Effects of Oxygen at Increased Pressure

Bean, James C.

doi:10.1152/physrev.1945.25.1.1

Cited by 250 publications

(38 citation statements)

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“…14,35 The oxygen diffusion distance from the perfused capillaries is increased approximately fourfold with HBO administration. 36 HBO therapy can increase arterial oxygen tensions to 2,000 mm Hg and achieves partial pressure of oxygen in tissues in the order of 500 mm Hg. 37 Tissue oxygenation is increased to levels that are sufficient to support resting tissues without a contribution from hemoglobin, resulting in a reversal in hypoxia for the duration of the treatment and for a significant time following therapy.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

Nikfarjam

Cuthbertson

Malcontenti‐Wilson

et al. 2007

Journal of Gastrointestinal Surgery

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Severe acute pancreatitis is characterized by pancreatic necrosis, resulting in local and systemic inflammation. Hyperbaric oxygen (HBO) therapy modulates inflammation, but has not been extensively studied in pancreatitis. This study investigates the effects of HBO in a rat model of severe acute pancreatitis. Sixty-four rats were induced with severe pancreatitis using 4% sodium taurocholate and randomized to HBO treatment or control. HBO was commenced 6 h after induction (100% oxygen at 2.5 atmospheres for 90 min) and continued every 12 h for a maximum of eight treatment episodes. Surviving animals were killed at 7 days. Severity of pancreatitis was graded macroscopically and microscopically. Lung edema was calculated using wet and dry lung weights. Macroscopic and microscopic severity scores (mean +/- SE) of HBO-treated animals with pancreatitis (8.3 +/- 0.7; 9.6 +/- 0.4) were lower than those of controls (10.5 +/- 0.5; 11.1 +/- 0.4) (p = 0.02 and p = 0.03, respectively). The HBO-treated group had reduced pancreatic necrosis compared to controls (40 +/- 4% vs. 54 +/- 4%; p = 0.003). There was no difference in pulmonary edema between the groups. Median survival in the HBO-treatment group was 51 h, compared to 26 h in controls. Day-7 survival was significantly improved in the HBO-treated animals compared to controls (40% vs. 27%; p = 0.04). HBO therapy reduces overall severity, decreases the extent of necrosis, and improves survival in severe acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

Nikfarjam

Cuthbertson

Malcontenti‐Wilson

et al. 2007

Journal of Gastrointestinal Surgery

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“…In 1775 Joseph Priestley reported the injurious character of dephlogisticated air, or oxygen as it is nowadays called: "Though pure dephlogisticated air might be very useful as a medicine, it might not be proper for us in the usual healthy state to the body" (Bean, 1945;Winter and Smith, 1972;Wolfe and DeVries, 1975). However, it took over 100 years before this statement was confirmed beyond doubt.…”

Section: A Bit Of Historymentioning

confidence: 99%

Assessment of pulmonary oxygen toxicity: Relevance to professional diving; a review

Ooij

Hollmann

Hulst

et al. 2013

Respiratory Physiology & Neurobiology

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“…groups were more susceptible to inhibition by OHP than other enz\Tnes (Mann and Quastel. 1945; Dickens, 1945; liaugaard, 1946;Bean, 1945). This was considered to be due to the oxidation of -SH groups by oxygen under pressure, and Haugaard (1946) found that redueed glutathione or cysteine could reverse OHP inactivation of at least one sulphydr>'l enzyme, succinie dehydrogenase.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Damage Due to High Pressure Oxygen Breathing in Rats

Jamieson

Ladner

1963

Aust J Exp Biol Med

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SUMMARY.The sulphydryl and disulphide contents of rat lnnRs were measured before and after exposure of rats to oxygen at 5 atmospheres absolute (OHP). After 45 minutes at this pressure lung damage occunvd, and a decrease in -SH groups together with an increase in -SS-groups was found, such that the -SH/-SS-ratio in the lung tissue was halved. Injections of pentobarbital sodium, which protetrt against OHP lung damage, reduce autookidatioD of -SH content of lung homogenate exposed to air in vitro and also reduce -SH oxidation in lungs of OHP exposed rats. INTRODUCTION.Recently it was shown that dehydrogenase activity decreases in lungs of rats which have bt-en exposed to high pressures of oxygen (OHP) (Jamieson and van den Brcnk, I9e2a). It was suggested that this may be dne to oxidation of sulphydryl (-SH) groups in vivo. Experiments in vitro had shown that enzymes containing essential sulphydry! groups were more susceptible to inhibition by OHP than other enz\Tnes (Mann and Quastel. 1945; Dickens, 1945; liaugaard, 1946;Bean, 1945). This was considered to be due to the oxidation of -SH groups by oxygen under pressure, and Haugaard (1946) found that redueed glutathione or cysteine could reverse OHP inactivation of at least one sulphydr>'l enzyme, succinie dehydrogenase. In the present series of experiments we have measured tbe quantity of both sulphydryl and disulphide groups in lungs of rats before and after exposure of animals to OHP to determine directly whetlit-r -SH groups are indeed oxidised by OHP in vico.

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Effects of Oxygen at Increased Pressure

Cited by 250 publications

References 0 publications

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

Assessment of pulmonary oxygen toxicity: Relevance to professional diving; a review

Pulmonary Damage Due to High Pressure Oxygen Breathing in Rats

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