Effects of palonosetron and dexamethasone on postoperative nausea and vomiting in adult patients undergoing laparoscopic abdominal surgery: a randomized, double-blind, clinical trial at a tertiary care hospital

Tahir, Sifna; Mir, Altaf Ahmad; Hameed, Abdul

doi:10.18203/2349-3933.ijam20163747

Cited by 2 publications

(1 citation statement)

References 18 publications

(22 reference statements)

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“…It decreases levels of 5-HT3 in neural tissue and in the gut and is commonly used as an antiemetic agent in cancer chemotherapy and PONV. It has Tahir et al 11 also reported a significantly higher frequency of nausea in group D (dexamethasone) as compared to group P (palonosetron), while the frequency of vomiting was comparable between the two groups from 0 to 6 hours postoperatively. From 6 to 48 hours, however, the frequency of nausea and vomiting was found comparable between the two groups, in contrast to our findings.…”

Section: Materials a N D Methodsmentioning

confidence: 86%

Frequency of Postoperative Nausea and Vomiting after General Anesthesia in a Tertiary Care Hospital: A Comparison of Palonosetron and Dexamethasone

Kumari¹,

Kaur²,

Nagi³

2021

AMEI's Current Trends in Diagnosis &Amp; Treatment

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Introduction: Postoperative nausea and vomiting (PONV) is an unpleasant sensation often described as worse than postoperative pain. Various drugs, including scopolamine, gabapentin, dexamethasone, metoclopramide, promethazine, haloperidol, and serotonin receptor antagonists, have been used for prophylaxis of PONV, but none has been 100% efficacious. We hereby try to compare the effects of palonosetron and dexamethasone on the frequency of PONV. Aims and objectives: The aim of our study was to compare the frequency of PONV with palonosetron and dexamethasone in patients undergoing elective laparoscopic cholecystectomy surgery under general anesthesia. Material and methods: In this prospective, randomized, double-blind study, 50 patients scheduled for laparoscopic cholecystectomy were randomized into two groups receiving 8 mg dexamethasone or 0.075 mg palonosetron. The frequency of PONV in the two groups was compared. Results: Statistical analysis was done using SPSS version 20 (SPSS Inc., Chicago, Illinois, USA).The patients in the two groups were comparable in terms of mean age, body mass index, and gender distribution. At 4, 8, and 12 hours, the incidence of PONV was significantly less in patients receiving palonosetron than those receiving dexamethasone (p = 0.007, 0.001, 0.001, respectively). Conclusion:We can conclude from the present study that 0.075 mg palonosetron is more effective than 8 mg dexamethasone to reduce the incidence of PONV after laparoscopic cholecystectomy.

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Section: Materials a N D Methodsmentioning

confidence: 86%

Frequency of Postoperative Nausea and Vomiting after General Anesthesia in a Tertiary Care Hospital: A Comparison of Palonosetron and Dexamethasone

Kumari¹,

Kaur²,

Nagi³

2021

AMEI's Current Trends in Diagnosis &Amp; Treatment

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Comparison of Effectiveness Among Ondansetron, Palonosetron And Granisetron in Preventing Postoperative Nauseaand Vomiting Following Laparoscopic Cholecystectomy

Ghosh

Mazumdar

Sarkar

et al. 2021

ijsr

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Postoperative nausea and vomiting (PONV) has been variously described as the “big little problem” the “nal therapeutic challenge” for anaesthesiology. The commonest cause of morbidity after anaesthesia and surgery are pain and postoperative nausea vomiting 1. To compare the incidences of PONV following laparoscopic cholecyetectomy in different groups of patients receiving ondansetron, palonosetron and Granisetron. 2. To identify the better strategy for prevention of PONV. This is a prospective randomized double blinded clinical study. Both patient and observer were blinded to the group allocation. Allocations to three groups were strictly condential and concealed. One and half year (18 months). Patients undergoing elective laparoscopic cholecystectomy under General Anaesthesia at General Surgery operation theatres of Bankura Sammilani Medical College and Hospital, Bankura The effects of palonosetron, granisetron and ondansetron in preventing PONV (postoperative nausea vomiting) were compared in patients undergoing laparoscopic cholecystectomy and it was found that palonosetron was best and granisetron better in comparison with ondansetron in preventing postoperative nausea and vomiting. Palonosetron provides more effective prophylaxis of early PON (postoperative nausea), late PON (postoperative nausea), and late POV (postoperative vomiting) compared with granisetron and ondansetron. Palonosetron could provide effective prophylactic antiemetic control to prevent PONVafter laparoscopic cholecystectomy surgery under general anesthesia.

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Effects of palonosetron and dexamethasone on postoperative nausea and vomiting in adult patients undergoing laparoscopic abdominal surgery: a randomized, double-blind, clinical trial at a tertiary care hospital

Cited by 2 publications

References 18 publications

Frequency of Postoperative Nausea and Vomiting after General Anesthesia in a Tertiary Care Hospital: A Comparison of Palonosetron and Dexamethasone

Frequency of Postoperative Nausea and Vomiting after General Anesthesia in a Tertiary Care Hospital: A Comparison of Palonosetron and Dexamethasone

Comparison of Effectiveness Among Ondansetron, Palonosetron And Granisetron in Preventing Postoperative Nauseaand Vomiting Following Laparoscopic Cholecystectomy

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