Effects of oxygen generating scaffolds on cell survival and functional recovery following acute spinal cord injury in rats

Liu, Liangle; Wan, Junming; Dai, Minghai; Ye, Xiuzhi; Chun, Liu; Tang, Chengxuan; Zhu, Lixin

doi:10.1007/s10856-020-06453-y

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…The implantation of biomaterials alone already holds the potential to support the ingrowth of blood vessels into the lesion site. This angiogenic potential was shown using many different biomaterials, such as a reduced graphene oxide scaffold [ 74 ], an oxygen-generating hydrogel scaffold [ 75 , 76 ], a nanofiber-hydrogel composite [ 77 ], “NeuroGel” [ 78 ], an aligned fibrin hydrogel [ 79 ], and a collagen type I scaffold [ 80 ] ( Fig. 4E ).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study reports an increased blood vessel density after the implantation of a nanofiber-hydrogel composite 3 days after injury [ 77 ]. Biomaterials are mostly applied at the injury site as scaffolds replacing the lesion after implantation [ 32 , 34 , 38 , 40 , 43 , 44 , 47 , 69 , 73 , 74 , 78 , 80 , 83 - 90 , 92 - 94 , 96 - 105 ] or injection[ 33 , 75 , 77 , 82 , 95 ] with only a few hydrogels being implanted on top of the injured spinal cord [ 30 , 39 , 91 ] or injected systemically [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

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Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

et al. 2022

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Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functional integrity of the microvasculature to prevent neural loss and to promote neural repair is an important challenge and opportunity in SCI research. Herein, we summarize the course of vascular injury and repair following SCI and give a comprehensive overview of current experimental therapeutic approaches targeting spinal cord microvasculature to diminish ischemia and thereby facilitate neural repair and regeneration. A systematic review of the published literature on therapeutic approaches to promote vascular repair after experimental SCI was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) standards. The MEDLINE databases PubMed, Embase, and OVID MEDLINE were searched using the keywords “spinal cord injury,” “angiogenesis,” “angiogenesis inducing agents,” “tissue engineering,” and “rodent subjects.” A total of 111 studies were identified through the search. Five main therapeutic approaches to diminish hypoxia-ischemia and promote vascular repair were identified as (1) the application of angiogenic factors, (2) genetic engineering, (3) physical stimulation, (4) cell transplantation, and (5) biomaterials carrying various factor delivery. There are different therapeutic approaches with the potential to diminish hypoxia-ischemia and promote vascular repair after experimental SCI. Of note, combinatorial approaches using implanted biomaterials and angiogenic factor delivery appear promising for clinical translation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

et al. 2022

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“…In the early stage of tissue injury, hypoxia is unfavorable for tissue regeneration, especially in a poorly vascularized microenvironment, which generally induces oxidative stress, apoptosis and necrosis, thereby accelerating cell death [ 46 ]. In recent years, the issue of local hypoxia in skin healing, bone regeneration and nerve repair has gained increasing attention, and studies have clarified the beneficial effects of local oxygen supply on tissue regeneration and repair [ [47] , [48] , [49] , [50] ]. However, the effect of local oxygen supply on tissue regeneration during the AF repair is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Zheng

Xue

Wei

et al. 2023

Materials Today Bio

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Biomaterial‐Based Defenders Boost Biopharmaceuticals Efficacy for Spinal Cord Injury Treatment: A Review

Zhang

Cao

2023

Adv Materials Inter

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Spinal cord injury (SCI) has seriously affected the lives of patients and brought economic and medical burdens to society. Biopharmaceuticals, including transplanted cells, growth factors, enzyme drugs, and microRNA, present multidimensional therapeutic effects in tissue repair and regeneration, and thus are widely utilized for the treatment of SCI. Nevertheless, they still encounter great challenges. The turbulent microenvironment accompanied by various destructive components following SCI has led to poor stability, low local accumulation, and reduced therapeutic efficacy of biopharmaceuticals. To this end, biomaterial‐based defenders (BBDs) that are capable of resisting the destructive components have shown great promise in improving the survival of transplanted cells or retaining the activity of the protein and nucleic acid drugs for the treatment of SCI. In this review, various types of biopharmaceuticals applied in SCI and their limitations are introduced. The destructive components that threaten the activities of biopharmaceuticals in the rigorous microenvironment are then summarized. In particular, the current research progress about BBDs boosting the efficacy of biopharmaceuticals for the treatment of SCI is illustrated with specific examples. The existing challenges and future perspectives are also provided.

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Effects of oxygen generating scaffolds on cell survival and functional recovery following acute spinal cord injury in rats

Cited by 5 publications

References 44 publications

Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats

Biomaterial‐Based Defenders Boost Biopharmaceuticals Efficacy for Spinal Cord Injury Treatment: A Review

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