Abstract:INTRODUCTION: To investigate the effects of low estrogen environment on cognitive function and estrogen receptors in APP/PS1 mice.
METHODS: A mouse model of cognitive dysfunction under low estrogen environment was established by removing ovaries, organelle morphology in CA1 area of mouse hippocampus was observed by transmission electron microscopy, Aβ deposition level in hippocampal area was detected by immunofluorescence and sulfur staining, serum estrogen level and oxidative stress index were detected by ELI… Show more
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