is related to social role in honeybees

Scheiner

Amdam

2009

Journal of Experimental Biology

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SUMMARYAging is commonly accompanied by a decline in cognitive functions such as learning and memory. In social insects, aging is tightly linked to social role. The honeybee (Apis mellifera L.) offers the unique opportunity to separate chronological age from social role. In the present paper, we tested whether chronological age, social role and the duration of performing this role affect tactile learning in honeybees. We compared acquisition, retention and discrimination between foragers with short and long foraging durations and age-matched nurse bees. Our data show that chronological age is of minor importance for tactile learning, retention and discrimination whereas social role has a decisive impact. Tactile acquisition is severely impaired in bees that have foraged for more than two weeks but not in nurse bees of the same chronological age. Interestingly, neither discrimination nor retention appear to be impaired by long foraging duration. The complex associations between acquisition, discrimination and retention in bees of different social roles open up rich possibilities for future studies on the neuronal correlates of behavioural performance and underline that the honeybee has great potential as a model system in the biology of aging.

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Effects of paradigm and inter-stimulus interval on age differences in eyeblink classical conditioning in rabbits

Cited by 11 publications

References 63 publications

Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice

Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

Impaired tactile learning is related to social role in honeybees

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