Effects of oxygen on the response of mitochondria to X-irradiation and reactive oxygen species-mediated fibroblast activation

Composite hydrogels with antioxidant and robust adhesive properties for the prevention of radiation-induced dermatitis

“…58,59 However, when ionizing radiation acts on skin tissue during radiotherapy, it will promote the decomposition of water molecules in the tissue and produce a large amount of ROS, which will cause mitochondrial dysfunction and lead to persistent oxidative stress, so as to seriously damage the function and vitality of basal cells, and ultimately lead to skin damage. 60–62 Consequently, products with antioxidant activity can remove excess ROS produced during the radiation process, reducing or eliminating further damage to the body. Compared with SP, SPM doped with MoS 2 nanosheets to endow the hydrogel with good antioxidant activity, which can remove excessive ROS generated by radiation and alleviate oxidative stress, thus avoiding radiation-induced skin damage.…”

“…58,59 However, when ionizing radiation acts on skin tissue during radiotherapy, it will promote the decomposition of water molecules in the tissue and produce a large amount of ROS, which will cause mitochondrial dysfunction and lead to persistent oxidative stress, so as to seriously damage the function and vitality of basal cells, and ultimately lead to skin damage. [60][61][62] Fig. 6 In vivo biosafety study of hydrogels.…”

Mitochondrial Signaling Pathways Associated with DNA Damage Responses

“…Figure 2 depicts the damaged nucleus to mitochondria signaling. DNA damage signals are transported to mitochondria by the adenosine monophosphate (AMP)-activated protein kinase (AMPK) [ 38 , 39 ]. ATM-mediated AMPK signaling is currently being investigated because ATM has been shown not to directly phosphorylate AMPK [ 40 ].…”