Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures

Wamil, Artur W.; Schmutz, M.; Portet, C.; Feldmann, K. F.; McLean, Michael J.

doi:10.1016/0014-2999(94)90787-0

Cited by 65 publications

(31 citation statements)

References 11 publications

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“…2). The ED 50 were 396(194-598) mg/kg in MES test, 283(27-538) mg/kg in PIC test, 308(0-705) mg/kg in PTZ test and 263(0-561) mg/kg in STR test. In diazepam-induced sleep test, the extract of O. sanctum multiplied by a factor of 3 the sleeping time of the control group (from 29 ± 5 min to 102 ± 27 min at a dose of 1000 mg/kg) [F(5,24) = 104; p < 0.001] (Fig.…”

Section: Effects Of O Sanctummentioning

confidence: 95%

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Evaluation of the Sedative and Anticonvulsant Properties of Three Cameroonian Plants

Okomolo¹,

Mbafor²,

Bum³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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Millettia thonningii, Ocinum sanctum and Securitaca longepedunculaca are used in traditional medicine in Cameroon to treat epilepsy, insomnia and headaches. Animal models of epilepsy (maximal electroshock (MES), n-methyl-d-aspartate (NMDA), pentylenetetrazol (PTZ), isonicotinic hydrazide acid (INH), picrotoxine (PIC) and strychnine (STR)-induced convulsions or turning behavior were used to evaluate anticonvulsant activity while diazepam-induced sleep test was used to evaluate sedative activity of the plants. Four doses of extracts were used for each plant (100, 200, 500 and 1000 mg/kg). At a dose of 1000 mg/kg, Millettia thonningii protected 60 and 90% of mice against MES and PTZ-induced convulsions, respectively. At the same dose, Millettia thonningii also protected 80% of mice against NMDA-induced turning behavior. At a dose of 1000 mg/kg, Ocinum sanctum provided complete protection against MES, PIC and STR-induced convulsions and 83.3% of protection in PTZ test. Securitaca longepedunculata completely protected (100%) mice in PIC test at a dose of 200 mg/kg, in MES test at a dose of 500 mg/kg and in PTZ test at a dose of 1000 mg/kg. 66.7% of mice were protected against STRinduced convulsions. All the three plants showed also sedative properties for they increased significantly and in a dose dependent manner the total sleep time induced by diazepam. The total sleep time of the control groups was multiplied by a factor of 3 at least by each extract. The presence of sedative and anticonvulsant activity in the three plants could explain their use in traditional medicine in the treatment of epilepsy and insomnia in Cameroon.

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Section: Effects Of O Sanctummentioning

confidence: 95%

“…was used as positive control. Tonic convulsions of the hind extremities of mice were induced by passing an alternating electrical current (50 …”

Section: Maximal Electroshock (Mes) Testmentioning

confidence: 99%

Evaluation of the Sedative and Anticonvulsant Properties of Three Cameroonian Plants

Okomolo¹,

Mbafor²,

Bum³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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show abstract

“…).The number of animals protected from tonic hind limb extension seizure and the latency of onset were determined in each dose group. Percentage protection against mortality was also calculated (Wamil et al, 1994).…”

Section: Maximal Electroshock Induced Seizures (Mes)mentioning

confidence: 99%

Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum

Dhayabaran¹,

Florance²,

Krsihnadas³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The aim of the present study was to evaluate the anticonvulsant effects of alcoholic root extract of Cardiospermum halicacabum L., Sapindaceae (ARECH), on the various murine models of epilepsy. The root extract of the plant was administered p.o. to male swiss albino mice at doses of 30, 100 and 300 mg/kg before evaluation. The brain monoamine levels were determined after two days administration. ARECH at doses of 100 and 300 mg/kg signifi cantly delayed the onset of clonus and tonus in pentylenetetrazol, isoniazid and picrotoxin-induced convulsions. Tonic hind limb extension was also decreased at doses of 100 and 300 mg/kg as compared to vehicle control in maximal electroshock model. No signifi cant motor toxicity was observed even at a highest dose administered, i.e. 900 mg/kg. Brain monoamine analysis by HPLC revealed a signifi cant increase in GABAergic activity in C+ (in cerebellum) and C-(except cerebellum). These results suggested that ARECH possesses a signifi cant anticonvulsant activity with a low motor toxicity profi le. This activity may be attributed to an increase in GABAergic activity.

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“…Im Gegensatz zu CBZ beruht die Wirkung auf Kalziumkanäle nicht auf einer direkten Blockade, sondern auf einer Reduktion der spannungs-und gebrauchsabhängigen Aktivität der Aktionspotentiale [39]. Zusätzlich reduziert MHD die glutamaterge synaptische Übertragung und Kalziumkanäle vom N-Typ [11,34].…”

Section: Modified-release (Mr) Oxcarbazepine -Overview and Clinical Eunclassified

Verzögert freigesetztes Oxcarbazepin – Überblick und klinische Erfahrungen

Steinhoff

2009

Z. Epileptol.

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Effects of oxcarbazepine and 10-hydroxycarbamazepine on action potential firing and generalized seizures

Cited by 65 publications

References 11 publications

Evaluation of the Sedative and Anticonvulsant Properties of Three Cameroonian Plants

Evaluation of the Sedative and Anticonvulsant Properties of Three Cameroonian Plants

Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum

Verzögert freigesetztes Oxcarbazepin – Überblick und klinische Erfahrungen

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