Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

Ferland, Chantelle L.; Reichel, Carmela M.; McGinty, Jacqueline F.

doi:10.1007/s00213-015-4184-7

Cited by 32 publications

(17 citation statements)

References 55 publications

(74 reference statements)

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“…In animal studies, oxytocin supplementations have also been found to successfully attenuate the observed negative emotional consequences of opioid withdrawal (Zanos et al, 2014). Similar results have been reported for cocaine (Georgiou et al 2014), amphetamines (Ferland, Reichel, & McGinty, 2016), cannabis (McRae-Clark, Baker, Maria, & Brady, 2013), tobacco (Manbeck, Shelley, Schmidt, & Harris, 2014), and alcohol (Peters, Bowen, Bohrer, & McGregor, 2016). In rats, oxytocin supplementations during adolescence have been found to reduce alcohol intake (Bowen et al, 2011) and amphetamine consumption at adult age (Hicks, Cornish, Baracz, Suraev, & McGregor, 2016).…”

Section: Use In College Studentssupporting

confidence: 58%

Mummy, Daddy, and Addiction: Implicit Insecure Attachment is Associated with Substance Use in College Students

Serra¹,

Chatard²,

Tello³

et al. 2019

Preprint

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Indirect measures of cognition have become an important tool in research on addiction. To date, however, no research has examined whether indirect measures of parent attachment relate to substance use. To examine this issue, a sample of college students (N = 121) was asked to complete two measures of explicit attachment (the Relationship Questionnaire; Bartholomew & Horowitz, 1991, and the Adult Attachment Styles; Collins & Read, 1990), and a measure of implicit attachment (the Single Category Implicit Association Test, Karpinski & Steinman, 2006). The indirect attachment measure assessed the strength of automatic mental association between the concepts parents and secure. Participants also completed different measures of tobacco, cannabis, and alcohol use. Results showed that, for most of the participants, the parents were considered a source of security at both the explicit and implicit levels. Direct and indirect attachment measures were not related to each other. Overall, explicit attachment was not related to substance use. However, implicit attachment was significantly associated with the use of licit (tobacco) and illicit (cannabis) drugs. We also found some evidence that polydrug use is especially common among students with an insecure implicit attachment. This is the first study to examine how implicit attachment processes relate to addictive behaviors. The results suggest that implicit attachment, thought to reflect unconscious traces of past experiences, is a better predictor of substance use in college students than direct, self-reported measures of attachment. Further studies should examine whether implicit attachment is associated with severe substance use disorders in clinical populations.

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Section: Use In College Studentssupporting

confidence: 58%

Mummy, Daddy, and Addiction: Implicit Insecure Attachment is Associated with Substance Use in College Students

Serra¹,

Chatard²,

Tello³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…An acute injection of oxytocin given before reinstatement testing was sufficient to attenuate meth seeking in both conditions. As well, in a separate experiment, repeated oxytocin doses following TMT pre-exposure but prior to self-administration training blocked TMT-induced reinstatement, suggesting a protective effect of oxytocin administration on future meth-seeking behavior (Ferland et al, 2016; Hicks et al, 2016). Centrally administered oxytocin (0.1, 0.5, and 2.5μg; icv) reduced the effect of restraint stress on reinstatement of meth CPP but did not block meth-primed CPP (Qi et al, 2009).…”

Section: Oxytocin Effects On Preclinical Models Of Addictionmentioning

confidence: 76%

“…Systemic oxytocin administered before yohimbine prevented reinstatement (Cox, Young, et al, 2013). Oxytocin also decreased reinstatement in response to an ethologically-relevant predator odor (trimethylthiazoline; TMT) (Ferland, Reichel, & McGinty, 2016). Male rats underwent exposure to TMT (or a neutral odor) in locomotor chambers for 5days before self-administration training.…”

Section: Oxytocin Effects On Preclinical Models Of Addictionmentioning

confidence: 99%

Oxytocin and Rodent Models of Addiction

Leong

Cox

King

et al. 2018

International Review of Neurobiology

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Interest for the use of oxytocin as a treatment for addiction began over 40years ago. Better known for its roles in parturition, lactation and pair bonding, oxytocin also has anxiolytic properties, reduces immune and inflammatory responses, and has a role in learning and memory. In this chapter, oxytocin effects on addiction processes are described by highlighting research findings that have used oxytocin within current preclinical animal models of addiction, relapse, or craving. First, we provide a brief background of the endogenous oxytocin system followed by descriptions of the behavioral models used to study addiction, including models of drug taking and seeking. Then we review recent preclinical studies that have used oxytocin as a therapeutic intervention throughout multiple stages of the addiction cycle from a behavioral and neurobiological perspective. These models encompass the entire range of the addiction cycle including acquisition and maintenance of drug taking, withdrawal and craving during periods of drug abstinence, and ultimately relapse. We then posit several theories about how oxytocin interacts with both drug and social reward, as well as presenting a mechanistic account of how specific oxytocin receptor localization may contribute to oxytocin's efficacy as an addiction therapeutic.

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“…An extensive literature explores interactions between stress and cocaine addiction and several recent papers find long-term increases in drug-seeking after an acute stressor 77 – 79 . However, this is the first study to separate stress-resilient from susceptible rats to find that cocaine seeking is altered by the presence (and absence) of TMT-induced anxiety.…”

Section: Discussionmentioning

confidence: 99%

A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors

et al. 2018

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PTSD is highly comorbid with cocaine use disorder (CUD), and cocaine users with PTSD + CUD are more resistant to treatment. Here we sought to develop a rat model of PTSD + CUD in order to identify the neurobiological changes underlying such comorbidity and screen potential medications for reducing cocaine seeking in the PTSD population. We utilized a predator scent stress model of PTSD, wherein rats received a single exposure to the fox pheromone 2,5-dihydro-2,4,5-trimethylthiazoline (TMT). One week after TMT exposure, stress-susceptible (susceptible), intermediate, and resilient phenotypes were detected and were consistent with behavioral, corticosterone, and gene expression profiles 3 weeks post TMT. We assessed phenotypic differences in cocaine self-administration, extinction, and cue-primed reinstatement. Susceptible rats exhibited deficits in extinction learning and increased cue-primed reinstatement that was not prevented by Ceftriaxone, an antibiotic that consistently attenuates the reinstatement of cocaine seeking. TMT-exposed resilient rats displayed increased mGlu5 gene expression in the amygdala and medial prefrontal cortex and did not display the enhanced cocaine seeking observed in susceptible rats. Combined treatment with the mGlu5 positive allosteric modulator 3-Cyano-N-(1,3-diphenyl-1 H-pyrazol-5-yl)benzamide (CDPPB), fear extinction, and ceftriaxone prevented the reinstatement of cocaine seeking in susceptible rats with fear extinction an important mediating condition. These results highlight the need for animal models of PTSD to consider stress-responsivity, as only a subset of trauma-exposed individuals develop PTSD and these individuals likely exhibit distinct neurobiological changes compared with trauma-exposed populations who are resilient to stress. This work further identifies glutamate homeostasis and mGlu5 as a target for treating relapse in comorbid PTSD-cocaine addiction.

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Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats

Cited by 32 publications

References 55 publications

Mummy, Daddy, and Addiction: Implicit Insecure Attachment is Associated with Substance Use in College Students

Mummy, Daddy, and Addiction: Implicit Insecure Attachment is Associated with Substance Use in College Students

Oxytocin and Rodent Models of Addiction

A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors

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