Effects of ovariectomy on antioxidant defence systems in the right ventricle of female rats with pulmonary arterial hypertension induced by monocrotaline

Siqueira, Rafaela; Colombo, Rafael; Conzatti, Adriana; Castro, Alexandre Luz de; Carraro, Cristina Campos; Tavares, Ângela Maria Vicente; Fernandes, Tania Regina Gattelli; Araújo, Alex Sander da Rosa; Belló‐Klein, Adriane

doi:10.1139/cjpp-2016-0445

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…Taguchi et al found that serum GGT could reflect the antioxidant properties in healthy Japanese men (29). Interestingly, a research from Siqueira et al showed that in female rats with PAH by ovariectomy, GGT could affect the oxidative stress and antioxidant system via estrogen (30). So, one of possible reasons was "estrogen withdrawal, " alleviating protective role of estrogen (E2) against oxidative damage (31).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension

Gui

Gong

et al. 2020

Front. Cardiovasc. Med.

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Background: The elevated gamma-glutamyltransferase (GGT) activity is regarded as an indicator of cardiovascular disease, with males having higher values than females. The greater incidence of idiopathic pulmonary arterial hypertension (IPAH) is observed in women, whereas prognosis is poor in men. The present study aims to investigate the potential association of GGT on male patients. Methods: Serum GGT levels were measured in 338 consecutive adult IPAH patients, who underwent bone morphogenetic protein receptor type 2 (BMPR2) genetic counseling, and matched with healthy subjects by sex and age. The followed interval was 48 ± 34 months. Results: Increased serum GGT levels were more common in patients with IPAH than controls (p < 0.001). GGT values were significantly higher in male patients than those of females (p < 0.001). Compared with female patients with BMPR2 mutation, GGT level in male patients with BMPR2 mutation was further increased (p = 0.002). Higher GGT levels were associated with worse hemodynamics and Nterminal pro B-type natriuretic peptide in all patients. However, males with a GGT concentration ≥ 53 U/L had a worse survival than those of females. Contrarily, if GGT concentration < 53 U/L, there was no survival difference between male and female patients. After adjustment for relevant variables of clinical features and hemodynamics, baseline higher GGT levels remained increased risks of all-cause mortality in males rather than females. During rehospitalization follow-up, male patients still had significantly higher values of GGT than females. Conclusions: Increased GGT levels were correlated with BMPR2 mutation, hemodynamic dysfunction, and poor outcomes in male patients with IPAH. Further studies are needed to explain the origin of abnormal GGT and its potential pathogenesis in men.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension

Gui

Gong

et al. 2020

Front. Cardiovasc. Med.

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“…In rats treated with monocrotaline to increase pulmonary artery pressure without inducing RV hypertrophy, RV hydrogen peroxide increases but SOD, catalase, and glutathione peroxidase activities are also enhanced (Siqueira et al, 2018).…”

Section: Ros Defense Systems In Rvmentioning

confidence: 99%

Review on Chamber-Specific Differences in Right and Left Heart Reactive Oxygen Species Handling

et al. 2018

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Reactive oxygen species (ROS) exert signaling character (redox signaling), or damaging character (oxidative stress) on cardiac tissue depending on their concentration and/or reactivity. The steady state of ROS concentration is determined by the interplay between its production (mitochondrial, cytosolic, and sarcolemmal enzymes) and ROS defense enzymes (mitochondria, cytosol). Recent studies suggest that ROS regulation is different in the left and right ventricle of the heart, specifically by a different activity of superoxide dismutase (SOD). Mitochondrial ROS defense seems to be lower in right ventricular tissue compared to left ventricular tissue. In this review we summarize the current evidence for heart chamber specific differences in ROS regulation that may play a major role in an observed inability of the right ventricle to compensate for cardiac stress such as pulmonary hypertension. Based on the current knowledge regimes to increase ROS defense in right ventricular tissue should be in the focus for the development of future therapies concerning right heart failure.

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Melatonin effects on oxidative stress and on TLR4/NF-kβ inflammatory pathway in the right ventricle of rats with pulmonary arterial hypertension

Lisboa,

Maciel de Souza,

Gaspar

et al. 2024

Molecular and Cellular Endocrinology

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Effects of ovariectomy on antioxidant defence systems in the right ventricle of female rats with pulmonary arterial hypertension induced by monocrotaline

Cited by 5 publications

References 55 publications

Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension

Prognostic Value of Gamma-Glutamyltransferase in Male Patients With Idiopathic Pulmonary Arterial Hypertension

Review on Chamber-Specific Differences in Right and Left Heart Reactive Oxygen Species Handling

Melatonin effects on oxidative stress and on TLR4/NF-kβ inflammatory pathway in the right ventricle of rats with pulmonary arterial hypertension

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