Effects of Papaverine on Twitches in Mouse Diaphragm

Kaneda, Toshio; Hayasaka, Ryutaro; Nagai, Yuta; Tajima, Tsuyoshi; Urakawa, Norimoto; Nakajyo, Shinjiro; Shimizu, Kazumasa

doi:10.1159/000320769

Cited by 3 publications

(2 citation statements)

References 79 publications

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“…Papaverine hydrochloride is a spasmolytic drug which can be found in opium as its main isoquinoline alkaloid. It is used in bile, intestinal, and renal spikes [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients

et al. 2014

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The influence of excipients on the disintegration times of tablets and the release of papaverine hydrochloride (PAP) from tablets were studied. Ten different formulations of tablets with PAP were prepared by direct powder compression. Different binders, disintegrants, fillers, and lubricants were used as excipients. The release of PAP was carried out in the paddle apparatus using 0.1 N HCl as a dissolution medium. The results of the disintegration times of tablets showed that six formulations can be classified as fast dissolving tablets (FDT). FDT formulations contained Avicel PH 101, Avicel PH 102, mannitol, (3-lactose, PVP K 10, gelatinized starch (CPharmGel), Prosolv Easy Tab, Prosolv SMCC 90, magnesium stearate, and the addition of disintegrants such as AcDiSol and Kollidon CL. Drug release kinetics were estimated by the zero- and first-order, Higuchi release rate, and Korsmeyer-Peppas models. Two formulations of the tablets containing PVP (K10) (10%), CPharmGel (10% and 25%), and Prosolv Easy Tab (44% and 60%) without the addition of a disintegrant were well-fitted to the kinetics models such as the Higuchi and zero-order, which are suitable for controlled- or sustained-release.

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“…Papaverine hydrochloride is a spasmolytic drug which can be found in opium as its main isoquinoline alkaloid. It is used in bile, intestinal, and renal spikes [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients

et al. 2014

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“…It is a spasmolytic drug, which inhibits phosphodiesterase resulting in a smooth muscle relaxant. Therefore it most often used in gastrointestinal disorders, bile, intestinal and renal spikes [13,14].…”

Section: Original Papersmentioning

confidence: 99%

Influence of Polymer Type on the Physical Properties and Release Profile of Papaverine Hydrochloride From Hard Gelatin Capsules

et al. 2016

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Is the Phoenix Sign Phenomenon Due to Vasodilation? A Double-Blinded, Randomized Controlled Trial Comparing Motor Function Recovery After Diagnostic Common Fibular Nerve Block with Lidocaine and Papaverine

Barrett,

Boyd,

DuCasse

et al. 2024

Preprint

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Background Focal entrapment of the common fibular (peroneal) nerve (CFN) is the most common nerve entrapment in the lower extremity. Accurate diagnosis can be difficult due to co-existent pathology such as low back pathology. A 1% lidocaine block of CFN is often used to confirm the local entrapment pathology and demonstrate possibility of pain relief. A surprising, unexpected and temporary strengthening of CFN supplied ankle and foot muscles is occasionally produced, termed the Phoenix sign. Aetiology of this phenomenon has been puzzling, but restoration of neural circulation and nutrition via improved local blood flow has been postulated to be responsible. Methods This is a double-blinded, randomized, prospective controlled trial of 19 patients, comparing 2 vasodilating agents and their ability to produce the Phoenix effect. Ultrasound guided infiltration of 0.3 mL 1% lidocaine or papaverine HCl 10 mg/mL was executed adjacent to CFN. Motor strength pre- infiltration and 4 minutes post-infiltration were measured for anterior compartment muscles utilizing MRC manual motor testing reported on a 0–5 scale. The extensor hallucis longus (EHL) muscle proved to be the most significant. Results Average motor strength of the EHL improved from 2.2 (+/-0.40) to 4.9 (+/-0.32).) in the lidocaine group. In the papaverine group, pre-infiltration EHL motor strength averaging 2.1 (+/-0.93) improved to 4.4 (+/- 1.01) post-infiltration. Papaverine and lidocaine produced similar statistically significant increases in muscle strength (p = < 0.05). Conclusion There was no difference between small local infiltrations of lidocaine or papaverine in production of increased anterior compartment EHL motor strength. It is most likely that the Phoenix Effect is explained by temporary local improvements in the microcirculation of the CFN vasa nervorum.

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Effects of Papaverine on Twitches in Mouse Diaphragm

Cited by 3 publications

References 79 publications

Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients

Release Kinetics of Papaverine Hydrochloride from Tablets with Different Excipients

Influence of Polymer Type on the Physical Properties and Release Profile of Papaverine Hydrochloride From Hard Gelatin Capsules

Is the Phoenix Sign Phenomenon Due to Vasodilation? A Double-Blinded, Randomized Controlled Trial Comparing Motor Function Recovery After Diagnostic Common Fibular Nerve Block with Lidocaine and Papaverine

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