Effects of oxidative stress on hyperglycaemia-induced brain malformations in a diabetes mouse model

Jin, Yifeng; Wang, Guang; Han, Shasha; He, Meiyao; Cheng, Xin; Ma, Zheng-lai; Wu, Xia; Yang, Xuesong; Liu, Guosheng

doi:10.1016/j.yexcr.2016.08.002

Cited by 13 publications

(13 citation statements)

References 27 publications

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“…Hyperglycemia has been shown to negatively affect embryo development 32 . Here, through comparing the development of gastrula chick embryos exposed to 50 mM glucose (high glucose (HG)) and/or 3 or 6 μM Baicalin for 26, 39 and 48 h (Fig.…”

Section: Resultsmentioning

confidence: 99%

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

et al. 2018

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In this study, the effects of Baicalin on the hyperglycemia-induced cardiovascular malformation during embryo development were investigated. Using early chick embryos, an optimal concentration of Baicalin (6 μM) was identified which could prevent hyperglycemia-induced cardiovascular malformation of embryos. Hyperglycemia-enhanced cell apoptosis was reduced in embryos and HUVECs in the presence of Baicalin. Hyperglycemia-induced excessive ROS production was inhibited when Baicalin was administered. Analyses of SOD, GSH-Px, MQAE and GABAA suggested Baicalin plays an antioxidant role in chick embryos possibly through suppression of outwardly rectifying Cl(−) in the high-glucose microenvironment. In addition, hyperglycemia-enhanced autophagy fell in the presence of Baicalin, through affecting the ubiquitin of p62 and accelerating autophagy flux. Both Baicalin and Vitamin C could decrease apoptosis, but CQ did not, suggesting autophagy to be a protective function on the cell survival. In mice, Baicalin reduced the elevated blood glucose level caused by streptozotocin (STZ). Taken together, these data suggest that hyperglycemia-induced embryonic cardiovascular malformation can be attenuated by Baicalin administration through suppressing the excessive production of ROS and autophagy. Baicalin could be a potential candidate drug for women suffering from gestational diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

et al. 2018

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“…Circle plot displayed the gene associated with peaks that were upregulated or downregulated within each GO term (Supplemental Figure 8, B and C). For example, peaks associated with the genes in the BMP, FoxP1, and Wnt cardiac morphogenetic signaling pathways were identified, and they have been linked to increased risk of fetal neurologic and cardiac developmental defects in matDM-exposed embryos (61)(62)(63)(64)(65). HG stress resulted in dysregulation of chromatin accessibility of genes important for reorganizing actin cytoskeleton, cell polarity, and alignment during tissue morphogenesis (66,67).…”

Section: Discussionmentioning

confidence: 99%

Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease

et al. 2017

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“…In a diabetic mouse model that mimicking pregestational DM, abnormal morphogenesis, and histological structure of brain in mouse fetuses were identified. [ 37 ] Enhanced cell apoptosis and activated oxidative stress were detected in mouse fetal brains, where Nrf2 signaling played a crucial role. [ 37 ] The role of oxidative stress on pathogenesis of autism was further supported by idiopathic autism mouse model.…”

Section: Discussionmentioning

confidence: 99%

“…[ 37 ] Enhanced cell apoptosis and activated oxidative stress were detected in mouse fetal brains, where Nrf2 signaling played a crucial role. [ 37 ] The role of oxidative stress on pathogenesis of autism was further supported by idiopathic autism mouse model. [ 38 , 39 ] It was demonstrated that gestational exposure to chemical trigger of oxidative stress strengthened some of the autistic-like traits, including delayed motor maturation and increased vocalization rate.…”

Section: Discussionmentioning

confidence: 99%

Association of maternal diabetes with autism spectrum disorders in offspring

Wan¹,

Zhang

et al. 2018

Medicine

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Studies on the association of maternal diabetes with autism spectrum disorders (ASDs) in offspring provide inconsistent findings; therefore an updated and comprehensive literature review and meta-analysis is necessary to perform in order to evaluate the available evidences.After searching databases systematically, we established the inclusion criteria and selected the eligible studies. In both overall and stratified analyses, the estimated effects were synthesized dependent on the presence or absence of heterogeneity.Twelve articles involving 16 studies were included and synthesized, demonstrating a significant association of maternal diabetes with ASDs among children (relative risk [RR] = 1.48). However, high heterogeneity was observed (I2 = 56.3%) and publication bias was identified. In terms of the analyses on reliable evidences from case-control studies, heterogeneity and publication bias disappeared, and the risk of ASDs was increased by 62% among diabetic mothers compared with non-diabetic mothers.Maternal diabetes, especially gestational diabetes mellitus, is associated with ASDs in offspring based on a limited number of convincing case-control studies. More large-scale population-based prospective studies are still needed to draw firm conclusions.

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Effects of oxidative stress on hyperglycaemia-induced brain malformations in a diabetes mouse model

Cited by 13 publications

References 27 publications

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease

Association of maternal diabetes with autism spectrum disorders in offspring

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