Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia–reperfusion

Ajamieh, Hussam; Menéndez, Silvia; Martı́nez-Sánchez, Gregorio; Candelario‐Jalil, Eduardo; Re, Lamberto; Giuliani, Attilia; Fernández, Olga

doi:10.1111/j.1478-3231.2004.00885.x

Cited by 104 publications

(95 citation statements)

References 37 publications

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“…Additionally, ischemia leads to excitotoxicity mediated by glutamate receptor activation and the subsequent increase of nitric oxide and calcium accumulation, resulting in a damage of the pump systems and serious disturbances in ionic conductance which are associated with apoptosis and necrosis of neurons [22] and white matter injury [23]. Ozone therapy could regulate these mediators and reduce the pathological oxidative stress, as demonstrated in liver [3] and renal [4] rat models.…”

Section: Disclosure Statementmentioning

confidence: 99%

“…Within this context, other interesting actions of ozone therapy have been described: improvement in vascular rheology [5,6], increase in blood flow in the carotid and middle cerebral arteries [7], improvement in tissue oxygenation in hypoxic tissues [8,9], enhancement of antioxidant systems, and modulation of immune/inflammatory response [2][3][4]. More Literatur…”

Section: Disclosure Statementmentioning

confidence: 99%

“…It has been described that ozone can enhance antioxidant systems and regulate immune/inflammatory response [2][3][4], improve vascular rheology [5][6][7], and increase blood flow in carotid and middle cerebral arteries [8] and tissue oxygenation in hypoxic tissues [9]. We have previously treated several ischemic syndromes [10] and radiation-induced side effects [11,12] with this procedure.…”

Section: Introductionmentioning

confidence: 99%

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Brain Ischemia and Hypometabolism Treated by Ozone Therapy

Clavo

Suárez

Aguilar

et al. 2011

Forsch Komplementmed

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Background: Radiation-induced brain injury (RBI) and low-perfusion brain syndromes are mediated by ischemia and hypometabolism and have limited treatment options. Ozone therapy as treatment in vascular diseases has been described, but the effects on brain tissue have not been well documented. Case Report: We describe a 75-year-old patient with vascular risk factors and meningioma who was treated with stereotactic radiosurgery. 14 months later the patient presented with progressive clinical impairment despite the use of acetylsalicylic acid and corticosteroids. Clinical and imaging evaluations before/after ozone therapy were done by magnetic resonance imaging (MRI), computed tomography (CT), single photon emission computed tomography (SPECT), and positron emission tomography (PET); performance status assessment was done using Barthel Index and World Health Organization/Eastern Cooperative Oncology Group Scale (WHO/ECOG Scale). Ozone therapy was performed by autohemotransfusion. Results: Basal images showed brain areas with ischemia and hypometabolism compatible with ischemic processes and/or RBI. There were no changes in MRI or CT scan images following ozone therapy. However, improvements in brain perfusion and metabolism were demonstrable with SPECT and PET; they correlated with clinical development and performance status scales. Conclusion: This report supports our previous works about the effect of ozone therapy in cerebral blood flow, and it suggests the use of ozone therapy in ischemic and hypometabolic brain syndromes such as stroke or RBI.

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Section: Disclosure Statementmentioning

confidence: 99%

Section: Disclosure Statementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Ischemia and Hypometabolism Treated by Ozone Therapy

Clavo

Suárez

Aguilar

et al. 2011

Forsch Komplementmed

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“…La inhalación de oxigeno + ozono por 10 o 15 días produce pre-acondicionamiento al estrés oxidativo por ozono y protege al hígado del daño por isquemia y reperfusión, que se ha explicado por aumento de la expresión de enzimas antioxidantes (superóxido dismutasa, catalasa y glutatión peroxidasa), que probablemente gatillen el pre-acondicionamiento oxidativo por ozono [36][37][38] . Por otra parte, en simulaciones de shock endotóxico, el ozono protege a la rata disminuyendo TNF-α sanguíneo, esto se explicaría porque los antioxidantes generados por el ozono, administrado antes de la lesión, disminuyen el NF-kB y las citoquinas circulantes 39,40 .…”

Section: Discussionunclassified

Efecto del sulfato de cobre en el daño pulmonar inducido por la exposición crónica intermitente a ozono

et al. 2017

Rev. méd. Chile

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Effect of copper sulphate on the lung damage induced by chronic intermittent exposure to ozone count, proteins, GGT and AP in BALF (p < 0.05). Foamy and pigmented alveolar macrophages were detected in all lungs of these animals (p < 0.001). Conclusions: Intratracheal instillation of a single dose of CuSO 4 in rats previously subjected to a chronic and intermittent exposure to ozone induces a neutrophil pulmonary inflammatory response and cytoplasmic damage in macrophages. (Rev Med Chile 2017; 145: 9-16)

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“…Numerosos autores han trabajado a nivel preclínico sobre los efectos de la ozonoterapia sobre los organismos vivos, pudiéndose demostrar efectos beneficiosos sobre la capacidad antioxidante celular y la adaptación ante los procesos de isquemia/reperfusión (3)(4)(5)(6)(7).…”

Section: Introductionunclassified

Ozonoterapia en medicina del dolor: revisión

Hidalgo-Tallón

Torres

2013

Rev. Soc. Esp. Dolor

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Increasingly more medical ozone is used in the treatment of pain. So much so that recently the Spanish Ministry of Health has included ozone therapy in the portfolio of pain units.The effectiveness, safety and good tolerability of ozone, in ltrated as well as administered systemically, justify the extent of its use in recent years.Because little is known in general on this subject, the aim of this revision is to update current knowledge about ozone therapy in pain medicine.Key words: Ozone. Medical ozone. Pain medicine. RESUMENCada vez se emplea más el ozono médico en el tratamiento del dolor. Tanto es así que recientemente el Ministerio de Sanidad español ha incluido la ozonoterapia en la cartera de servicios de las unidades de dolor.La efectividad, seguridad y buena tolerabilidad del ozono, tanto in ltrado como administrado por vía sistémica, justi can la extensión de su uso en los últimos años.Debido al escaso conocimiento que en general hay acerca del tema, pretendemos, con esta revisión, poner al día los conocimientos actuales en torno a la ozonoterapia en medicina del dolor.Palabras clave: Ozonoterapia. Ozono médico. Medicina del dolor. INTRODUCCIÓNLa ozonoterapia en medicina es una realidad, y cada vez hay más profesionales haciendo uso del ozono médico como complemento terapéutico para diferentes enfermedades relacionadas con el estrés oxidativo, incluido el dolor crónico.Ya existe una organización médica en torno a la ozonoterapia, y hay asociaciones profesionales que garantizan la buena praxis, y se enseña la ozonoterapia en másteres y cursos de experto de diversas universidades (Curso de experto universitario en ozonoterapia, Universidad de Sevilla, www.aepromo.org, www.seot.es, www.aceoot. org).Se calcula que en el mundo hay más de 26.000 médicos expertos en ozonoterapia, y en Europa son tratados anualmente en torno a los 10 millones de pacientes (1).Recientemente, el Ministerio de Sanidad español ha incluido la ozonoterapia en la cartera de servicios de las unidades de dolor, por lo que se hace necesario que el médi-co experto en el tratamiento del dolor conozca el fundamento científico de la ozonoterapia médica y cómo actúa, tanto a nivel local como sistémico.El ozono es una molécula formada por tres átomos de oxígeno (O 3 ) en lugar de los dos de los que se compone la molécula de oxígeno (O 2 ). La ozonoterapia consiste en la aplicación de una mezcla de oxígeno médico con ozono; la mezcla ha de ser producida in situ para cada aplicación, y en ella nunca habrá más de un 5 % de ozono. REVISIONES MBA

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Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia–reperfusion

Cited by 104 publications

References 37 publications

Brain Ischemia and Hypometabolism Treated by Ozone Therapy

Brain Ischemia and Hypometabolism Treated by Ozone Therapy

Efecto del sulfato de cobre en el daño pulmonar inducido por la exposición crónica intermitente a ozono

Ozonoterapia en medicina del dolor: revisión

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