Effects of oxygen inhalation on skin microcirculation in patients with peripheral arterial occlusive disease.

Bongard, O; Bounameaux, Henri; Fagrell, B

doi:10.1161/01.cir.86.3.878

Cited by 55 publications

(46 citation statements)

References 26 publications

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“…LDF is an index of total skin microcirculation rather than nutritional circulation [32,33]. It was not surprising, therefore, that there was no significant change in LDF under any of the testing conditions from baseline to 3 weeks in our 14 patients, and that the values of LDF were scattered over a wide range.…”

Section: Ldfmentioning

confidence: 71%

Acute and Long-Term Effects of Prostaglandin E<sub>1</sub> Assessed by Clinical and Microcirculatory Parameters in Critical Limb Ischemia: A Pilot Study

Stricker

Kaiser²,

Frei³

et al. 1996

Int J Microcirc

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We treated 14 patients suffering from critical limb ischemia (CLI) as defined by the Consensus Document, and in whom possibilities of surgical or percutaneous arterial reconstruction were excluded, by PGE₁ 60 µg i.v. daily during 3 weeks. Effects were evaluated by clinical, macrocirculatory and microcirculatory parameters during a follow-up of 1 year. After treatment with PGE₁·, we noted a significant reduction in analgesic use and in pain score. The average tcpO₂ values on the forefoot in the supine and sitting positions, with or without inhalation of O₂ through a face mask, showed a significant improvement after 3 weeks, as well as capillary stage. Laser Doppler flux did not change, but was significantly higher in diabetic patients than in nondiabetics with CLI. In 4 patients (28%) no improvement could be found after 3 weeks’ treatment. Although in 6 patients the improvement lasted for up to 4 months, the legs eventually deteriorated. In 4 patients (28%) the legs were preserved after 1 year without further active therapy. No patient with initial tcpO₂ values above 40 mm Hg in the supine and 100 mm Hg in the sitting positions during O₂ inhalation lost a leg. Although other effects like local care could have influenced the outcome favorably, we noticed a beneficial albeit transient effect of PGE₁ for the majority of our patients with CLI. TcpO₂ measurements with O₂ inhalation might be a valuable predictor of a positive long-term result.

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Section: Ldfmentioning

confidence: 71%

Acute and Long-Term Effects of Prostaglandin E<sub>1</sub> Assessed by Clinical and Microcirculatory Parameters in Critical Limb Ischemia: A Pilot Study

Stricker

Kaiser²,

Frei³

et al. 1996

Int J Microcirc

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“…The vidcodensitometric signals of the windows arc cross-correlated, and the interwindow transit times for similar signals are determined. With a known interwindow distance, the CBV can be continuously calculated and displayed on the computer screen [11][12][13]. Cross-correlation coefficients of r >0.95 were regarded as acceptable, otherwise measurements of CBV were repeated.…”

Section: Microcirculation: Morphology and Dynamicsmentioning

confidence: 99%

Impaired Microcirculation in Heart Failure

et al. 1996

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The aim of the present study was to examine the nailfold capillary morphology and dynamics in treated chronic heart failure (CHF) in relation to parameters of left ventricular structure and function. Twenty patients with CHF class II according to the New York Heart Association underwent a capillaroscopic examination at the finger nailfold using a computerized videophotometric system (Capiflow®) at rest and after 1 min arterial occlusion. Study parameters ere number, length and diameter of the capillaries as well as capillary blood velocity (CBV). Further experiments included echocardiography and determination of left ventricular ejection fraction by Tc scintigraphy. Nailfold capillaries in established CHF are enlarged and the CBV is dramatically decreased. The reactive hyperemic response to 1 min arterial occlusion is attenuated. CBV correlates positively with left ventricular ejection fraction (r = 0.61, p = 0.01) and inversely with left ventricular end-diastolic (r = -0.56, p = 0.04) and end-systolic (r = -0.69, p = 0.01) diameters. The time-to-peak flow after 1 min arterial occlusion is positively related (r = 0.68, p < 0.05) to the duration of CHF. Our data indicate that finger microcirculation in CHF deteriorates as a function of the severity and duration of heart failure.

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“…Oxygen is delivered to the tissue from skin microvessels, so transcutaneous measurements of oxygen pressure (tcP # ) give an approximate indication of oxygenation by the skin-specific microcirculation. The technique gives an important index in the evaluation of, for example, skin ischaemia [13].…”

Section: Transcutaneous Po # Measurementsmentioning

confidence: 99%

“…Microcirculatory methods allow a more accurate prognosis in patients with severe arterial insufficiency [3,13], and the effects of different treatment modalities can be better evaluated [3].…”

Section: Peripheral Arterial Obliterative Diseasementioning

confidence: 99%

See 1 more Smart Citation

Microcirculation: its significance in clinical and molecular medicine

Fagrell

Intaglietta

1997

Journal of Internal Medicine

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Effects of oxygen inhalation on skin microcirculation in patients with peripheral arterial occlusive disease.

Abstract: Inhalation of 40% oxygen induces a vasoconstriction in the skin microcirculation of toes of the normal subjects and patients with moderate PAOD but induces an increase of the skin microcirculation in patients with severe PAOD.

Cited by 55 publications

References 26 publications

Acute and Long-Term Effects of Prostaglandin E<sub>1</sub> Assessed by Clinical and Microcirculatory Parameters in Critical Limb Ischemia: A Pilot Study

Acute and Long-Term Effects of Prostaglandin E<sub>1</sub> Assessed by Clinical and Microcirculatory Parameters in Critical Limb Ischemia: A Pilot Study

Impaired Microcirculation in Heart Failure

Microcirculation: its significance in clinical and molecular medicine

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